Výsledky vyhledávání - "V A Boussiotis"

Phase II Trial of Parathyroid Hormone after Double Umbilical Cord Blood Transplantation

Publikováno v: Biology of Blood and Marrow Transplantation. 18(12):1851-1858

Transplantation of one or two umbilical cord blood products is a useful alternative stem cell source. However, the limited number of stem cells in the infusion results in slow engraftment. In mouse models, administration of parathyroid hormone is an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575893dcc36b3f1512d0a6e2dc2b83db

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Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death

Autor: V A Boussiotis, B J Lee, G J Freeman, J G Gribben, L M Nadler

Publikováno v: The Journal of Immunology. 159:3156-3167

Since TCR-mediated stimulation induces T cells to become sensitive to Fas-mediated activation-induced cell death (Fas-AICD), we examined whether anergized and CD28-costimulated T cell clones were equally sensitive to Fas-AICD. Here, we show that TCR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54ec4770e293ad9b4f39be856d3c466a
https://doi.org/10.4049/jimmunol.159.7.3156

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Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

Autor: Gordon J. Freeman, John G. Gribben, Eva C. Guinan, Lee M. Nadler, V. A. Boussiotis

Publikováno v: Blood. 84:3261-3282

The above story illustrates the translation of basic scientific discoveries to the clinic. In vitro and preclinical in vivo experimentation suggests that modulation of the B7:CD28 pathway will result in either amplification or suppression of the immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f71ceb7adda3942f01dbfabb9625c23c
https://doi.org/10.1182/blood.v84.10.3261.bloodjournal84103261

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Prognostic factors in advanced stage Hodgkin's lymphoma: the significance of the number of involved anatomic sites

Autor: T P, Vassilakopoulos, M K, Angelopoulou, M P, Siakantaris, F N, Kontopidou, M N, Dimopoulou, A, Barbounis, V, Grigorakis, C, Karkantaris, K, Anargyrou, M, Chatziioannou, J, Rombos, V A, Boussiotis, G, Vaiopoulos, C, Kittas, G A, Pangalis

Publikováno v: European journal of haematology. 67(5-6)

Advanced Hodgkin's lymphoma (HL) is curable by conventional chemotherapy in 60--70% of patients. The pretreatment identification of a sizeable subgroup of patients with sufficiently low failure-free survival (FFS) to be eligible for investigational t

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https://pubmed.ncbi.nlm.nih.gov/11872075

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Bone marrow transplantation for low-grade lymphoma and chronic lymphocytic leukemia

Autor: V A, Boussiotis, A S, Freedman, L M, Nadler

Publikováno v: Seminars in hematology. 36(2)

Treatment of low-grade lymphoma and chronic lymphocytic leukemia (CLL) is a challenge for hematologists. The long physical history and the indolent nature of these diseases do not support the choice of aggressive treatment. However, regardless of the

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https://pubmed.ncbi.nlm.nih.gov/10319389

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The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor

Autor: G J, Freeman, A A, Cardoso, V A, Boussiotis, A, Anumanthan, R W, Groves, T S, Kupper, E A, Clark, L M, Nadler

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(6)

The identification of all CD28/CTLA-4 counterreceptors is critical to our understanding of this pivotal pathway of T cell activation. Clouding our understanding has been the reported discrepancies in expression and function of the B7-1 (CD80) molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fca13464e8a2cc68a619facb03485b31
https://pubmed.ncbi.nlm.nih.gov/9743327

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Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death

Autor: V A, Boussiotis, B J, Lee, G J, Freeman, J G, Gribben, L M, Nadler

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf3c171b4cdeb5cf91aa01160c8b2f44
https://pubmed.ncbi.nlm.nih.gov/9317113

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Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host disease and extend the donor pool

Autor: J G, Gribben, E C, Guinan, V A, Boussiotis, X Y, Ke, L, Linsley, C, Sieff, G S, Gray, G J, Freeman, L M, Nadler

Publikováno v: Blood. 87(11)

Graft-versus-host disease (GVHD) is initiated by adoptively transferred donor T cells that recognize host alloantigens. Whereas the absence of donor T-cell proliferation to host alloantigens in a mixed-leukocyte reaction does not predict freedom from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::295e1b9dd2fef462da3c4f4f7c254acb
https://pubmed.ncbi.nlm.nih.gov/8639863

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