Výsledky vyhledávání - "V A, Nesmeianov"

[Monoclonal antibodies to type A, B, E and F botulinum neurotoxins]

Autor: S G, Abbasova, N V, Ruddenko, A Iu, Gorokhovatskiĭ, M V, Kapralova, I D, Vinogradova, Iu V, Vertiev, V A, Nesmeianov, E V, Grishin

Publikováno v: Bioorganicheskaia khimiia. 37(3)

Mouse monoclonal antibodies against the most acutely toxic substances, botulinum neurotoxins (BoNTs) of types A, B, E, and F, was generated and characterized, that recognize their respective toxins in natural toxin complex. Based on these antibodies,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30f16ae0f42c6cb0d1f27f8216bf8f33
https://pubmed.ncbi.nlm.nih.gov/21899049

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[New acellular pertussis vaccine, containing glucosaminylmuramyldipeptide]

Autor: B F, Semenov, N S, Zakharova, M V, Britsina, N U, Mertsalova, M N, Ozeretskovskaia, T I, Valiakina, R L, Komaleva, T M, Andronova, V A, Nesmeianov

Publikováno v: Zhurnal mikrobiologii, epidemiologii i immunobiologii. (6)

As shown in this work, the synthetic immunomodulator glucosaminylmuramyldipeptide (GMDP) can be included into acellular pertussis vaccine (APV). The optimal doses of GMDP, ranging from 0.001 to 0.0001 microg, have been found. These doses enhance the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cfd54f118585c8bb8f98daa363cc6ace
https://pubmed.ncbi.nlm.nih.gov/15636136

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[Induction of the anti-meningitis immunity with synthetic peptides. III. Immunoactive synthetic fragments of NspA protein from Neisseria meningitidis]

Autor: D O, Koroev, M B, Oboznaia, M N, Zhmak, T D, Volkova, M A, Titova, O V, Kotel'nikova, O E, Lakhtina, O M, Vol'pina, V A, Nesmeianov, A P, Alliluev, V T, Ivanov

Publikováno v: Bioorganicheskaia khimiia. 28(4)

Four potentially immunoactive peptide fragments of the NspA protein from the outer membrane of the bacterium Neisseria meningitidis were synthesized in order to create a synthetic vaccine against the meningococcal infection by the serogroup B bacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::edd717141b2bbef519bebefa5802bb4b
https://pubmed.ncbi.nlm.nih.gov/12197384

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[The production of mini antibodies against human granulocyte colony-stimulating factor using murine scFv combinatorial library]

Autor: A G, Laman, A O, Shepeliakovskaia, A B, Ulitin, E V, Markova, T Iu, Mareeva, N S, Bystrov, F A, Brovko, V A, Nesmeianov

Publikováno v: Bioorganicheskaia khimiia. 28(2)

To develop a phage display of single-chain antibodies (scFv), fractions of total cell DNA and RNA were obtained from splenocytes of naive mice. The DNA fragments encoding variable regions of light and heavy immunoglobulin chains were amplified and is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f765f8e6e4b996c02e19b7ada5141bb4
https://pubmed.ncbi.nlm.nih.gov/11962234

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[Bacteriorhodopsin retains the conformation of Val69-Gly72 fragment during functioning]

Autor: V S, Pashkov, T Iu, Mareeva, T A, Balashova, A A, Vychalkovskiĭ, L V, Samokhvalova, L K, Baĭdakova, I L, Rodionov, V A, Nesmeianov

Publikováno v: Bioorganicheskaia khimiia. 28(2)

Effect of the monoclonal antibody (MAb) 5B6 produced to the solubilized preparation of bacteriorhodopsin on the protein photocycle was studied to examine conformational rearrangements on the surface of functioning bacteriorhodopsin molecule. Using th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7164764a3675a7d2f8ab7722b420f4dd
https://pubmed.ncbi.nlm.nih.gov/11962232

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[Endogenous Tumor necrosis factor alpha unmasks the binding sites for N-acetylglucosaminyl-(beta1-4)-N-acetylmuramyl-alanyl-D-isoglutamine on the surface of melanoma cells]

Autor: E E, Petrova, T I, Valiakina, S V, Khaĭdukov, V A, Nesmeianov

Publikováno v: Bioorganicheskaia khimiia. 27(4)

The surface of the melanoma BRO cells was shown to contain binding sites for N-acetylglucosaminyl-(beta 1-4)-N-acetylmuramyl-alanyl-D-isoglutamine (GMDP). Their number (1500 +/- 200 per cell) and affinity (Kd = 10 +/- +/- 1.2 nM) were determined. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f6b8c40a196e648339e86270d291f75
https://pubmed.ncbi.nlm.nih.gov/11558258

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[Induction of antimeningitis immunity by synthetic peptides. II. Immunoactive synthetic fragments of OpaB protein from Neisseria meningitidis]

Autor: D O, Koroev, O M, Vol'pina, M N, Zhmak, M A, Kupriianova, V A, Nesmeianov, A P, Alliluev, O V, Kotel'nikova, V T, Ivanov

Publikováno v: Bioorganicheskaia khimiia. 27(1)

Mice of various lines were immunized by 11 synthetic peptides that correspond to the sequences of fragments of the OpaB protein from the outer membrane of Neisseria meningitidis involving the known human T-helper epitopes and all the potential mouse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56a3c6e496967f222cb448a05bf25a3a
https://pubmed.ncbi.nlm.nih.gov/11255637

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[Spatial structure of a Fab-fragment of a monoclonal antibody to human interleukin-2 in two crystalline forms at a resolution of 2.2 and 2.9 angstroms]

Autor: A V, Fokin, P V, Afonin, I Iu, Mikhaĭlova, I N, Tsygannik, T Iu, Mareeva, V A, Nesmeianov, W, Pangborn, N, Lee, W, Duax, E, Siszak, V Z, Pletnev

Publikováno v: Bioorganicheskaia khimiia. 26(8)

The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 A resolutions. The spatial structure of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f373ebafd433440e52e5f96b51d1096
https://pubmed.ncbi.nlm.nih.gov/11040993

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