Zobrazeno 1 - 10 of 13 pro vyhledávání: '"V A, Ploplis"'
1
Targeting Plasminogen Activator Inhibitor-1: Role in Cell Signaling and the Biology of Domain-Specific Knock-in Mice
Autor: V. A. Ploplis, R. D. Balsara, Z. Xu
Publikováno v: Current Drug Targets. 8:982-995
It is well documented that elevated levels of PAI-1 in plasma can decrease the fibrinolytic activity in blood with an associated increased risk of thrombus formation. A diverse range of molecules including bacterial lipopolysaccharide (LPS), the infl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6685c0e0b4fb30673160eb406e180dc
https://doi.org/10.2174/138945007781662382
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2
Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen
Autor: Peter Carmeliet, H.R. Lijnen, D. Collen, Lieve Moons, EF Plow, Ann Bouché, V. A. Ploplis
Publikováno v: Scopus-Elsevier
Homozygous plasminogen-deficient (Plg-/-) mice had a significantly reduced thrombolytic capacity toward intravenously injected 125I-fibrin labeled plasma clots prepared from Plg-/- murine plasma (9% +/- 3% lysis after 8 hours; (mean +/- SEM, n = 6),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615749620a1071c17c8b6c7677689dab
https://doi.org/10.1182/blood.v88.3.870.870
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3
Plasminogen and Streptokinase
Autor: F. J. Castellino, V. A. Ploplis
Publikováno v: Handbook of Experimental Pharmacology ISBN: 9783642630293
The primary structure of human plasminogen (HPg), diagrammed in Fig. 1, has been deduced from the nucleotide sequence of the cDNA (Forsgren et al. 1987) and genomic DNA (Petersen et al. 1990) that encode this protein, and has been directly determined
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::699ffeb06a9d08521f2814dcab71b4bb
https://doi.org/10.1007/978-3-642-56637-0_2
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4
Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1
Autor: L S, Gutierrez, A, Schulman, T, Brito-Robinson, F, Noria, V A, Ploplis, F J, Castellino
Publikováno v: Cancer research. 60(20)
In vivo tumor progression in mice with targeted deficiencies in urokinase-type plasminogen activator (UPA-/-) and its inhibitor, plasminogen activator inhibitor-1 (PAI-1-/-), was studied using a fibrosarcoma tumor model. Murine T241 fibrosarcoma cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec5bab72ea389320d8597be4015cc543
https://pubmed.ncbi.nlm.nih.gov/11059781
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5
A role of plasminogen in atherosclerosis and restenosis models in mice
Autor: E F, Plow, V A, Ploplis, S, Busuttil, P, Carmeliet, D, Collen
Publikováno v: Thrombosis and haemostasis. 82
In addition to its preeminent role in fibrinolysis, the plasminogen system is believed to play a key role in mediating cell migration. Leukocyte migration into the vessel wall is a key and early event in the development of the lesions of atherosclero
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::351c4d8f6a7ead9a154a9bcf1b2d1a92
https://pubmed.ncbi.nlm.nih.gov/10695477
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6
Ovulation in plasminogen-deficient mice
Autor: A, Ny, G, Leonardsson, A C, Hägglund, P, Hägglöf, V A, Ploplis, P, Carmeliet, T, Ny
Publikováno v: Endocrinology. 140(11)
Many different studies suggest that plasmin generated from plasminogen plays a crucial role in the degradation of the follicular wall at the time of ovulation. We have assessed the physiological relevance of plasmin on ovulation by studying plasminog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::707e2678062bc94aa02ad7ab4392eaee
https://pubmed.ncbi.nlm.nih.gov/10537128
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7
Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice
Autor: V A, Ploplis, E L, French, P, Carmeliet, D, Collen, E F, Plow
Publikováno v: Blood. 91(6)
It is widely held that the plasminogen (Plg) system plays a role in inflammation through plasmin-mediated directional cell migration. However, substantial evidence for its involvement in the inflammatory response has been obtained from indirect studi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aeb20f36c15b045abe43af3d58a778fa
https://pubmed.ncbi.nlm.nih.gov/9490683
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8
Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen
Autor: H R, Lijnen, P, Carmeliet, A, Bouché, L, Moons, V A, Ploplis, E F, Plow, D, Collen
Publikováno v: Blood. 88(3)
Homozygous plasminogen-deficient (Plg-/-) mice had a significantly reduced thrombolytic capacity toward intravenously injected 125I-fibrin labeled plasma clots prepared from Plg-/- murine plasma (9% +/- 3% lysis after 8 hours; (mean +/- SEM, n = 6),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0502cf3a5aecfd1a81a287876a1c7825
https://pubmed.ncbi.nlm.nih.gov/8704243
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10
Initiation of the extrinsic pathway of coagulation. Association of factor VIIa with a cell line expressing tissue factor
Autor: Thomas S. Edgington, V A Ploplis, Daryl S. Fair
Publikováno v: Journal of Biological Chemistry. 262:9503-9508
We have examined initial assembly of the extrinsic pathway of blood coagulation on cell surfaces with radiolabeled human factor VIIa and a human fetal lung cell line possessing abundant functional tissue factor activity. Binding of factor VIIa to the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bca3bafc66c160e7f7721992c68fcd7
https://doi.org/10.1016/s0021-9258(18)47961-6
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