Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Vítezslav Bryja"'
Autor:
Terezia Kurucova, Kamila Reblova, Pavlina Janovska, Jakub Pawel Porc, Veronika Navrkalova, Sarka Pavlova, Jitka Malcikova, Karla Plevova, Boris Tichy, Michael Doubek, Vitezslav Bryja, Jana Kotaskova, Sarka Pospisilova
Publikováno v:
Molecular Oncology, Vol 18, Iss 10, Pp 2541-2553 (2024)
Early identification of resistant cancer cells is currently a major challenge, as their expansion leads to refractoriness. To capture the dynamics of these cells, we made a comprehensive analysis of disease progression and treatment response in a chr
Externí odkaz:
https://doaj.org/article/c833416f75ab4151874dbe6f3b782ba0
Autor:
Senem Ntourmas, Martin Sachs, Petra Paclíková, Martina Brückner, Vítězslav Bryja, Jürgen Behrens, Dominic B Bernkopf
Publikováno v:
eLife, Vol 13 (2024)
Activation of the Wnt/β-catenin pathway crucially depends on the polymerization of dishevelled 2 (DVL2) into biomolecular condensates. However, given the low affinity of known DVL2 self-interaction sites and its low cellular concentration, it is unc
Externí odkaz:
https://doaj.org/article/d5b61e976be743fca0a2384c105e1095
Autor:
Markéta Pícková, Zuzana Kahounová, Tomasz Radaszkiewicz, Jiřina Procházková, Radek Fedr, Michaela Nosková, Katarzyna Anna Radaszkiewicz, Petra Ovesná, Vítězslav Bryja, Karel Souček
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Metastatic melanoma, a highly lethal form of skin cancer, presents significant clinical challenges due to limited therapeutic options and high metastatic capacity. Recent studies have demonstrated that cancer dissemination can occur earlier,
Externí odkaz:
https://doaj.org/article/e0bd277f452f4f1b9cbd5f9d9804c57b
Autor:
Viktória Parobková, Petra Kompaníková, Jakub Lázňovský, Michaela Kavková, Marek Hampl, Marcela Buchtová, Tomáš Zikmund, Jozef Kaiser, Vítězslav Bryja
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract The Hindbrain Choroid Plexus is a complex, cerebrospinal fluid-secreting tissue that projects into the 4th vertebrate brain ventricle. Despite its irreplaceability in the development and homeostasis of the entire central nervous system, the
Externí odkaz:
https://doaj.org/article/3923dc378a8e47589f4bdb619ee05e47
Autor:
Anna Vyhlídalová Kotrbová, Kristína Gömöryová, Antónia Mikulová, Hana Plešingerová, Stanislava Sladeček, Marek Kravec, Šárka Hrachovinová, David Potěšil, Garett Dunsmore, Camille Blériot, Mathilde Bied, Jan Kotouček, Markéta Bednaříková, Jitka Hausnerová, Luboš Minář, Igor Crha, Michal Felsinger, Zbyněk Zdráhal, Florent Ginhoux, Vít Weinberger, Vitězslav Bryja, Vendula Pospíchalová
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 3, Pp n/a-n/a (2024)
Abstract High‐grade serous carcinoma of the ovary, fallopian tube and peritoneum (HGSC), the most common type of ovarian cancer, ranks among the deadliest malignancies. Many HGSC patients have excess fluid in the peritoneum called ascites. Ascites
Externí odkaz:
https://doaj.org/article/dc1667b33f2d4fcab8e36f032b4b3b53
Autor:
Julian Petersen, Lukas Englmaier, Artem V. Artemov, Irina Poverennaya, Ruba Mahmoud, Thibault Bouderlique, Marketa Tesarova, Ruslan Deviatiiarov, Anett Szilvásy-Szabó, Evgeny E. Akkuratov, David Pajuelo Reguera, Hugo Zeberg, Marketa Kaucka, Maria Eleni Kastriti, Jan Krivanek, Tomasz Radaszkiewicz, Kristína Gömöryová, Sarah Knauth, David Potesil, Zbynek Zdrahal, Ranjani Sri Ganji, Anna Grabowski, Miriam E. Buhl, Tomas Zikmund, Michaela Kavkova, Håkan Axelson, David Lindgren, Rafael Kramann, Christoph Kuppe, Ferenc Erdélyi, Zoltán Máté, Gábor Szabó, Till Koehne, Tibor Harkany, Kaj Fried, Jozef Kaiser, Peter Boor, Csaba Fekete, Jan Rozman, Petr Kasparek, Jan Prochazka, Radislav Sedlacek, Vitezslav Bryja, Oleg Gusev, Igor Adameyko
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik/C14orf105/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually hi
Externí odkaz:
https://doaj.org/article/28aaada8bdf44462afbe36b53f7e9fc6
Autor:
Lucie Poppova, Sarka Pavlova, Beatriz Gonzalez, Jana Kotaskova, Karla Plevova, Gabrijela Dumbovic, Pavlina Janovska, Vojtech Bystry, Anna Panovska, Lucie Bezdekova, Stanislava Maslejova, Yvona Brychtova, Michael Doubek, Marcela Krzyzankova, Marek Borsky, Jiri Mayer, Vitezslav Bryja, Sergio Alonso, Sarka Pospisilova
Publikováno v:
Epigenetics, Vol 17, Iss 12, Pp 1628-1635 (2022)
Genome methylation profiles define naïve-like (n-CLL), memory-like (m-CLL), and intermediate (i-CLL) subsets of chronic lymphocytic leukaemia (CLL). The profiles can be easily determined by the analysis of the five-CpG signature. m-CLL, i-CLL, and n
Externí odkaz:
https://doaj.org/article/2ac6200ffdb247bbae9278ab0e3327a5
Autor:
Julian Petersen, Lukas Englmaier, Artem V. Artemov, Irina Poverennaya, Ruba Mahmoud, Thibault Bouderlique, Marketa Tesarova, Ruslan Deviatiiarov, Anett Szilvásy-Szabó, Evgeny E. Akkuratov, David Pajuelo Reguera, Hugo Zeberg, Marketa Kaucka, Maria Eleni Kastriti, Jan Krivanek, Tomasz Radaszkiewicz, Kristína Gömöryová, Sarah Knauth, David Potesil, Zbynek Zdrahal, Ranjani Sri Ganji, Anna Grabowski, Miriam E. Buhl, Tomas Zikmund, Michaela Kavkova, Håkan Axelson, David Lindgren, Rafael Kramann, Christoph Kuppe, Ferenc Erdélyi, Zoltán Máté, Gábor Szabó, Till Koehne, Tibor Harkany, Kaj Fried, Jozef Kaiser, Peter Boor, Csaba Fekete, Jan Rozman, Petr Kasparek, Jan Prochazka, Radislav Sedlacek, Vitezslav Bryja, Oleg Gusev, Igor Adameyko
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/3300b54bdc8f4238b2b03a29eb7a2ad1
Autor:
Hana Plešingerová, Pavlína Janovská, Archana Mishra, Lucie Smyčková, Lucie Poppová, Antonín Libra, Karla Plevová, Petra Ovesná, Lenka Radová, Michael Doubek, Šárka Pavlová, Šárka Pospíšilová, Vítězslav Bryja
Publikováno v:
Haematologica, Vol 103, Iss 2 (2018)
Chronic lymphocytic leukemia is a disease with up-regulated expression of the transmembrane tyrosine-protein kinase ROR1, a member of the Wnt/planar cell polarity pathway. In this study, we identified COBLL1 as a novel interaction partner of ROR1. CO
Externí odkaz:
https://doaj.org/article/87d9511f25d1443e86b7d22cc054bb28
To accomplish its role of signaling hub in all Wnt signaling pathways, Dishevelled (DVL) protein needs to dynamically relocalize to the inner leaflet of the cellular plasma membrane (PM). Combined experimental and computational evidence showed that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d37ef93f66981bd2bb94df390cc5a680
https://doi.org/10.1101/2023.01.27.525887
https://doi.org/10.1101/2023.01.27.525887
