High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile

Autor: Kathleen M. Wragg, Hyon-Xhi Tan, Anne B. Kristensen, Catriona V. Nguyen-Robertson, Anthony D. Kelleher, Matthew S. Parsons, Adam K. Wheatley, Stuart P. Berzins, Daniel G. Pellicci, Stephen J. Kent, Jennifer A. Juno

Publikováno v: Cell Reports, Vol 31, Iss 11, Pp 107773- (2020)

Summary: Vδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit substantial heterogeneity in humans. Here, we demonstrate that CD26 and CD94 define transcriptionally, phenotypically, and functionally distinct Vδ2+ T

Externí odkaz: https://doaj.org/article/d7b6ee55cfda4c1b9c137a57e55e6253

Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d

Autor: Catriona V. Nguyen-Robertson, Spencer J. Williams, D. Branch Moody, Shihan Li, Dale I. Godfrey, Sidonia B G Eckle, Dylan G.M. Smith, Tan-Yun Cheng, Tram Nguyen, Scott J. J. Reddiex, Christopher M. Harpur, Jamie Rossjohn, Elena Batleska, Tamara Thelemann, Adam P Uldrich, Ildiko Van Rhijn, Daniel G. Pellicci, Catarina F. Almeida

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 118(34), 1. National Academy of Sciences
Proc Natl Acad Sci U S A

Natural killer T (NKT) cells detect lipids presented by CD1d. Most studies focus on type I NKT cells that express semi-invariant αβ T cell receptors (TCR) and recognize α-galactosylceramides. However, CD1d also presents structurally distinct lipid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620121843dcda6f950fef0976d9dfa78
https://doi.org/10.1073/pnas.2104420118

CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules

Autor: K. H. Gourley, Daniel G. Pellicci, R. De Rose, Catriona V. Nguyen-Robertson, Nicholas A Gherardin, Shihan Li, Hamish E G McWilliam, Jose A Villadangos, Dale I. Godfrey, Adam P Uldrich, Shian Su, DB Moody, Rebecca Seneviratna, Matthew E. Ritchie, Samuel J. Redmond, Catarina F. Almeida

CD1c presents lipid-based antigens to CD1c-restricted T cells which are thought to be a major component of the human T cell pool. The study of CD1c-restricted T cells, however, is hampered by the presence of an abundantly expressed CD1c-binding partn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b9901e8625f43e0d2cd9802ee12b263
https://doi.org/10.1101/2021.03.10.434884

CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules

Autor: Matthew E. Ritchie, Samuel J. Redmond, Adam P Uldrich, Catriona V. Nguyen-Robertson, Katherine H. A. Gourley, Catarina F. Almeida, D. Branch Moody, Hamish E G McWilliam, Shihan Li, Dale I. Godfrey, Nicholas A Gherardin, Fiona Ross, Daniel G. Pellicci, Robert De Rose, Rebecca Seneviratna, Jose A Villadangos, Shian Su

Publikováno v: Sci Immunol

CD1c presents lipid-based antigens to CD1c-restricted T cells, which are thought to be a major component of the human T cell pool. However, the study of CD1c-restricted T cells is hampered by the presence of an abundantly expressed, non-T cell recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff5701ca4d0567f9aff14778b5ddf9e
https://pubmed.ncbi.nlm.nih.gov/34172588

High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile

Autor: Matthew S. Parsons, Anthony D. Kelleher, Kathleen M. Wragg, Stephen J. Kent, Hyon-Xhi Tan, Stuart P. Berzins, Daniel G. Pellicci, Adam K. Wheatley, Anne B. Kristensen, Jennifer A Juno, Catriona V. Nguyen-Robertson

Publikováno v: Cell Reports, Vol 31, Iss 11, Pp 107773-(2020)

Summary: Vδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit substantial heterogeneity in humans. Here, we demonstrate that CD26 and CD94 define transcriptionally, phenotypically, and functionally distinct Vδ2+ T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb3470e84bdd5c71fa807495186d079
http://www.sciencedirect.com/science/article/pii/S2211124720307531