In silico exploration of antinociceptive activity of 1,4-benzodiazepines: Molecular docking on α1 A-adrenoceptor, and phosphodiesterase 4

Autor: A. S. Akisheva, V. B. Larionov, M. Y. Golovenko, O. A. Makarenko, I. P. Valivodz, I. Y. Borysiuk, Y. O. Molodan

Publikováno v: Regulatory Mechanisms in Biosystems, Vol 15, Iss 2, Pp 327-336 (2024)

Recently, scientists have established that several benzodiazepines were found to enhance the activation of a cAMP response element pathway by α1A-adrenergic receptors, but this effect was attributed to off-target inhibition of phosphodiesterases 4.

Externí odkaz: https://doaj.org/article/e3ac540fd3f349c09aa62b8701c85f60

Axial distribution of gas temperature and sound speed in a pipe with a swirled flame

Autor: A. O. Malahov, V. M. Larionov, N. V. Konstantinov

Publikováno v: Известия высших учебных заведений: Проблемы энергетики, Vol 24, Iss 6, Pp 63-71 (2023)

Earlier, an experimental and theoretical study of pulsating combustion in a pipe with a tangential supply of a mixture of propane-butane fuel with air was carried out. It was found that the results of calculating the frequencies of gas oscillations d

Externí odkaz: https://doaj.org/article/80b76796b5d44b66a1b08900c7a7ae0d

Multiband Optical Variability of the Blazar 3C 454.3 on Diverse Timescales

Autor: Karan Dogra, Alok C. Gupta, C. M. Raiteri, M. Villata, Paul J. Wiita, S. O. Kurtanidze, S. G. Jorstad, R. Bachev, G. Damljanovic, C. Lorey, S. S. Savchenko, O. Vince, M. Abdelkareem, F. J. Aceituno, J. A. Acosta-Pulido, I. Agudo, G. Andreuzzi, S. A. Ata, G. V. Baida, L. Barbieri, D. A. Blinov, G. Bonnoli, G. A. Borman, M. I. Carnerero, D. Carosati, V. Casanova, W. P. Chen, Lang Cui, E. G. Elhosseiny, D. Elsaesser, J. Escudero, M. Feige, K. Gazeas, L. E. Gennadievna, T. S. Grishina, Minfeng Gu, V. A. Hagen-Thorn, F. Hemrich, H. Y. Hsiao, M. Ismail, R. Z. Ivanidze, M. D. Jovanovic, T. M. Kamel, G. N. Kimeridze, E. N. Kopatskaya, D. Kuberek, O. M. Kurtanidze, A. Kurtenkov, V. M. Larionov, L. V. Larionova, M. Liao, H. C. Lin, K. Mannheim, A. Marchini, C. Marinelli, A. P. Marscher, D. Morcuende, D. A. Morozova, S. V. Nazarov, M. G. Nikolashvili, D. Reinhart, J. O. Santos, A. Scherbantin, E. Semkov, E. V. Shishkina, L. A. Sigua, A. K. Singh, A. Sota, R. Steineke, M. Stojanovic, A. Strigachev, A. Takey, Amira A. Tawfeek, I. S. Troitskiy, Y. V. Troitskaya, An-Li Tsai, A. A. Vasilyev, K. Vrontaki, Zhongli Zhang, A. V. Zhovtan, N. Zottmann, Wenwen Zuo

Publikováno v: The Astrophysical Journal Supplement Series, Vol 276, Iss 1, p 1 (2024)

Due to its peculiar and highly variable nature, the blazar 3C 454.3 has been extensively monitored by the WEBT team. Here, we present for the first time these long-term optical flux and color variability results using data acquired in B , V , R , and

Externí odkaz: https://doaj.org/article/5441b01ffa024cf2a3376121a94cb407

Multimessenger Characterization of Markarian 501 during Historically Low X-Ray and γ-Ray Activity

Autor: H. Abe, S. Abe, V. A. Acciari, I. Agudo, T. Aniello, S. Ansoldi, L. A. Antonelli, A. Arbet-Engels, C. Arcaro, M. Artero, K. Asano, D. Baack, A. Babić, A. Baquero, U. Barres de Almeida, J. A. Barrio, I. Batković, J. Baxter, J. Becerra González, W. Bednarek, E. Bernardini, M. Bernardos, A. Berti, J. Besenrieder, W. Bhattacharyya, C. Bigongiari, A. Biland, O. Blanch, G. Bonnoli, Ž. Bošnjak, I. Burelli, G. Busetto, R. Carosi, M. Carretero-Castrillo, A. J. Castro-Tirado, G. Ceribella, Y. Chai, A. Chilingarian, S. Cikota, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, G. D’Amico, V. D’Elia, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, A. Del Popolo, M. Delfino, J. Delgado, C. Delgado Mendez, D. Depaoli, F. Di Pierro, L. Di Venere, E. Do Souto Espiñeira, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, D. Elsaesser, G. Emery, J. Escudero, V. Fallah Ramazani, L. Fariña, A. Fattorini, L. Foffano, L. Font, C. Fruck, S. Fukami, Y. Fukazawa, R. J. García López, M. Garczarczyk, S. Gasparyan, M. Gaug, J. G. Giesbrecht Paiva, N. Giglietto, F. Giordano, P. Gliwny, N. Godinović, R. Grau, D. Green, J. G. Green, D. Hadasch, A. Hahn, T. Hassan, L. Heckmann, J. Herrera, D. Hrupec, M. Hütten, R. Imazawa, T. Inada, R. Iotov, K. Ishio, I. Jiménez Martínez, J. Jormanainen, D. Kerszberg, Y. Kobayashi, H. Kubo, J. Kushida, A. Lamastra, D. Lelas, F. Leone, E. Lindfors, L. Linhoff, S. Lombardi, F. Longo, R. López-Coto, M. López-Moya, A. López-Oramas, S. Loporchio, A. Lorini, E. Lyard, B. Machado de Oliveira Fraga, P. Majumdar, M. Makariev, G. Maneva, N. Mang, M. Manganaro, S. Mangano, K. Mannheim, M. Mariotti, M. Martínez, A. Mas-Aguilar, D. Mazin, S. Menchiari, S. Mender, S. Mićanović, D. Miceli, T. Miener, J. M. Miranda, R. Mirzoyan, E. Molina, H. A. Mondal, A. Moralejo, D. Morcuende, V. Moreno, T. Nakamori, C. Nanci, L. Nava, V. Neustroev, M. Nievas Rosillo, C. Nigro, K. Nilsson, K. Nishijima, T. Njoh Ekoume, K. Noda, S. Nozaki, Y. Ohtani, T. Oka, A. Okumura, J. Otero-Santos, S. Paiano, M. Palatiello, D. Paneque, R. Paoletti, J. M. Paredes, L. Pavletić, M. Persic, M. Pihet, G. Pirola, F. Podobnik, P. G. Prada Moroni, E. Prandini, G. Principe, C. Priyadarshi, W. Rhode, M. Ribó, J. Rico, C. Righi, A. Rugliancich, N. Sahakyan, T. Saito, S. Sakurai, K. Satalecka, F. G. Saturni, B. Schleicher, K. Schmidt, F. Schmuckermaier, J. L. Schubert, T. Schweizer, J. Sitarek, V. Sliusar, D. Sobczynska, A. Spolon, A. Stamerra, J. Strišković, D. Strom, M. Strzys, Y. Suda, T. Surić, H. Tajima, M. Takahashi, R. Takeishi, F. Tavecchio, P. Temnikov, K. Terauchi, T. Terzić, M. Teshima, L. Tosti, S. Truzzi, A. Tutone, S. Ubach, J. van Scherpenberg, M. Vazquez Acosta, S. Ventura, V. Verguilov, I. Viale, C. F. Vigorito, V. Vitale, I. Vovk, R. Walter, M. Will, C. Wunderlich, T. Yamamoto, D. Zarić, The MAGIC Collaboration, M. Cerruti, J. A. Acosta-Pulido, G. Apolonio, R. Bachev, M. Baloković, E. Benítez, I. Björklund, V. Bozhilov, L. F. Brown, A. Bugg, W. Carbonell, M. I. Carnerero, D. Carosati, C. Casadio, W. Chamani, W. P. Chen, R. A. Chigladze, G. Damljanovic, K. Epps, A. Erkenov, M. Feige, J. Finke, A. Fuentes, K. Gazeas, M. Giroletti, T. S. Grishina, A. C. Gupta, M. A. Gurwell,, E. Heidemann, D. Hiriart, W. J. Hou, T. Hovatta, S. Ibryamov, M. D. Joner, S. G. Jorstad, J. Kania, S. Kiehlmann, G. N. Kimeridze, E. N. Kopatskaya, M. Kopp, M. Korte, B. Kotas, S. Koyama, J. A. Kramer, L. Kunkel, S. O. Kurtanidze, O. M. Kurtanidze, A. Lähteenmäki, J. M. López, V. M. Larionov, E. G. Larionova, L. V. Larionova, C. Leto, C. Lorey, R. Mújica, G. M. Madejski, N. Marchili, A. P. Marscher, M. Minev, A. Modaressi, D. A. Morozova, T. Mufakharov, I. Myserlis, A. A. Nikiforova, M. G. Nikolashvili, E. Ovcharov, M. Perri, C. M. Raiteri, A. C. S. Readhead, A. Reimer, D. Reinhart, S. Righini, K. Rosenlehner, A. C. Sadun, S. S. Savchenko, A. Scherbantin, L. Schneider, K. Schoch, D. Seifert, E. Semkov, L. A. Sigua, C. Singh, P. Sola, Y. Sotnikova, M. Spencer, R. Steineke, M. Stojanovic, A. Strigachev, M. Tornikoski, E. Traianou, A. Tramacere, Yu. V. Troitskaya, I. S. Troitskiy, J. B. Trump, A. Tsai, A. Valcheva, A. A. Vasilyev, F. Verrecchia, M. Villata, O. Vince, K. Vrontaki, Z. R. Weaver, E. Zaharieva, N. Zottmann

Publikováno v: The Astrophysical Journal Supplement Series, Vol 266, Iss 2, p 37 (2023)

We study the broadband emission of Mrk 501 using multiwavelength observations from 2017 to 2020 performed with a multitude of instruments, involving, among others, MAGIC, Fermi's Large Area Telescope (LAT), NuSTAR, Swift, GASP-WEBT, and the Owens Val

Externí odkaz: https://doaj.org/article/effe791e7795408ebde669353f2928b3

Testing of the mutagenic potential of N-(γ-aminobuturyl)-1-aza-15-crown-5 hydrochloride in Ames test microplate modification

Autor: M. Ya. Golovenko, V. B. Larionov, S. S. Basok, A. S. Reder

Publikováno v: Фармацевтичний журнал, Vol 2, Iss 2, Pp 81-87 (2019)

In recent years, studies in the field of chemical mutagenesis have undergone significant development, due to the introduction of a large number of different chemicals and scientific advances in the creation and use of new test systems, allowing a com

Externí odkaz: https://doaj.org/article/b6be0e842f054ffc988b8504a50230d0