Výsledky vyhledávání - "V B, Saprunova"

SkQ1 slows development of age-dependent destructive processes in retina and vascular layer of eyes of wistar and OXYS rats

Autor: Lora E. Bakeeva, Nataliya G. Kolosova, M. A. Lelekova, V. B. Saprunova

Publikováno v: Biochemistry (Moscow). 77:648-658

We show the development of clearly pronounced age-related pathological changes in eye tissues of Wistar and OXYS rats. Photoreceptor cells were virtually absent in all OXYS rats in the age of 24 months. Massive accumulations of lipofuscin granules we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d4938ef634f6b28820f9c1f3fd8dce
https://doi.org/10.1134/s0006297912060120

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Lipofuscin granule dynamics during development of age-related macular degeneration

Autor: A. V. Alexeevsky, Lora E. Bakeeva, D. I. Pilipenko, Nataliya G. Kolosova, V. B. Saprunova, A. Zh. Fursova

Publikováno v: Biochemistry (Moscow). 75:130-138

The pigment epithelium cell structure and therapeutic effect of antioxidant SkQ1, selectively penetrating into mitochondria from eye drops, were studied upon development in OXYS rats of age-related retinopathy as a model of macular degeneration. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42eb0f7867acab4d6a76f46fd265f6fc
https://doi.org/10.1134/s0006297910020021

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Novel mechanism of elimination of malfunctioning mitochondria (mitoptosis): Formation of mitoptotic bodies and extrusion of mitochondrial material from the cell

Autor: Konstantin G. Lyamzaev, V. B. Saprunova, Olga K. Nepryakhina, Olga Yu. Pletjushkina, Vladimir P. Skulachev, Lora E. Bakeeva, Boris V. Chernyak

Publikováno v: Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1777:817-825

Energy catastrophe, when mitochondria hydrolyze glycolytic ATP instead of producing respiratory ATP, has been modeled. In highly glycolyzing HeLa cells, 30–50% of the population survived after inhibition of respiration and uncoupling of oxidative p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ddc640b4473174c448871570347f0e3
https://doi.org/10.1016/j.bbabio.2008.03.027

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Cytochrome c oxidase activity in mitochondria of cardiomyocytes from isolated cardiac tissue incubated under long-term hypoxic conditions

Autor: Lora E. Bakeeva, I. M. Solodovnikova, V. B. Saprunova

Publikováno v: Cell and Tissue Biology. 2:153-157

Electron microscopic histochemistry based upon the oxidative polymerization of 3,3′-diaminobenzidine (DAB) was applied to identify cytochrome c oxidase activity. We found that the incubation of isolated small pieces of cardiac tissue over 72 h unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::560a6948df0c77d2af93a1a364945bfb
https://doi.org/10.1134/s1990519x08020089

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[Untitled]

Autor: V. B. Saprunova, Anton A. Tonshin, I. M. Solodovnikova, Lora E. Bakeeva, Lev S. Yaguzhinsky

Publikováno v: Biochemistry (Moscow). 68:875-881

Apoptosis in myocardial tissue slices was induced by extended incubation under anoxic conditions. Mitochondria were isolated from the studied tissue. A new method of isolation of mitochondria in special conditions by differential centrifugation at 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2ce53887b391b7798ba9686115cfff3
https://doi.org/10.1023/a:1025798931614

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Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis

Autor: Fetisova Ek, Liora E. Bakeeva, D. S. Izyumov, Mikhail Yu. Vyssokikh, Vladimir P. Skulachev, V. B. Saprunova, Boris V. Chernyak, Liarisa A. Shchepina, A. V. Avetisyan, Olga Yu. Pletjushkina

Publikováno v: Oncogene. 21:8149-8157

The release of cytochrome c from the intermembrane space of mitochondria into the cytosol is one of the critical events in apoptotic cell death. In the present study, it is shown that release of cytochrome c and apoptosis induced by tumor necrosis fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd42eb8fd656ef4b278b51a4e443804
https://doi.org/10.1038/sj.onc.1206053

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[Untitled]

Autor: V. B. Saprunova, Lora E. Bakeeva, L. S. Yagujinsky, S. A. Kazimirchuk, A. A. Tonshin

Publikováno v: Biochemistry (Moscow). 67:246-253

The effect of anoxic incubation of small slices of isolated rat hearts on respiration, internucleosomal DNA fragmentation, and mitochondrial ultrastructure was investigated. Anoxic incubation for 72 h induced apoptosis accompanied by internucleosomal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd66e43c3a5542128027d53136f1c094
https://doi.org/10.1023/a:1014426400741

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