Zobrazeno 1 - 10
of 54
pro vyhledávání: '"V A, Kobliakov"'
Autor:
V. A. Kobliakov
Publikováno v:
Успехи молекулярной онкологии, Vol 5, Iss 4, Pp 64-71 (2019)
The basic characteristics of tumours are ability for invasiveness and metastasis. These properties are realized due to destruction of intercellular matrix caused with acidification of intercellular area stimulated with transition from tissue respirat
Externí odkaz:
https://doaj.org/article/73ff7d980ee34582aece664bba2bdbea
Autor:
V. A. Kobliakov
Publikováno v:
Cell and Tissue Biology. 16:114-120
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c17a6252f2bb70b8cf6e1a64334585c2
https://doi.org/10.1134/s1990519x22020079
https://doi.org/10.1134/s1990519x22020079
Autor:
V A Kobliakov
Publikováno v:
Biochemistry. Biokhimiia. 84(10)
According to modern concepts, tumor formation is associated with impairments in the structure of protooncogenes and/or deactivation of suppressor genes, regardless of the nature of carcinogenic factor. As a consequence, unregulated oncoproteins activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2c1785b920a730ad07d49e0f6c0e6a
https://pubmed.ncbi.nlm.nih.gov/31694508
https://pubmed.ncbi.nlm.nih.gov/31694508
Autor:
V A, Kobliakov
Publikováno v:
Tsitologiia. 58(7)
The review deals with the role of hypoxia and glycolysis in the development of cancer. Experimental results demonstrate that the function of glycolysis in tumour cells is not limited to providing energy. Glycolysis stimulates the activity of transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cff36a7fdebd4e0da9d106779c99e645
https://pubmed.ncbi.nlm.nih.gov/30198655
https://pubmed.ncbi.nlm.nih.gov/30198655
Autor:
V. A. Kobliakov
Publikováno v:
Biochemistry. Biokhimiia. 82(4)
One of the differences between normal and cancer cells is lower pH of the extracellular space in tumors. Low pH in the extracellular space activates proteases and stimulates tumor invasion and metastasis. Tumor cells display higher level of the HIF1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd8763c7aaf3b062aeae13637a4444a
https://pubmed.ncbi.nlm.nih.gov/28371597
https://pubmed.ncbi.nlm.nih.gov/28371597
Publikováno v:
Cell and Tissue Biology. 7:329-334
To study the tumour-promotion activity of cell environment the transformed embryonic rat fibroblasts (clone CL-1-1) were transfect to immunodeficient mice then the cells of the formed tumour were cultivated (clone CL-1-1). The cells before and after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aab20189cdce31486c80f65b2aff9f3
https://doi.org/10.1134/s1990519x1304007x
https://doi.org/10.1134/s1990519x1304007x
Autor:
V. A. Kobliakov, M. S. Volkov
Publikováno v:
Cell and Tissue Biology. 5:378-382
The activation of NF-kB transcription factor produced by carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo/a/pyrene (BP) and 3-methylcholanthrene (MC) in cells with (human hepatoma HepG2) or without (rat hepatoma G27) the expression of the A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02913d32e3619d3578f0bc029ca62e03
https://doi.org/10.1134/s1990519x11040122
https://doi.org/10.1134/s1990519x11040122
Autor:
V. A. Kobliakov
Publikováno v:
Biochemistry (Moscow). 75:675-685
This review analyzes the available information concerning mechanisms of non-genotoxic action of reactive oxygen species (ROS) during tumor promotion and pathways of their generation under the influence of chemical compounds. Special attention is give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718c5ee8377388cae98bb679dd0edde6
https://doi.org/10.1134/s0006297910060015
https://doi.org/10.1134/s0006297910060015
Publikováno v:
Biochemistry (Moscow). 74:1228-1233
The differentiation status of fibroblasts can be characterized by their ability to induce Ah-receptor-dependent genes. The ability to induce Ah-receptor-dependent genes encoding cytochrome P450 isoforms, Ah-receptor repressor, and NADPH-quinine oxido
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72ccd2a60ee9448b08a79e689e1f07a
https://doi.org/10.1134/s000629790911008x
https://doi.org/10.1134/s000629790911008x
Publikováno v:
Cell and Tissue Biology. 3:243-248
Gap junction intercellular communication (GJIC) is a system that regulates tissue homeostasis. It is generally accepted that GJIC down-regulation is linked to carcinogen tumor-promoting properties. The effect of carcinogenic polycyclic aromatic hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90919d4758b7baf2f4d209c309abd65c
https://doi.org/10.1134/s1990519x09030055
https://doi.org/10.1134/s1990519x09030055