Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Vγ9Vδ2 T cells"'
Autor:
Jian Liu, Min Wu, Yifan Yang, Xinyu Mei, Liming Wang, Jingyu Wang, Zixuan Wang, Shan He, Hangyu Liu, Han Jiang, Shen Qu, Yuwei Zhang, Ying Chen, Xun Tian, Yafei Huang, Hui Wang
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Clinical trials have shown that immunotherapy based on Vγ9Vδ2 T cells (Vδ2 T cells) is safe and well-tolerated for various cancers including cervical cancer (CC), but its overall treatment efficacy remains limited. Therefore, e
Externí odkaz:
https://doaj.org/article/55b102c0746543a88b6f2bc28deb4dd8
Autor:
Lisa A. King, Milon de Jong, Myrthe Veth, David Lutje Hulsik, Parsa Yousefi, Victoria Iglesias-Guimarais, Pauline M. van Helden, Tanja D. de Gruijl, Hans J. van der Vliet
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundVγ9Vδ2 T-cells are antitumor immune effector cells that can detect metabolic dysregulation in cancer cells through phosphoantigen-induced conformational changes in the butyrophilin (BTN) 2A1/3A1 complex. In order to clinically exploit the
Externí odkaz:
https://doaj.org/article/3eb04d8fffbe403ba273566ef54bbcbc
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The nucleotide-binding and oligomerization domain-like receptors (NLRs) NLR family CARD domain-containing protein 5 (NLRC5) and Class II Major Histocompatibility Complex Transactivator (CIITA) are transcriptional regulators of major histocompatibilit
Externí odkaz:
https://doaj.org/article/927c3d47eb6a418fa84e079df55b3301
Autor:
Yi Wang, Nan Ji, Yang Zhang, Junsheng Chu, Changcun Pan, Peng Zhang, Weiwei Ma, Xueguang Zhang, Jianzhong Jeff Xi, Mingze Chen, Yonghui Zhang, Liwei Zhang, Tao Sun
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Glioblastoma (GBM) is a highly aggressive primary brain tumor with a poor prognosis. This study investigates the therapeutic potential of human Vγ9Vδ2 T cells in GBM treatment. The sensitivity of different glioma specimens to V
Externí odkaz:
https://doaj.org/article/15cf40ea1570401ea7a8f1bd3e43623f
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
γδ T cells, with their properties of both the innate and acquired immune systems, are suitable candidates for cellular immunotherapy in cancer. Because of their non-major histocompatibility complex (MHC) binding T cell receptor, allogenic transfer
Externí odkaz:
https://doaj.org/article/d558f5dfb8d44b8ba2b51138ffed680f
Autor:
Jack Firth, Jingjing Sun, Vaques George, Jian-Dong Huang, Mona Bajaj-Elliott, Kenth Gustafsson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundIncreasing evidence suggests the immune activation elicited by bacterial outer-membrane vesicles (OMVs) can initiate a potent anti-tumor immunity, facilitating the recognition and destruction of malignant cells. At present the pathways unde
Externí odkaz:
https://doaj.org/article/0746bb8c3b1349228f59a89d23573448
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In the last years, the tumor microenvironment (TME) has emerged as a promising target for therapeutic interventions in cancer. Cancer cells are highly dependent on the TME to growth and evade the immune system. Three major cell subpopulations are fac
Externí odkaz:
https://doaj.org/article/8ce8e6ff3cc34a5dac524eda9c72addb
Autor:
Claudia Giannotta, Barbara Castella, Ezio Tripoli, Daniele Grimaldi, Ilaria Avonto, Mattia D’Agostino, Alessandra Larocca, Joanna Kopecka, Mariella Grasso, Chiara Riganti, Massimo Massaia
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionBone marrow (BM) Vγ9Vδ2 T cells are intrinsically predisposed to sense the immune fitness of the tumor microenvironment (TME) in multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS).MethodsIn this work, we
Externí odkaz:
https://doaj.org/article/2c1d4e5bf75f47d1859e683fe66f6ca6
Akademický článek
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