Výsledky vyhledávání - "Vγ2Vδ2 T cells"

Akademický článek

Bispecific Antibody PD-L1 x CD3 Boosts the Anti-Tumor Potency of the Expanded Vγ2Vδ2 T Cells

Autor: Rui Yang, Susu Shen, Cheng Gong, Xin Wang, Fang Luo, Fengyan Luo, Yang Lei, Zili Wang, Shasha Xu, Qian Ni, Yan Xue, Zhen Fu, Liang Zeng, Lijuan Fang, Yongxiang Yan, Jing Zhang, Lu Gan, Jizu Yi, Pengfei Zhou

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Vγ2Vδ2 T cell-based immunotherapy has benefited some patients in clinical trials, but the overall efficacy is low for solid tumor patients. In this study, a bispecific antibody against both PD-L1 and CD3 (PD-L1 x CD3), Y111, could efficiently bridg

Externí odkaz: https://doaj.org/article/ecf503bdba27439e8c9d1fed98446485

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Akademický článek

Antigens in Tea-Beverage Prime Human Vγ2Vδ2 T Cells in vitro and in vivo for Memory and Nonmemory Antibacterial Cytokine Responses

Autor: Kamath, Arati B., Wang, Lisheng, Das, Hiranmoy, Li, Lin, Reinhold, Vernon N., Bukowski, Jack F.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2003 May . 100(10), 6009-6014.

Externí odkaz: https://www.jstor.org/stable/3147533

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Akademický článek

PD-1 checkpoint blockade enhances adoptive immunotherapy by human Vγ2Vδ2 T cells against human prostate cancer

Autor: Mohanad H. Nada, Hong Wang, Auter J. Hussein, Yoshimasa Tanaka, Craig T. Morita

Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)

Human Vγ2Vδ2 (also termed Vγ9Vδ2) T cells play important roles in microbial and tumor immunity by monitoring foreign- and self-prenyl pyrophosphate metabolites in isoprenoid biosynthesis. Accumulation of isoprenoid metabolites after bisphosphonat

Externí odkaz: https://doaj.org/article/44888b298b5348eaa2d0982d33df0a10

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Akademický článek

Comparison of a Novel Bisphosphonate Prodrug and Zoledronic Acid in the Induction of Cytotoxicity in Human Vγ2Vδ2 T Cells

Autor: Daisuke Okuno, Yuki Sugiura, Noriho Sakamoto, Mohammed S. O. Tagod, Masashi Iwasaki, Shuto Noda, Akihiro Tamura, Hiroaki Senju, Yasuhiro Umeyama, Hiroyuki Yamaguchi, Makoto Suematsu, Craig T. Morita, Yoshimasa Tanaka, Hiroshi Mukae

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Increasing attention has been paid to human γδ T cells expressing Vγ2Vδ2 T cell receptor (also termed Vγ9Vδ2) in the field of cancer immunotherapy. We have previously demonstrated that a novel bisphosphonate prodrug, tetrakis-pivaloyloxymethyl

Externí odkaz: https://doaj.org/article/02142f0fc54e475fb2d9290f2b7ef0f4

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Akademický článek

Characteristics of peripheral Vγ2Vδ2 T cells in interferon-γ release assay negative pulmonary tuberculosis patients

Autor: Liping Yan, Hongbo Shen, Heping Xiao

Publikováno v: BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-8 (2018)

Abstract Background It is not fully explained why some active tuberculosis patients show negative interferon-γ release assays (IGRAs). In this study, we tried to explore associations of IGRAs with the characteristics of peripheral Vγ2Vδ2 T cells a

Externí odkaz: https://doaj.org/article/f35b631508cd488984f9f3f0fdeb3edc

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