Zobrazeno 1 - 10
of 175
pro vyhledávání: '"V E Eysselein"'
Publikováno v:
European Journal of Gastroenterology & Hepatology. 11:1305-1310
Objective/background Non-mitogenic biological activity such as modulation of mucosal blood flow is suspected to convey the protective effects of epidermal growth factor (EGF) in vivo. The aims of our present study were to determine the effects of EGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c993729ab74a649e3fddfc3d82a9757c
https://doi.org/10.1097/00042737-199911000-00021
https://doi.org/10.1097/00042737-199911000-00021
Autor:
F Procaccino, V.S. Buslon, E.P. Sandgren, H.V. Carey, J Lakshmanan, V E Eysselein, S. W. French, N.-N. Chai, M. W. Büchler, Bernhard Egger
Publikováno v:
Gut. 43:64-70
Background—Transforming growth factor α (TGF-α) knockout mice have increased susceptibility to dextran sodium sulphate (DSS) induced colitis.Aim—To substantiate the findings that TGF-α is a key mediator of colonic mucosal protection and/or rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67c4d2d95712168f108429e2d7c7661
https://doi.org/10.1136/gut.43.1.64
https://doi.org/10.1136/gut.43.1.64
Autor:
H. S. Ennes, W. J. Snape, P. Hoffmann, J. M. Zeeh, F. Procaccino, J. A. McRoberts, V. E. Eysselein
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 272:G481-G487
We recently demonstrated upregulation of insulin-like growth factor I (IGF-I) binding sites in the smooth muscle layer of inflamed rat colon. The increase in binding sites was due to increased expression of IGF binding proteins (IGFBPs), which modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b2e0e49f3b947a85ba5f380fd97c70
https://doi.org/10.1152/ajpgi.1997.272.3.g481
https://doi.org/10.1152/ajpgi.1997.272.3.g481
Publikováno v:
Inflammatory Bowel Diseases. 3:303-313
Extrinsic and intrinsic neurons of the gut contain multiple neuropeptides, which through complex interactions modulate mucosal defense, inflammation, and repair in response to injury. Initial changes of the neurovascular peptidergic system may repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfebed5eaa0c796043afe849d796c0d
https://doi.org/10.1097/00054725-199712000-00008
https://doi.org/10.1097/00054725-199712000-00008
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 259:G889-G897
Primary afferent nerve terminals located in the mammalian gut wall may play a role in region-specific modulation of gastrointestinal motility. In the present study, we sought to characterize the effect of neuropeptides released from these afferents b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691515cc754d1c5233be22f587a45b3f
https://doi.org/10.1152/ajpgi.1990.259.5.g889
https://doi.org/10.1152/ajpgi.1990.259.5.g889
Publikováno v:
Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress. 115
Inadequate healing and consequent leakage from large bowel anastomoses are a significant cause of morbidity and mortality following large bowel surgery. Systemic application of KGF has been shown to promote mucosal healing in models of colitis in rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6658f60bdb52d2bf12060ffd60711fc0
https://pubmed.ncbi.nlm.nih.gov/14518220
https://pubmed.ncbi.nlm.nih.gov/14518220
Publikováno v:
Digestive diseases and sciences. 44(4)
Keratinocyte growth factor (KGF) is emerging as an important mediator of mucosal defense and repair in the colon. The aim of the present study was to evaluate and further characterize the effects of exogenous KGF administration utilizing the dextran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2dbf33a151ca0c5f085f766e69477ee4
https://pubmed.ncbi.nlm.nih.gov/10219846
https://pubmed.ncbi.nlm.nih.gov/10219846
Autor:
M, Reinshagen, G, Flämig, S, Ernst, I, Geerling, H, Wong, J H, Walsh, V E, Eysselein, G, Adler
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 286(2)
Recently we demonstrated that sensory denervation with the neurotoxin capsaicin worsened the inflammation in an acute and chronic model of experimental colitis, which suggests a protective role of sensory nerve fibers during gut inflammation. Because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::968626adaa098458e771cff81c0450c9
https://pubmed.ncbi.nlm.nih.gov/9694917
https://pubmed.ncbi.nlm.nih.gov/9694917
Autor:
F. J. Ho, J. E. Shively, Joseph R. Reeve, S. R. Brazer, V. E. Eysselein, Peter Chew, Rodger A. Liddle, T. D. Lee, G. Rosenquist, M. T. Davis, U. Regner, J. Zeeh
Publikováno v:
The American journal of physiology. 270(5 Pt 1)
Many biologically active peptides exist in multiple molecular forms, but the functional significance of regions outside the region of bioactivity is unknown. The biological and immunological data presented in this study indicate that cholecystokinin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fbcbae511ab9c5e4912976630ed337
https://pubmed.ncbi.nlm.nih.gov/8967499
https://pubmed.ncbi.nlm.nih.gov/8967499
Publikováno v:
The American journal of gastroenterology. 88(6)
Substance P, a neurotransmitter found in colonic mucosa, can alter gut immunologic, vascular, and motor phenomena. Thus, it may have an important role in the pathogenesis of ulcerative colitis (UC) and Crohn's disease (CD). By radioimmunoassay of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5856dc3212506b96d2d1c5cb44c261f
https://pubmed.ncbi.nlm.nih.gov/7684884
https://pubmed.ncbi.nlm.nih.gov/7684884