Zobrazeno 1 - 10
of 25
pro vyhledávání: '"V A, Toporova"'
Autor:
V. A. Toporova, V. V. Argentova, T. K. Aliev, A. A. Panina, D. A. Dolgikh, M. P. Kirpichnikov
Publikováno v:
Journal of Genetic Engineering and Biotechnology, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background The biopharmaceutical industry is significantly growing worldwide, and the Chinese hamster ovary (CHO) cells are used as a main expression host for the production of recombinant monoclonal antibodies. Various metabolic engineering
Externí odkaz:
https://doaj.org/article/5e688550cea44f9d97a87acd76137fe4
Autor:
S. V. Korobova, G. V. Kornilaeva, V. A. Toporova, I. A. Nikolaeva, L. P. Trubcheninova, N. F. Trefilyeva, L. P. Sizyakina, I. G. Sidorovich, P. G. Aparin, R. M. Khaitov
Publikováno v:
Медицинская иммунология, Vol 18, Iss 1, Pp 51-62 (2016)
The development of HIV vaccine remains an important goal in prophylaxis and therapy of HIV/ AIDS epidemics. There are various approaches for development of а candidate vaccine based on induction of neutralizing antibodies and cell-mediated immunity.
Externí odkaz:
https://doaj.org/article/1dad465a38384ed38d959bfb023cd5fb
Autor:
D. S. Balabashin, V. A. Toporova, P. G. Sveshnikov, T. K. Aliev, A. A. Panina, Mikhail P. Kirpichnikov, V. V. Argentova, O. N. Solopova, V. S. Rybchenko, D. A. Dolgikh, S. A. Yakimov
Publikováno v:
Russian Journal of Bioorganic Chemistry. 46:572-581
The development of new therapies for malignant tumors is an urgent task. Currently, the humanized antibody trastuzumab is considered the “gold standard” in the complex treatment of breast tumors with overexpression of HER2, human epidermal growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e28ceefcc0b9f462a2bfb183be475c5e
https://doi.org/10.1134/s1068162020040159
https://doi.org/10.1134/s1068162020040159
Autor:
I. G. Dement’yeva, P. G. Sveshnikov, L. P. Pozdnyakova, Dmitry A. Dolgikh, T. K. Aliev, M. N. Bokov, V. A. Toporova, V. V. Argentova, Yu. A. Votchitseva, Mikhail P. Kirpichnikov, S.D. Varfolomeyev
Publikováno v:
Acta Naturae. 10:30-36
We obtained recombinant variants of human antibody FI6 broadly specific to hemagglutinins of the influenza A virus. On the basis of a bi-promoter (CMV, hEF1-HTLV) vector, we developed genetic constructs for the expression of the heavy and light chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec9369941e6d5b8aa8880059cf38aa3b
https://doi.org/10.32607/20758251-2018-10-2-30-36
https://doi.org/10.32607/20758251-2018-10-2-30-36
Autor:
I. G. Dementieva, Kirpichnikov Mp, D. A. Dolgikh, V. A. Toporova, O. B. Shchemchukova, A. A. Panina, D. S. Balabashin, M. N. Bokov, P. G. Sveshnikov, L. P. Pozdnyakova, T. K. Aliev
Publikováno v:
Acta Naturae
Currently, there are no approved therapies for targeted prevention and treatment of Ebola hemorrhagic fever. In the present work, we describe the development of a eukaryotic expression system for the production of three full-length chimeric antibodie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd484bb7218c06648fba10aceff5dc74
https://doi.org/10.32607/20758251-2017-9-4-84-91
https://doi.org/10.32607/20758251-2017-9-4-84-91
Autor:
V. V. Argentova, T. K. Aliev, V. V. Zarubaev, S. A. Klotchenko, A. A. Shtro, M. V. Sergeeva, V. A. Toporova, D. A. Dolgikh, P. G. Sveshnikov, V. A. Vasin, M. P. Kirpichnikov
Publikováno v:
Molecular Biology. 51:804-812
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f6622f57de8f8476ca56aea31438dc
https://doi.org/10.1134/s0026893317060024
https://doi.org/10.1134/s0026893317060024
Autor:
A. A. Panina, P. G. Sveshnikov, I. G. Dement’yeva, V. A. Toporova, Mikhail P. Kirpichnikov, M. N. Bokov, D. A. Dolgikh, L. P. Pozdnyakova, T. K. Aliev, O. B. Shemchukova
Publikováno v:
Russian Journal of Bioorganic Chemistry. 43:409-420
Previously, we have determined the nucleotide and amino acid sequences of the variable domains of three mouse monoclonal antibodies specific to the individual epitopes of the Ebola virus glycoprotein: GPE118 (IgG), GPE325 (IgM) and GPE534 (IgG) [1].
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c344734756f30e44beae7c7e451c354
https://doi.org/10.1134/s1068162017040069
https://doi.org/10.1134/s1068162017040069
Autor:
V. A. Toporova, V. S. Rybchenko, V. V. Argentova, D. A. Dolgikh, T. K. Aliev, Mikhail P. Kirpichnikov
Publikováno v:
Moscow University Biological Sciences Bulletin. 72:63-68
Production and application of therapeutic monoclonal antibodies are second only to vaccines in the world pharmaceutical market. The most common therapeutic antibodies are monoclonal antibodies (mAbs) of the IgG isotype that are produced in eukaryotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b241d29345f3ba97ee86b95fd700a1a
https://doi.org/10.3103/s0096392517020018
https://doi.org/10.3103/s0096392517020018
Autor:
T. K. Aliev, P. G. Sveshnikov, M. V. Sergeeva, Mikhail P. Kirpichnikov, V. V. Argentova, V. A. Toporova, Dmitry A. Dolgikh, A. A. Shtro, V. A. Vasin, V. V. Zarubaev, S. A. Klotchenko
Publikováno v:
Молекулярная биология. :927-937
Seasonal and highly infectious strains of the influenza A and influenza B viruses cause millions of cases of severe complications in elderly people, children, and patients with immune diseases each year. Immunoglobulin A (IgA), which is an active com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81b92d2205ef7213e200b18507f4a651
https://doi.org/10.7868/s0026898417060052
https://doi.org/10.7868/s0026898417060052
Autor:
I. G. Dement’eva, V. A. Toporova, V. V. Argentova, Dmitry A. Dolgikh, M. N. Bokov, Mikhail P. Kirpichnikov, P. G. Sveshnikov, L. P. Pozdnyakova, T. K. Aliev
Publikováno v:
Doklady Biochemistry and Biophysics. 478:34-36
We obtained dimeric forms of IgA1- and IgA2m1-isotypes of FI6 antibody broadly specific to hemagglutinins of different subtypes of influenza A virus. It was shown that the dimers of IgA1 isotype are characterized by a higher antigen-binding activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a2cbb8186ef9d3546dc9eeda7832d1
https://doi.org/10.1134/s160767291801009x
https://doi.org/10.1134/s160767291801009x