Výsledky vyhledávání - "V G, Nicoletti"

Ubiquitin binds the amyloid b peptide and interferes with its clearance pathways

Autor: Giuseppe Grasso, Roberto Fattorusso, Luciano Pirone, Calcagno D, Francesco Bellia, Massimo Coletta, Sara García-Viñuales, Ahmed Imm, Emilia Pedone, Grazia R. Tundo, Danilo Milardi, Diego Sbardella, Claudio Iacobucci, Lanza, V. G. Nicoletti, Gaetano Malgieri, Gianluca D'Abrosca, Adriana Pietropaolo

Publikováno v: Chemical science (Online) Chem. Sci., 2019, 10, 2732 (2019). doi:10.1039/c8sc03394c
info:cnr-pdr/source/autori:F. Bellia, V. Lanza, S. Garcia-Vinuales, I. M. M. Ahmed, A. Pietropaolo, C. Iacobucci, G. Malgieri, G. D'Abrosca, R. Fattorusso, V. G. Nicoletti, D. Sbardella, G. R. Tundo, M. Coletta,L. Pirone,E. Pedone, D. Calcagno,G. Grasso and D. Milardi/titolo:Ubiquitin binds the amyloid b peptide and interferes with its clearance pathways/doi:10.1039%2Fc8sc03394c/rivista:Chemical science (Online)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:Chem. Sci., 2019, 10, 2732
Chemical Science

Appetite for ubiquitin: a gushy travel companion in the intracellular journey of the amyloid β peptide.
Several lines of evidence point to a compromised proteostasis associated with a reduction of the Ubiquitin Proteasome System (UPS) activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792f03f6255646de6b9b235d01b3180d

Zobrazit plný text záznamu

Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity

Autor: Ikhlas Mohamed Mohamud Ahmed, Grazia R. Tundo, Giosuè Costa, V. G. Nicoletti, Anna Santoro, Danilo Milardi, Gianluca D'Abrosca, Diego Sbardella, Alessandra Cannizzo, Francesco Bellia, Gaetano Malgieri, Adriana Pietropaolo, Sara García-Viñuales, Massimiliano Coletta, Stefano Alcaro, Roberto Fattorusso, Valeria Lanza, Mariaconcetta Arizzi, Giuseppe Grasso

Publikováno v: ChemMedChem
15 (2020): 302–316. doi:10.1002/cmdc.201900612
info:cnr-pdr/source/autori:Santoro A.M.; Lanza V.; Bellia F.; Sbardella D.; Tundo G.R.; Cannizzo A.; Grasso G.; Arizzi M.; Nicoletti V.G.; Alcaro S.; Costa G.; Pietropaolo A.; Malgieri G.; D'Abrosca G.; Fattorusso R.; Garcia-Vinuales S.; Ahmed I.M.M.; Coletta M.; Milardi D./titolo:Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from ?-Amyloid Toxicity/doi:10.1002%2Fcmdc.201900612/rivista:ChemMedChem (Print)/anno:2020/pagina_da:302/pagina_a:316/intervallo_pagine:302–316/volume:15

Proteasome malfunction parallels abnormal amyloid accumulation in Alzheimer's Disease (AD). Here we scrutinize a small library of pyrazolones by assaying their ability to enhance proteasome activity and protect neuronal cells from amyloid toxicity. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05aae170c72e9441febd8137a4cb1fa
http://hdl.handle.net/11591/424097

Zobrazit plný text záznamu

New Insight in Copper-Ion Binding to Human Islet Amyloid: The Contribution of Metal-Complex Speciation To Reveal the Polypeptide Toxicity

Autor: Enrico Rizzarelli, Antonio Magrì, V. G. Nicoletti, Diego La Mendola, Giuseppe Pappalardo

Publikováno v: Chemistry (Weinh., Print) 22 (2016): 13287–13300. doi:10.1002/chem.201602816
info:cnr-pdr/source/autori:Magri, Antonio; La Mendola, Diego; Nicoletti, Vincenzo Giuseppe; Pappalardo, Giuseppe; Rizzarelli, Enrico/titolo:New Insight in Copper-Ion Binding to Human Islet Amyloid: The Contribution of Metal-Complex Speciation To Reveal the Polypeptide Toxicity/doi:10.1002%2Fchem.201602816/rivista:Chemistry (Weinh., Print)/anno:2016/pagina_da:13287/pagina_a:13300/intervallo_pagine:13287–13300/volume:22

Type-2 diabetes (T2D) is considered to be a potential threat on a global level. Recently, T2D has been listed as a misfolding disease, such as Alzheimer's and Parkinson's diseases. Human islet amyloid polypeptide (hIAPP) is a molecule cosecreted in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9789b750ee7f1502c07e1362581fd1b
https://doi.org/10.1002/chem.201602816

Zobrazit plný text záznamu

Plný text ve formátu HTML

Cytotoxic phenanthroline derivatives alter metallostasis and redox homeostasis in neuroblastoma cells

Autor: Giuseppe Arena, Nicola Margiotta, Irina Naletova, Alessandra Curci, Giovanni Natile, Diego La Mendola, Cristina Satriano, V. G. Nicoletti, Enrico Rizzarelli

Publikováno v: Oncotarget

Copper homeostasis is generally investigated focusing on a single component of the metallostasis network. Here we address several of the factors controlling the metallostasis for neuroblastoma cells (SH-SY5Y) upon treatment with 2,9-dimethyl-1,10-phe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c23edd0db3e25b1e0ac04359af45671
http://hdl.handle.net/20.500.11769/360441

Zobrazit plný text záznamu

Receptor-mediated toxicity of human amylin fragment aggregated by short- and long-term incubations with copper ions

Autor: V. G. Nicoletti, Giuseppe Caruso, Susan M. Lunte, Donatella A. Distefano, Claudia G. Fresta, Giuseppe Lazzarino, Paolo Parlascino

Human amylin (hA1-37) is a polypeptide hormone secreted in conjunction with insulin from the pancreatic β-cells involved in the pathogenesis of type 2 diabetes mellitus (T2DM). The shorter fragment hA17-29 than full-length peptide is capable to form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f4d5881227d666fab2d1a03a6ceddf
http://hdl.handle.net/20.500.11769/43681

Zobrazit plný text záznamu

Trehalose effects on α-crystallin aggregates

Autor: V. G. Nicoletti, Bruno Pignataro, Claudia Cascio, Francesco Attanasio, Anna Savarino, Enrico Rizzarelli, Salvatore Fisichella

Publikováno v: Biochemical and biophysical research communications
354 (2007): 899–905. doi:10.1016/j.bbrc.2007.01.061
info:cnr-pdr/source/autori:Attanasio F., C. Cascio, S. Fisichella, V. G. Nicoletti, B. Pignataro, A. Savarino and E. Rizzarelli/titolo:Trehalose effects on alpha-crystallin aggregates/doi:10.1016%2Fj.bbrc.2007.01.061/rivista:Biochemical and biophysical research communications (Print)/anno:2007/pagina_da:899/pagina_a:905/intervallo_pagine:899–905/volume:354

alpha-Crystallin in its native state is a large, heterogeneous, low-molecular weight (LMW) aggregate that under certain conditions may progressively became part of insoluble high-molecular weight (HMW) systems. These systems are supposed to play a re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34d8bd2bf0dd7588ff638a05fb4c7b4
https://doi.org/10.1016/j.bbrc.2007.01.061

Zobrazit plný text záznamu

The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor

Autor: V. G. Nicoletti, Giuseppe Pandini, Enrico Rizzarelli, Cristina Satriano, Diego La Mendola, Fiorenza Gianì, Adriana Pietropaolo, Alessio Travaglia

Publikováno v: Frontiers in Neuroscience

The nerve growth factor (NGF) N-terminus peptide, NGF(1-14), and its acetylated form, Ac-NGF(1-14), were investigated to scrutinise the ability of this neurotrophin domain to mimic the whole protein. Theoretical calculations demonstrated that non-cov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec62c0c97aeb07d489057ca5d734dc5

Zobrazit plný text záznamu

Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties

Autor: Antonio Magrì, Irina Naletova, Alessandro Giuffrida, Giovanni Tabbì, Cristina Satriano, Giuseppe Pappalardo, Francesco Attanasio, V. G. Nicoletti

Publikováno v: Journal of inorganic biochemistry 164 (2016): 59–69. doi:10.1016/j.jinorgbio.2016.08.013
info:cnr-pdr/source/autori:Magri, Antonio; Tabbi, Giovanni; Giuffrida, Alessandro; Pappalardo, Giuseppe; Satriano, Cristina; Naletova, Irina; Nicoletti, Vincenzo G.; Attanasio, Francesco/titolo:Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties/doi:10.1016%2Fj.jinorgbio.2016.08.013/rivista:Journal of inorganic biochemistry/anno:2016/pagina_da:59/pagina_a:69/intervallo_pagine:59–69/volume:164

Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that encompasses the sequence 4-7 of N-terminal domain of the adrenocorticotropic hormone and a C-terminal Pro-Gly-Pro tripeptide. N-terminal amino group acetylation (Ac-Semax) modulates the chemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7688e3674956a8a6eedfc59dfad325
https://pubmed.ncbi.nlm.nih.gov/27586814

Zobrazit plný text záznamu

Copper, differently from zinc, affects the conformation, oligomerization state and activity of bradykinin

Autor: Giuseppe Grasso, Danilo Milardi, V. G. Nicoletti, Adriana Pietropaolo, Irina Naletova

Publikováno v: Metallomics (Online) 8 (2016): 750–761. doi:10.1039/c6mt00067c
info:cnr-pdr/source/autori:Naletova, Irina; Nicoletti, Vincenzo G; Milardi, Danilo; Pietropaolo, Adriana; Grasso, Giuseppe/titolo:Copper, differently from zinc, affects the conformation, oligomerization state and activity of bradykinin./doi:10.1039%2Fc6mt00067c/rivista:Metallomics (Online)/anno:2016/pagina_da:750/pagina_a:761/intervallo_pagine:750–761/volume:8

The sole role of bradykinin (BK) as an inflammatory mediator is controversial, as recent data also support an anti-inflammatory role for BK in Alzheimer's disease (AD). The involvement of two different receptors (B1R and B2R) could be a key to unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbf81240893d5dc6731072203044bf2
http://hdl.handle.net/20.500.11769/19002

Zobrazit plný text záznamu

The neglected role of copper ions in wound healing

Autor: V. G. Nicoletti, Alessio Travaglia, Allison Paige Kornblatt

Wound healing is a complex biological process that aims to repair damaged tissue. Even though many biological and biochemical mechanisms associated with the steps of physiological wound healing are known, there is still significant morbidity and mort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d19457c90ca2f7621c047e978869a6b
http://hdl.handle.net/20.500.11769/19003

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání