Zobrazeno 1 - 10
of 31
pro vyhledávání: '"V A, Beliavskaia"'
Publikováno v:
Zhurnal mikrobiologii, epidemiologii i immunobiologii. (3)
The characterization of known Salmonella vaccine strains and different attenuated mutants used for developing new vaccines is presented. The use of attenuated Salmonella strains as vaccine vector for the supply of heterologous antigens opens prospect
Autor:
V A, Beliavskaia, T A, Kashperova, V M, Bondarenko, A A, Il'ichev, I B, Sorokulova, N I, Malik
Publikováno v:
Zhurnal mikrobiologii, epidemiologii i immunobiologii. (2)
The in vitro and in vivo evaluation of the biological and ecological safety of genetically modified bacteria (GMB) was carried out on B. subtilis recombinant strain 2335/105, capable of producing human interferon alpha-2, used as experimental model.
Publikováno v:
Molekuliarnaia genetika, mikrobiologiia i virusologiia. (2)
Experimental strategy has been developed for selection of mismatched DNA binding phages from library of E. coli f1 filamentous phages carrying random peptide inserts on the surface of bacteriophage particles. The strategy is based on the use of phage
Autor:
V A, Beliavskaia, I V, Timofeev, N G, Perminova, T F, Paletskaia, E M, Kozhina, S N, Zagrebel'nyĭ
Publikováno v:
Molekuliarnaia genetika, mikrobiologiia i virusologiia. (3)
The capacity of a previously described plasmid vector pAZ to deliver bioactive proteins to targets in vivo has been studied. This vector molecule has a strong constitutive promoter, is extremely stable in cells of vaccinal S. choleraesuis strain, and
Autor:
V M, Bondarenko, V A, Beliavskaia
Publikováno v:
Zhurnal mikrobiologii, epidemiologii i immunobiologii. (2)
The possibility of using the genera Lactobacillus and Lactococcus as vector representatives is widely discussed at present. The prospects of the construction of recombinant bacteria are closely connected with the solution of a number of problems: the
Publikováno v:
Mikrobiologiia. 67(2)
Expression of the lux-genes cloned on the recombinant plasmid pPHL7 (AprLux+) in Escherichia coli z905 cells was studied in various environments, including model aquatic ecosystems. Expression of the lux-genes strongly depended on the nutritional sta
Publikováno v:
Vestnik Rossiiskoi akademii meditsinskikh nauk. (4)
The paper briefly reviews a study on the design of drugs enhancing the body's nonspecific resistance to pathogenic agents. To examine the potential regulatory effects on cytokine function was a main trend. The interferon inductor ridostin, dsRNA of m
Publikováno v:
Mikrobiologiia. 66(6)
Adaptation of the Bacillus subtilis strain 2335/105 (Km Inf+) containing a recombinant plasmid encoding the extracellular human interferon alpha 2 was studied under various conditions. Stability of the plasmid in the population of B. subtilis 2335/10
Publikováno v:
Vestnik Rossiiskoi akademii meditsinskikh nauk. (3)
Approaches to designing a new probiotic class based on recombinant strains of bacteria that produce the predetermined therapeutic proteins are dealt with. The prospects of the approach are shown via studies of the biological properties of Bacillus su
Autor:
V A, Beliavskaia, A I, Zakabunin, I N, Dolgova, S I, Belikov, K N, Verevkina, I I, Krasnoborov
Publikováno v:
Molekuliarnaia genetika, mikrobiologiia i virusologiia. (6)
High-level expression vector pAZ was constructed for in vivo delivery of bioactive recombinant proteins, antigenic determinants, among other things. This vector meets the requirements to construction of recombinant bacteria as live oral carriers. It