Výsledky vyhledávání - "V A, Mit'kevich"

[Heat-shock protein HSP70 reduces the secretion of TNFα by neuroblastoma cells and human monocytes induced with beta-amyloid peptides]

Autor: M M, Yurinskaya, V A, Mit'kevich, M B, Evgen'ev, A A, Makarov, M G, Vinokurov

Publikováno v: Molekuliarnaia biologiia. 50(6)

The progress of neurodegeneration in Alzheimer's disease is closely associated with inflammatory processes in the brain tissues induced by beta-amyloid peptides (Aβ). In this paper, we showed that Aβ(1-42) and isoAβ(1-42) in human neuroblastoma ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a1d9c25d7aba8d4c6d185ef384d1498b
https://pubmed.ncbi.nlm.nih.gov/28064323

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[The ability of cells to adjust to the low oxigen content associated with Na,K-ATPase glutationilation]

Autor: I Iu, Petrushanko, O V, Simonenko, K M, Burnysheva, E A, Klimanova, E A, Dergousova, V A, Mit'kevich, O D, Lopina, A A, Makarov

Publikováno v: Molekuliarnaia biologiia. 49(1)

Decreasing the amount of oxygen in the tissues under hypoxic and ischemic conditions, observed at a number of pathologic processes, inevitably leads to their damage. One of the main causes of cell damage and death is a violation of the systems mainta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0973429b281eb92908dfceb1cbf7e6c3
https://pubmed.ncbi.nlm.nih.gov/25916122

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[Cellular targets of antitumor ribonucleases]

Autor: V A, Mit'kevich, A A, Makarov, O N, Il'inskaia

Publikováno v: Molekuliarnaia biologiia. 48(2)

Some ribonucleases (RNases) produce selective toxic effect on the cancer cells. The mechanism of this antitumor activity remains largely unclear. The subject of this review is the RNases interaction with cellular components, resulting in the inductio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2a0c589e96a4ddf2b6635ca00ff7c8b
https://pubmed.ncbi.nlm.nih.gov/25850290

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[Heat-shock protein HSP70 protects neuroblastoma cells SK-N-SH from the neurotoxic effects hydrogen peroxide and the β-amyloid peptide]

Autor: M M, Yurinskaya, V A, Mit'kevich, E P, Barykin, D G, Garbuz, M B, Evgen'ev, A A, Makarov, M G, Vinokurov

Publikováno v: Molekuliarnaia biologiia. 49(6)

Neuronal cell death in Alzheimer's disease is associated with the development of oxidative stress caused by the reactive oxygen species (ROS), which can be generated as a result of the effect of beta-amyloid peptides. One of the sources of ROS is hyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f85223b8b60a451807d05ad2bc69423
https://pubmed.ncbi.nlm.nih.gov/26710786

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[Expression of FLT3-ITD oncogene confers mice progenitor B-cells BAF3 sensitivity to the ribonuclease binase cytotoxic action]

Autor: V A, Mit'kevich, N N, Orlova, I Iu, Petrushanko, O V, Simonenko, P V, Spirin, M M, Prokofeva, A S, Gornostaeva, C, Stocking, A A, Makarov, V S, Prasolov

Publikováno v: Molekuliarnaia biologiia. 47(2)

Acute myeloid leukemia is the most common acute leukemia affecting adults, and its incidence increases with age. Along with chromosomal translocations in leukemic cells mutations in the genes of receptor tyrosine kinases KIT and FLT3 were found with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4495056c7fad7cea5b4c931aed8a456c
https://pubmed.ncbi.nlm.nih.gov/23808162

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[The interaction of NS3 protein of hepatitis C virus with polymethylen derivatives of nucleic bases]

Autor: A V, Mukovnia, V V, Komissarov, A M, Kritsyn, V A, Mit'kevich, V L, Tunitskaia, S N, Kochetkov

Publikováno v: Molekuliarnaia biologiia. 44(6)

NS3 protein of hepatitis C virus plays the key role in the virus functioning. It possesses three enzymatic activities, namely protease activity, associated with N-terminal domain of the protein, and helicase/NTPase activities specific for C-terminal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a84e86b8629fb5b480eaf751a37e26e6
https://pubmed.ncbi.nlm.nih.gov/21290826

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[X-ray diffraction and biochemical studies of W34F mutant ribonuclease binase]

Autor: K M, Poliakov, D A, Goncharuk, A A, Trofimov, T N, Safonova, V A, Mit'kevich, E N, Tkach, A A, Makarov, A A, Shul'ga

Publikováno v: Molekuliarnaia biologiia. 44(5)

The structures of two crystal modifications of the W34F mutant ribonuclease from the bacterium Bacillus intermedius (binase) were solved and refined at 1.7 and 1.1 A resolution. The kinetic parameters of the hydrolysis of substrates of different leng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a38e02b69dd2bf16f9b1ea2be5e4df51
https://pubmed.ncbi.nlm.nih.gov/21090247

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[Binase possesses a selective cytotoxic action on kit-transformed precursors of myeloid cells]

Autor: I Iu, Petrushanko, P V, Zelenikhin, V A, Mit'kevich, A A, Kleĭmenova, V S, Prasolov, A A, Makarov, O N, Il'inskaia

Publikováno v: Biofizika. 52(5)

The effect of cationic microbial ribonuclease from Bacillus intermedius (binase) on normal precursors of myeloid cells of FDC-P1 mice and kit-transformed precursors expressing the receptor of the growth factor of stem cells has been studied by flow-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8840e982f1843aea669cfa0d28283604
https://pubmed.ncbi.nlm.nih.gov/17969922

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[Inhibitors of ribonucleases]

Autor: G I, Iakovlev, V A, Mit'kevich, A A, Makarov

Publikováno v: Molekuliarnaia biologiia. 40(6)

RNases are the most important enzymes of cellular metabolism. They influence gene expression, cell growth and differentiation, participate in cell protection against pathogens and induction of apoptosis. Since intracellular RNases exist mainly in com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb6a8f9d94b2ce8710410f4c19c13744
https://pubmed.ncbi.nlm.nih.gov/17209423

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