Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Vítězslav Bryja"'
Autor:
Markéta Pícková, Zuzana Kahounová, Tomasz Radaszkiewicz, Jiřina Procházková, Radek Fedr, Michaela Nosková, Katarzyna Anna Radaszkiewicz, Petra Ovesná, Vítězslav Bryja, Karel Souček
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Metastatic melanoma, a highly lethal form of skin cancer, presents significant clinical challenges due to limited therapeutic options and high metastatic capacity. Recent studies have demonstrated that cancer dissemination can occur earlier,
Externí odkaz:
https://doaj.org/article/e0bd277f452f4f1b9cbd5f9d9804c57b
Autor:
Viktória Parobková, Petra Kompaníková, Jakub Lázňovský, Michaela Kavková, Marek Hampl, Marcela Buchtová, Tomáš Zikmund, Jozef Kaiser, Vítězslav Bryja
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract The Hindbrain Choroid Plexus is a complex, cerebrospinal fluid-secreting tissue that projects into the 4th vertebrate brain ventricle. Despite its irreplaceability in the development and homeostasis of the entire central nervous system, the
Externí odkaz:
https://doaj.org/article/3923dc378a8e47589f4bdb619ee05e47
Autor:
Štěpán Čada, Olga Vondálová Blanářová, Kristína Gömoryová, Antónia Mikulová, Petra Bačovská, Nikodém Zezula, Alka Kumari Jadaun, Pavlína Janovská, Hana Plešingerová, Vítězslav Bryja
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The migratory properties of leukemic cells are commonly associated with their pathological potential and can significantly affect the disease progression. While the research in immunopathology mostly employed powerful indirect methods such as flow cy
Externí odkaz:
https://doaj.org/article/fffa7f58808f4be6a911654bb32be784
Autor:
Miroslav Jurásek, Jitender Kumar, Petra Paclíková, Alka Kumari, Konstantinos Tripsianes, Vítězslav Bryja, Robert Vácha
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The PDZ domain of Dishevelled 3 protein belongs to a highly abundant protein recognition motif which typically binds short C-terminal peptides. The affinity of the PDZ towards the peptides could be fine-tuned by a variety of post-translation
Externí odkaz:
https://doaj.org/article/69a71e109e3e4b98bed52b98a56b9089
Autor:
Zankruti Dave, Olga Vondálová Blanářová, Štěpán Čada, Pavlína Janovská, Nikodém Zezula, Martin Běhal, Kateřina Hanáková, Sri Ranjani Ganji, Pavel Krejci, Kristína Gömöryová, Helena Peschelová, Michal Šmída, Zbyněk Zdráhal, Šárka Pavlová, Jana Kotašková, Šárka Pospíšilová, Vítězslav Bryja
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of ROR1, the cell surface receptor for Wnt-5a. Both, BCR and ROR1 are the
Externí odkaz:
https://doaj.org/article/f859b8e261ed419caa9d076a1db931a2
Autor:
Tomasz Radaszkiewicz, Vítězslav Bryja
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract Background RNF43 and its homolog ZNRF3 are transmembrane E3 ubiquitin ligases frequently mutated in many human cancer types. Their main role relays on the inhibition of canonical Wnt signaling by the negative regulation of frizzled receptors
Externí odkaz:
https://doaj.org/article/be6b85602f934a9194ca4fe3d581a400
Autor:
Kateřina Hanáková, Ondřej Bernatík, Marek Kravec, Miroslav Micka, Jitender Kumar, Jakub Harnoš, Petra Ovesná, Petra Paclíková, Matěj Rádsetoulal, David Potěšil, Konstantinos Tripsianes, Lukáš Čajánek, Zbyněk Zdráhal, Vítězslav Bryja
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-21 (2019)
Abstract Background Dishevelled (DVL) is an essential component of the Wnt signaling cascades. Function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose phosphorylation gene
Externí odkaz:
https://doaj.org/article/59bcf25501ed4898813e2a7a806d2bac
Autor:
Tomasz Radaszkiewicz, Michaela Nosková, Kristína Gömöryová, Olga Vondálová Blanářová, Katarzyna Anna Radaszkiewicz, Markéta Picková, Ráchel Víchová, Tomáš Gybeľ, Karol Kaiser, Lucia Demková, Lucia Kučerová, Tomáš Bárta, David Potěšil, Zbyněk Zdráhal, Karel Souček, Vítězslav Bryja
Publikováno v:
eLife, Vol 10 (2021)
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunopr
Externí odkaz:
https://doaj.org/article/429690658a42429e81ef4cee4109bc0b
Autor:
Jakub Harnoš, Maria Consuelo Alonso Cañizal, Miroslav Jurásek, Jitender Kumar, Cornelia Holler, Alexandra Schambony, Kateřina Hanáková, Ondřej Bernatík, Zbyněk Zdráhal, Kristína Gömöryová, Tomáš Gybeľ, Tomasz Witold Radaszkiewicz, Marek Kravec, Lukáš Trantírek, Jan Ryneš, Zankruti Dave, Ana Iris Fernández-Llamazares, Robert Vácha, Konstantinos Tripsianes, Carsten Hoffmann, Vítězslav Bryja
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Dishevelled (DVL) is the key component of Wnt signaling pathway that acts as a signaling hub. Here, authors study the conformational dynamics of DVL3 in vivo using their engineered FlAsH-based FRET biosensors and describe how Wnt activation opens DVL
Externí odkaz:
https://doaj.org/article/c656ec6d84244ea4ba47e39232d91995
Autor:
Karol Kaiser, Daniel Gyllborg, Jan Procházka, Alena Salašová, Petra Kompaníková, Francisco Lamus Molina, Rocio Laguna-Goya, Tomasz Radaszkiewicz, Jakub Harnoš, Michaela Procházková, David Potěšil, Roger A. Barker, Ángel Gato Casado, Zbyněk Zdráhal, Radislav Sedláček, Ernest Arenas, J. Carlos Villaescusa, Vítězslav Bryja
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
WNTs can signal over long distances but how this arises in the brain is unclear. Here, the authors show that WNT5A is secreted from the choroid plexus of the developing hindbrain (but not the telencephalon) and transported in the CSF with lipoprotein
Externí odkaz:
https://doaj.org/article/b5243ecd5bb74a85a22885abf4c818ed