Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α.

Autor: Ottria A; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Zimmermann M; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Paardekooper LM; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Carvalheiro T; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Vazirpanah N; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Silva-Cardoso S; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Affandi AJ; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Chouri E; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., V D Kroef M; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Tieland RG; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Bekker CPJ; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Wichers CGK; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Rossato M; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Mocholi-Gimeno E; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Tekstra J; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Ton E; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., van Laar JM; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Cossu M; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Beretta L; Referral Center for Systemic Autoimmune Diseases, University of Milan & Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy., Garcia Perez S; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Pandit A; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Bonte-Mineur F; Department of Rheumatology and Clinical Immunology, Maasstad Hospital, Rotterdam., Reedquist KA; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., van den Bogaart G; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands., Radstake TRDJ; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht., Marut W; Laboratory of Translational Immunology.; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht.

Publikováno v: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2022 May 30; Vol. 61 (6), pp. 2682-2693.