Zobrazeno 1 - 10
of 63
pro vyhledávání: '"V G Erwin"'
Publikováno v:
Alcoholism: Clinical and Experimental Research. 24:595-604
Background: Genetically based risk for development of alcoholism in humans seems to be related to initial sensitivity and/or acute tolerance to ethanol. The genetic basis for the development of tolerance has received less attention than other ethanol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b1104a7bd3ceeadcee5923ba03b70ce
https://doi.org/10.1111/j.1530-0277.2000.tb02030.x
https://doi.org/10.1111/j.1530-0277.2000.tb02030.x
Autor:
Vaughn M. Gehle, V G Erwin
Publikováno v:
Alcoholism: Clinical and Experimental Research. 24:579-587
Background: It has been proposed that development of tolerance to the behavioral effects of ethanol depends on the degree of impairment produced by the drug; that is, more sensitive individuals should develop greater tolerance. Tests of this hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76edfd831bb1b8e140fdec824fdbdba9
https://doi.org/10.1111/j.1530-0277.2000.tb02028.x
https://doi.org/10.1111/j.1530-0277.2000.tb02028.x
Publikováno v:
Alcoholism: Clinical and Experimental Research. 23:1262-1271
Background:C57BL/6 inbred mice prefer alcohol whereas DBA/2 mice avoid it. We describe the construction of congenic strains of mice in which DBA/2 alleles for alcohol avoidance were placed on a C57BL/6 background using phenotypic selection. Methods:M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7750a9dc8bdd99b78d67b17b4d4bf9a2
https://doi.org/10.1111/j.1530-0277.1999.tb04287.x
https://doi.org/10.1111/j.1530-0277.1999.tb04287.x
Autor:
V. G. Erwin, Paul D. Markel
Publikováno v:
Alcoholism: Clinical and Experimental Research. 23:605-610
A considerable investment in genetic mapping is necessary to confirm linkages of quantitative trait loci for complex traits such as ethanol sensitivity, a significant predictor of alcoholism. Before embarking on such intensive mapping efforts in larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b14ee12078f3dc3ccac9d7fcd2c90e9a
https://doi.org/10.1111/j.1530-0277.1999.tb04161.x
https://doi.org/10.1111/j.1530-0277.1999.tb04161.x
Publikováno v:
Alcoholism: Clinical and Experimental Research. 22:1673-1679
It has been speculated that tolerance to alcohol involves some form of neuronal plasticity that is similar to or the same as that mediating learning and memory. To investigate this possibility further, we tested the hypothesis that acute functional t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1652fe4e9ac3ec80f4c0d47e7de4a90
https://doi.org/10.1111/j.1530-0277.1998.tb03965.x
https://doi.org/10.1111/j.1530-0277.1998.tb03965.x
Publikováno v:
Behavior Genetics. 28:49-55
Various lines of evidence suggest that a polymorphism in the gene for proopiomelanocortin, Pomc1, might account for some portion of the genetic variance for open-field activity in the LS × SS RI strains. To test this hypothesis, approximately 1600 b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5dc32df041a7de628fdd321c10cff6a
https://doi.org/10.1023/a:1021408815540
https://doi.org/10.1023/a:1021408815540
Publikováno v:
Behavior Genetics. 28:39-47
The finding that stress-induced locomotor activity exhibited a significant strain × time interaction in the LS × SS RI strains prompted examination of QTL influencing this behavior as a function of time. The degree of genetic determination for loco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d72eb97d6d81f2e2c5b42172d4879cdc
https://doi.org/10.1023/a:1021456731470
https://doi.org/10.1023/a:1021456731470
Autor:
Thomas E. Johnson, V G Erwin, David W. Fulker, John C. DeFries, Paul D. Markel, Beth Bennett, Robin P. Corley
Publikováno v:
Behavior Genetics. 26:447-458
We are mapping the genes (quantitative trait loci or QTLs) that are responsible for individual differences in ethanol sensitivity, measured as the duration of loss of righting, reflex (LORR) and blood ethanol concentrations upon recovery of the right
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d5cbc96cf7f5446a8d0af291687543
https://doi.org/10.1007/bf02359489
https://doi.org/10.1007/bf02359489
Publikováno v:
Pharmacology Biochemistry and Behavior. 41:275-281
It is well known that chronic ethanol administration produces tolerance to the sedative-hypnotic and hypothermic effects as well as low-dose locomotor inhibitory effects of ethanol. We report herein characterization of a convenient method of producin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aacac4e21dd4601f6eb3ca1bb806bc69
https://doi.org/10.1016/0091-3057(92)90098-z
https://doi.org/10.1016/0091-3057(92)90098-z
Autor:
Tina Fay, Pequita Bludeau, Richard A. Deitrich, V G Erwin, Richard A. Radcliffe, Kirsten L. Floyd, Xin-Sheng Deng
Publikováno v:
Genes, brain, and behavior. 8(6)
The Alcohol Tolerant and Alcohol Non-Tolerant rats (AT, ANT) were selectively bred for ethanol-induced ataxia as measured on the inclined plane. Here we report on a quantitative trait locus (QTL) study in an F(2) intercross population derived from in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65b9fd9cec0c2fe50bd9d00264f0c28
https://pubmed.ncbi.nlm.nih.gov/19500156
https://pubmed.ncbi.nlm.nih.gov/19500156