Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Vγ2Vδ2 T cells"'
Autor:
Hongbo Shen, Enzhuo Yang, Ming Guo, Rui Yang, Guixian Huang, Ying Peng, Wei Sha, Feifei Wang, Ling Shen
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1790-1805 (2022)
Multidrug-resistant tuberculosis (MDR-TB) is a refractory disease with high mortality rate due to no or few choices of antibiotics. Adjunctive immunotherapy may help improve treatment outcome of MDR-TB. Our decade-long studies demonstrated that phosp
Externí odkaz:
https://doaj.org/article/2b385f7016194a1ead1a50f85136bb6a
Autor:
Jiang Pi, Zhiyi Zhang, Enzhuo Yang, Lingming Chen, Lingchan Zeng, Yiwei Chen, Richard Wang, Dan Huang, Shuhao Fan, Wensen Lin, Hongbo Shen, Jun-Fa Xu, Gucheng Zeng, Ling Shen
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-21 (2022)
Abstract Tuberculosis (TB), induced by Mycobacterium tuberculosis (Mtb) infection, remains a top killer among infectious diseases. While Bacillus Calmette-Guerin (BCG) is the sole TB vaccine, the clumped-clustered features of BCG in intradermal immun
Externí odkaz:
https://doaj.org/article/097309d3344d4816a9452904a23d4097
Autor:
Rui Yang, Susu Shen, Cheng Gong, Xin Wang, Fang Luo, Fengyan Luo, Yang Lei, Zili Wang, Shasha Xu, Qian Ni, Yan Xue, Zhen Fu, Liang Zeng, Lijuan Fang, Yongxiang Yan, Jing Zhang, Lu Gan, Jizu Yi, Pengfei Zhou
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Vγ2Vδ2 T cell-based immunotherapy has benefited some patients in clinical trials, but the overall efficacy is low for solid tumor patients. In this study, a bispecific antibody against both PD-L1 and CD3 (PD-L1 x CD3), Y111, could efficiently bridg
Externí odkaz:
https://doaj.org/article/ecf503bdba27439e8c9d1fed98446485
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Human Vγ2Vδ2 (also termed Vγ9Vδ2) T cells play important roles in microbial and tumor immunity by monitoring foreign- and self-prenyl pyrophosphate metabolites in isoprenoid biosynthesis. Accumulation of isoprenoid metabolites after bisphosphonat
Externí odkaz:
https://doaj.org/article/44888b298b5348eaa2d0982d33df0a10
Autor:
Daisuke Okuno, Yuki Sugiura, Noriho Sakamoto, Mohammed S. O. Tagod, Masashi Iwasaki, Shuto Noda, Akihiro Tamura, Hiroaki Senju, Yasuhiro Umeyama, Hiroyuki Yamaguchi, Makoto Suematsu, Craig T. Morita, Yoshimasa Tanaka, Hiroshi Mukae
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Increasing attention has been paid to human γδ T cells expressing Vγ2Vδ2 T cell receptor (also termed Vγ9Vδ2) in the field of cancer immunotherapy. We have previously demonstrated that a novel bisphosphonate prodrug, tetrakis-pivaloyloxymethyl
Externí odkaz:
https://doaj.org/article/02142f0fc54e475fb2d9290f2b7ef0f4
Publikováno v:
BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-8 (2018)
Abstract Background It is not fully explained why some active tuberculosis patients show negative interferon-γ release assays (IGRAs). In this study, we tried to explore associations of IGRAs with the characteristics of peripheral Vγ2Vδ2 T cells a
Externí odkaz:
https://doaj.org/article/f35b631508cd488984f9f3f0fdeb3edc
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/3ae77bbe24e3443aa3087d049e02d619
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
While IL-12 plays a key role in differentiation of protective CD4+ Th1 response, little is known about mechanisms whereby IL-12 differentiates other T-cell populations. Published studies suggest that predominant Vγ2Vδ2 T cells in humans/nonhuman pr
Externí odkaz:
https://doaj.org/article/c8aece847727486e993e643e4e3095c5
Autor:
Lu, Jingwei a, Das, Manjusri a, Kanji, Suman a, Aggarwal, Reeva a, Joseph, Matthew a, Ray, Alo a, Shapiro, Charles L. b, Pompili, Vincent J. a, Das, Hiranmoy a, c, ⁎
Publikováno v:
In BBA - Molecular Basis of Disease July 2014 1842(7):1071-1079
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