A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling.

Autor: Patterson HC; Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115; Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine, Cambridge, MA 02139; Institut fuer Klinische Chemie und Biochemie, Klinikum rechts der Isar, 81675 Munich, Germany; ckunst@partners.org lodish@wi.mit.edu., Gerbeth C; Institute for Biochemistry and Molecular Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany;, Thiru P; Whitehead Institute for Biomedical Research, Cambridge, MA 02142;, Vögtle NF; Institute for Biochemistry and Molecular Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany;, Knoll M; Whitehead Institute for Biomedical Research, Cambridge, MA 02142;, Shahsafaei A; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115;, Samocha KE; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114; Broad Institute, Cambridge, MA 02142;, Huang CX; Whitehead Institute for Biomedical Research, Cambridge, MA 02142;, Harden MM; Whitehead Institute for Biomedical Research, Cambridge, MA 02142;, Song R; Whitehead Institute for Biomedical Research, Cambridge, MA 02142;, Chen C; Whitehead Institute for Biomedical Research, Cambridge, MA 02142;, Kao J; Whitehead Institute for Biomedical Research, Cambridge, MA 02142;, Shi J; Whitehead Institute for Biomedical Research, Cambridge, MA 02142;, Salmon W; Whitehead Institute for Biomedical Research, Cambridge, MA 02142;, Shaul YD; Whitehead Institute for Biomedical Research, Cambridge, MA 02142;, Stokes MP; Cell Signaling Technology, Danvers, MA 01923;, Silva JC; Cell Signaling Technology, Danvers, MA 01923;, Bell GW; Whitehead Institute for Biomedical Research, Cambridge, MA 02142;, MacArthur DG; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114; Broad Institute, Cambridge, MA 02142;, Ruland J; Institut fuer Klinische Chemie und Biochemie, Klinikum rechts der Isar, 81675 Munich, Germany;, Meisinger C; Institute for Biochemistry and Molecular Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany;, Lodish HF; Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142 ckunst@partners.org lodish@wi.mit.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Oct 20; Vol. 112 (42), pp. E5679-88. Date of Electronic Publication: 2015 Oct 05.