Zobrazeno 1 - 10
of 35
pro vyhledávání: '"V B, Fiedler"'
Publikováno v:
The Journal of laboratory and clinical medicine. 120(4)
In a rhesus monkey endotoxin sepsis model established by intravenous administration of 300 mg/kg D-galactosamine and 0.1 microgram/kg lipopolysaccharide from Salmonella abortus equi, hemodynamic, respiratory, metabolic and hematologic variables; leve
Publikováno v:
Pharmacotherapy. 11(1)
The effects of a novel thromboxane antagonist, (3R)-3-(4-fluorophenylsulfonmido)-1,2,3,4-tetrahydro-9-carbazol epropanoic acid (BAY-U3405), on myocardial damage due to ischemia and reperfusion (added to accelerate the initiated injury) were studied i
Publikováno v:
Advances in prostaglandin, thromboxane, and leukotriene research.
The model of AA-induced sudden death employed in these investigations seems to be appropriate for studying the efficacy of TXA2-antagonists. The actions of TXA2 on platelets, respiratory and vascular tissue are considered as key events resulting in t
Publikováno v:
Stroke. 21
Bay U 3405 [(3R)-3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9- carbazolepropanoic acid] potently inhibits platelet aggregation, thromboxane A2-induced contraction of smooth muscles, and coronary artery thrombosis. We have previously demonstrate
Autor:
E, Perzborn, V B, Fiedler, F, Seuter, J P, Stasch, H, Weber, E, Sander, H, Böshagen, U, Rosentreter
Publikováno v:
Stroke. 21
The thromboxane A2-receptor antagonistic properties of Bay U 3405 [(3R)-3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9-carbaz o-lepropanoic acid] have been evaluated in various pharmacologic models. Bay U 3405 specifically inhibits platelet aggre
Publikováno v:
Stroke. 21
Bay U 3405 is a novel thromboxane receptor blocker. The present investigations describe its effects on experimental canine and porcine cardiac damage. In anesthetized dogs, a coronary artery was occluded for 6 hours and reperfused for 30 minutes. Bay
Publikováno v:
Journal of Pharmacological Methods. 3:201-219
A new ultrasonic measuring system (UM 3) is described. In addition, the construction of simple piezoelectric transducers is outlined. These can be implanted either in the epicardium or in the endocardium of the left ventricle in anesthetized or consc
Publikováno v:
European Heart Journal. 5:253-260
We examined in pentobarbital-anaesthetized dogs, the effects of intracoronary leukotriene D4 (LTD4) on large vessel (circumflex artery) flow and diameter and on calculations of late diastolic and total coronary resistance. Heart rate, systolic and en
Protective actions of carbocromene against amitriptyline-induced cardiotoxicity in anesthetized rats
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 279(1)
This study was designed to analyze the effects of carbocromene on circulatory and electrophysiologic failure in rats anesthetized with urethane. Amitriptyline was infused at 0.4 mg/kg/min (n = 12) until death of the animals at 30 +/- 6.7 min due to v
Autor:
V. B. Fiedler
Publikováno v:
Basic research in cardiology. 79(1)
The thrombolytic and hemodynamic properties of intracoronary streptokinase (SK) application were studied in an in-vivo canine model with left circumflex coronary artery thrombosis, initiated by electrical stimulation (150 microA, DC for 6 h) of the a