17-β estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms

Autor: Federica Filice, Emanuel Lauber, Karl Jakob Vörckel, Markus Wöhr, Beat Schwaller

Publikováno v: Molecular Autism, Vol 9, Iss 1, Pp 1-13 (2018)

Abstract Background Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by two core symptoms: impaired social interaction and communication, and restricted, repetitive behaviors and interests. The pathophysiology o

Externí odkaz: https://doaj.org/article/f5bd04259f1f44c381b52d073ff14ad5

17-β estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms

Autor: Emanuel Lauber, Beat Schwaller, Karl Jakob Vörckel, Federica Filice, Markus Wöhr

Publikováno v: Molecular Autism, Vol 9, Iss 1, Pp 1-13 (2018)

BACKGROUND: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by two core symptoms: impaired social interaction and communication, and restricted, repetitive behaviors and interests. The pathophysiology of ASD is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a45a5b72da26143d6c6c41bf48d102
http://link.springer.com/article/10.1186/s13229-018-0199-3

Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice

Autor: Michaela Schweizer, Karl Jakob Vörckel, Vanessa Kraus, Mariya V. Hrynchak, Claudia Schob, Julia Calzada-Wack, Craig C. Garner, Irm Herrmans-Borgmeyer, Valerie Gailus-Durner, Martin Hrabě de Angelis, Henrike Hartung, Marco D. Brockmann, Hans-Jürgen Kreienkamp, Fabio Morellini, Ora Ohana, Helmut Fuchs, Dietmar Kuhl, Ileana L. Hanganu-Opatz, Nicole Cichon, Markus Wöhr, Sarah Scharf, Stefan Kindler, Roland Brandt, Lidia Bakota

Publikováno v: Translational Psychiatry 9(1), 7 (2019). doi:10.1038/s41398-018-0327-z
Translational Psychiatry
Translational Psychiatry, Vol 9, Iss 1, Pp 1-19 (2019)
Transl. Psychiatry 9:7 (2019)

In humans, genetic variants of DLGAP1-4 have been linked with neuropsychiatric conditions, including autism spectrum disorder (ASD). While these findings implicate the encoded postsynaptic proteins, SAPAP1-4, in the etiology of neuropsychiatric condi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f184752bc6898b5b9929d50dbb09d53
https://pub.dzne.de/record/140779

Additional file 1: of 17-β estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms

Autor: Filice, Federica, Lauber, Emanuel, Vörckel, Karl, Wöhr, Markus, Schwaller, Beat

Supplemental information on experimental details. Figure S1 A) Details on mouse husbandry and B) selection of the tested mice. Figure S2 Methodological details on mouse handling, E2 administration and mouse weights. Figure S3 Results from 3-chamber s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d52dcc7a15e886a3fe98b4ed6aa4f63

Repetitive behaviors in the Shank1 knockout mouse model for autism spectrum disorder: Developmental aspects and effects of social context

Autor: Rainer K.W. Schwarting, A. Özge Sungur, Karl Jakob Vörckel, Markus Wöhr

Publikováno v: Journal of Neuroscience Methods. 234:92-100

Background Autism spectrum disorder (ASD) is characterized by persistent deficits in social behavior and communication, together with restricted and repetitive patterns of behavior. Several ASD candidate genes have been identified, including the SHAN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f706c57a4e5bfeaf5d1b42983702d7e7
https://doi.org/10.1016/j.jneumeth.2014.05.003