Recurrent disease detection after resection of pancreatic ductal adenocarcinoma using a recurrence-focused surveillance strategy (RADAR-PANC): protocol of an international randomized controlled trial according to the Trials within Cohorts design

Autor: L. A. Daamen, I. W. J. M. van Goor, V. P. Groot, P. C. M. Andel, L. A. A. Brosens, O. R. Busch, G. A. Cirkel, N. Haj Mohammad, H. D. Heerkens, I. H. J. T. de Hingh, F. Hoogwater, H. W. M. van Laarhoven, M. Los, G. J. Meijer, V. E. de Meijer, R. Pande, K. J. Roberts, J. Stoker, M. W. J. Stommel, G. van Tienhoven, R. C. Verdonk, H. M. Verkooijen, F. J. Wessels, J. W. Wilmink, M. G. Besselink, H. C. van Santvoort, M. P. W. Intven, I. Q. Molenaar, for the Dutch Pancreatic Cancer Group

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-18 (2024)

Abstract Background Disease recurrence remains one of the biggest concerns in patients after resection of pancreatic ductal adenocarcinoma (PDAC). Despite (neo)adjuvant systemic therapy, most patients experience local and/or distant PDAC recurrence w

Externí odkaz: https://doaj.org/article/ba5d1663657942199349b99fc6296573

Radiofrequency ablation and chemotherapy versus chemotherapy alone for locally advanced pancreatic cancer (PELICAN): study protocol for a randomized controlled trial

Autor: M. S. Walma, S. J. Rombouts, L. J. H. Brada, I. H. Borel Rinkes, K. Bosscha, R. C. Bruijnen, O. R. Busch, G. J. Creemers, F. Daams, R. M. van Dam, O. M. van Delden, S. Festen, P. Ghorbani, D. J. de Groot, J. W. B. de Groot, N. Haj Mohammad, R. van Hillegersberg, I. H. de Hingh, M. D’Hondt, E. D. Kerver, M. S. van Leeuwen, M. S. Liem, K. P. van Lienden, M. Los, V. E. de Meijer, M. R. Meijerink, L. J. Mekenkamp, C. Y. Nio, I. Oulad Abdennabi, E. Pando, G. A. Patijn, M. B. Polée, J. F. Pruijt, G. Roeyen, J. A. Ropela, M. W. J. Stommel, J. de Vos-Geelen, J. J. de Vries, E. M. van der Waal, F. J. Wessels, J. W. Wilmink, H. C. van Santvoort, M. G. Besselink, I. Q. Molenaar, for the Dutch Pancreatic Cancer Group

Publikováno v: Trials, Vol 22, Iss 1, Pp 1-12 (2021)

Abstract Background Approximately 80% of patients with locally advanced pancreatic cancer (LAPC) are treated with chemotherapy, of whom approximately 10% undergo a resection. Cohort studies investigating local tumor ablation with radiofrequency ablat

Externí odkaz: https://doaj.org/article/3d301f6bd2bd4bac89f7f45ee7d3f040

Effect of centralization and regionalization of pancreatic surgery on resection rates and survival

Autor: Tara M. Mackay, I.H.J.T. de Hingh, Martijn W J Stommel, Pauline A. J. Vissers, Anouk E J Latenstein, V. E. de Meijer, L.G.M. van der Geest, Marc G. Besselink, C.H.J. van Eijck

Publikováno v: British Journal of Surgery, 108, 826-833
The British journal of surgery, 108(7), 826-833. John Wiley & Sons Ltd.
British Journal of Surgery, 108(7), 826-833. Wiley
British Journal of Surgery, 108, 7, pp. 826-833

Background Centralization of pancreatic surgery in the Netherlands has been ongoing since 2011. The aim of this study was to assess how centralization has affected the likelihood of resection and survival of patients with non-metastatic pancreatic he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d8e81ff8b1bed4e02a2546dae84a73
https://doi.org/10.1093/bjs/znaa146

Extending the viability of human precision-cut intestinal slice model for drug metabolism studies

Autor: C, Biel, O, Martinec, B, Sibering, K, van Summeren, A M A, Wessels, D J, Touw, K P, de Jong, V E, de Meijer, K N, Faber, J P Ten, Klooster, I A M, de Graaf, P, Olinga

Publikováno v: Archives of toxicology. 96(6)

Human Precision-cut intestinal slices (hPCIS) are used to study intestinal physiology, pathophysiology, drug efficacy, toxicology, kinetics, and metabolism. However, the use of this ex vivo model is restricted to approximately a 24 h timeframe becaus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9bca54d85e7c59bb3fe14b7a550394d9
https://pubmed.ncbi.nlm.nih.gov/35428896

The treatment and survival of elderly patients with locally advanced pancreatic cancer:A post-hoc analysis of a multicenter registry

Autor: R.M. van Dam, I. H. J. T. de Hingh, V. E. de Meijer, Leonie J. M. Mekenkamp, Johanna W. Wilmink, Derk Jan A. de Groot, Martijn R. Meijerink, N. Haj Mohammad, J.F.M. Pruijt, Koop Bosscha, Gijs A. Patijn, M. Los, Lilly J H Brada, H.C. van Santvoort, G.J.M. Creemers, Marco B. Polee, Sebastiaan Festen, Geert A. Cirkel, J. de Vos-Geelen, Emile D. Kerver, I.Q. Molenaar, M.G. Besselink, M. Liem, J. A. Ropela, M.S. Walma, J.W.B. de Groot, Martijn W J Stommel

Publikováno v: for the Dutch Pancreatic Cancer Group 2021, ' The treatment and survival of elderly patients with locally advanced pancreatic cancer : A post-hoc analysis of a multicenter registry ', Pancreatology, vol. 21, no. 1, pp. 163-169 . https://doi.org/10.1016/j.pan.2020.11.012
Pancreatology, 21, 163-169
Pancreatology, 21(1), 163-169. Elsevier
Pancreatology, 21, 1, pp. 163-169
Pancreatology, 21(1), 163-169. S. Karger AG
Pancreatology, 21(1), 163-169. ELSEVIER SCIENCE BV

Contains fulltext : 239089.pdf (Publisher’s version ) (Closed access) BACKGROUND: The treatment options for patients with locally advanced pancreatic cancer (LAPC) have improved in recent years and consequently survival has increased. It is unknown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5414ed7d7980dab4a07cdbd070c10f3d
https://research.vumc.nl/en/publications/01ec0bf4-0c27-4e80-99e6-7fc4c055e18f