Zobrazeno 1 - 10
of 137
pro vyhledávání: '"V E, Pastorova"'
Autor:
L. A. Lyapina, V. E. Pastorova, T. Yu. Obergan, M. E. Grigor’eva, T. A. Shubina, L. A. Andreeva, N. F. Myasoedov
Publikováno v:
Biology Bulletin. 39:60-64
Heparin was bound to the arginine-containing peptide Arg-Pro-Gly-Pro with the molar ratio of heparin to the peptide 1 : 1. The complex compound showed antiplatelet, anticoagulative, and fibrin-depolymerization activities. In an in vivo study, in type
Publikováno v:
Biology Bulletin. 38:165-175
Aanalysis of the literature and our own research on the physiological effects of complex compounds of heparin with low molecular ligands (amino acids, regulatory peptides) is presented. It is proved that anticoagulative effects in blood flow were con
Autor:
M. N. Mamontov, L. A. Lyapina, V. E. Pastorova, M. A. Feofanova, L. S. Nikolaeva, A. N. Semenov
Publikováno v:
Russian Journal of Inorganic Chemistry. 52:645-651
The acid-base and complexing properties of Logiparin (a low-molecular-weight variety (LMH) of heparin (H4L) with magnesium and calcium ions were studied using mathematical modeling of chemical equilibria in aqueous solutions of Logiparin and its solu
Publikováno v:
Biology Bulletin. 33:488-491
A significant and considerable decrease in abnormally high platelet aggregation has been demonstrated after intramuscular administration of sodium adenosine triphosphate (ATP) to rats with depressed anticoagulant system (in aging rats at the age of 1
Publikováno v:
Biology Bulletin. 33:153-161
Experimental and theoretical demonstrations of different effect of certain regulatory peptides (RPs) on blood coagulation are available. The problem of the role of RPs in hemostatic processes becomes particularly significant since, first, the peptide
Publikováno v:
Biology Bulletin. 32:179-182
Biochemical methods confirmed the presence of the heparin-ATP complex. Acidic sulfur and carboxyl groups proved to mediate heparin-ATP complex formation. The technique for preparation of the heparin complex at a 1:20 weight ratio of the components an
Publikováno v:
Pharmaceutical Chemistry Journal. 39:57-63
A new method for the computer simulation of chemical equilibria in multicomponent biological liquids has been developed on the basis of a consistent analysis of the databank on equilibria in solutions, combined with the AUTOEQUIL program for the calc
Publikováno v:
Biology Bulletin. 31:480-483
We studied the effect of chronic intraperitoneal administration of heparin–lysine complex on the state of the hemostatic and insular systems in young and senescent animals (rats). This complex exerted a positive effect on physiological function of
Publikováno v:
Biology Bulletin. 31:281-284
Natural heparin complexes proved to activate the anticoagulation system. The obtained experimental data convincingly confirm that glutamic acid alone, and particularly in a complex with heparin, has a considerable preventive potential and efficiently
Publikováno v:
Biology Bulletin of the Russian Academy of Sciences. 30:492-495
We studied hemocoagulation properties of the amino acid glycine in vitro and after intravenous administration in animals (rats). Addition of 10(-3) and 10(-4) M glycine to the plasma increases the aggregability of thrombocytes in vitro, while all oth