Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Víctor Valcárcel-Hernández"'
Autor:
Marina Guillén-Yunta, Ángel García-Aldea, Víctor Valcárcel-Hernández, Ainara Sanz-Bógalo, Emma Muñoz-Moreno, Maria Gisele Matheus, Carmen Grijota-Martínez, Ana Montero-Pedrazuela, Ana Guadaño-Ferraz, Soledad Bárez-López
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106621- (2024)
Allan-Herndon-Dudley syndrome (AHDS) is a rare X-linked disorder that causes severe neurological damage, for which there is no effective treatment. AHDS is due to inactivating mutations in the thyroid hormone transporter MCT8 that impair the entry of
Externí odkaz:
https://doaj.org/article/00765c84013245a289fc2b187923a54b
Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and olfactory function in adult mice
Autor:
Víctor Valcárcel-Hernández, Pieter Vancamp, Lucile Butruille, Sylvie Remaud, Ana Guadaño-Ferraz
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106572- (2024)
Within the adult mouse subventricular zone (SVZ), neural stem cells (NSCs) produce neuroblasts and oligodendrocyte precursor cells (OPCs). T3, the active thyroid hormone, influences renewal and commitment of SVZ progenitors. However, how regulators o
Externí odkaz:
https://doaj.org/article/58830bacd02b482fa711f77b84eda268
Autor:
Ángel García-Aldea, Marina Guillén-Yunta, Víctor Valcárcel-Hernández, Ana Montero-Pedrazuela, Ana Guadaño-Ferraz, Soledad Bárez-López
Publikováno v:
European Thyroid Journal, Vol 13, Iss 2, Pp 1-9 (2024)
Thyroid hormones play an important role during the development and functioning of the different sensory systems. In order to exert their actions, thyroid hormones need to access their target cells through transmembrane transporter proteins, among whi
Externí odkaz:
https://doaj.org/article/930b764a158e4966b968db305a3dbaad
Autor:
Marina Guillén-Yunta, Víctor Valcárcel-Hernández, Ángel García-Aldea, Guadalupe Soria, José Manuel García-Verdugo, Ana Montero-Pedrazuela, Ana Guadaño-Ferraz
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Background The monocarboxylate transporter 8 (MCT8) plays a vital role in maintaining brain thyroid hormone homeostasis. This transmembrane transporter is expressed at the brain barriers, as the blood–brain barrier (BBB), and in neural cel
Externí odkaz:
https://doaj.org/article/0eeb6dae8d194ee1ad7e04172c78f784
Autor:
Víctor Valcárcel-Hernández, Marina Guillén-Yunta, Miranda Bueno-Arribas, Ana Montero-Pedrazuela, Carmen Grijota-Martínez, Suzy Markossian, Ángel García-Aldea, Frédéric Flamant, Soledad Bárez-López, Ana Guadaño-Ferraz
Publikováno v:
Neurobiology of Disease, Vol 174, Iss , Pp 105896- (2022)
Inactivating mutations in the specific thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to an X-linked rare disease named MCT8 deficiency or Allan-Herndon-Dudley Syndrome. Patients exhibit a plethora of severe endocrine and neuro
Externí odkaz:
https://doaj.org/article/272bf65832e14e22823ca721de1521f1
Autor:
Víctor Valcárcel-Hernández, Daniela López-Espíndola, Marina Guillén-Yunta, Ángel García-Aldea, Inés López de Toledo Soler, Soledad Bárez-López, Ana Guadaño-Ferraz
Publikováno v:
Neurobiology of Disease, Vol 162, Iss , Pp 105567- (2022)
Mutations in the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to profound brain alterations, including myelination impairments, in humans. We aimed to further explore the pathophysiological mechanisms underlying the MCT8 defi
Externí odkaz:
https://doaj.org/article/589a1f6799c14691a43c1635754f92f2
Autor:
Víctor Valcárcel-Hernández, Marina Guillén-Yunta, Thomas S. Scanlan, Soledad Bárez-López, Ana Guadaño-Ferraz
Publikováno v:
Thyroid. 33:632-640
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2243a5353100ffe8402984b1ee084f5e
https://doi.org/10.1089/thy.2022.0612
https://doi.org/10.1089/thy.2022.0612
Autor:
Soledad Bárez-López, Daniela López-Espíndola, Marina Guillén-Yunta, Ana Guadaño-Ferraz, Víctor Valcárcel-Hernández, Inés López de Toledo Soler, A. García-Aldea
Publikováno v:
Neurobiology of Disease, Vol 162, Iss, Pp 105567-(2022)
Valcárcel-Hernández, V, López-Espíndola, D, Guillén-Yunta, M, García-Aldea, Á, López de Toledo Soler, I, Bárez-López, S & Guadaño-Ferraz, A 2022, ' Deficient thyroid hormone transport to the brain leads to impairments in axonal caliber and oligodendroglial development ', Neurobiology of Disease, vol. 162, 105567, pp. 105567 . https://doi.org/10.1016/j.nbd.2021.105567
Valcárcel-Hernández, V, López-Espíndola, D, Guillén-Yunta, M, García-Aldea, Á, López de Toledo Soler, I, Bárez-López, S & Guadaño-Ferraz, A 2022, ' Deficient thyroid hormone transport to the brain leads to impairments in axonal caliber and oligodendroglial development ', Neurobiology of Disease, vol. 162, 105567, pp. 105567 . https://doi.org/10.1016/j.nbd.2021.105567
Mutations in the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to profound brain alterations, including myelination impairments, in humans. We aimed to further explore the pathophysiological mechanisms underlying the MCT8 defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0286027efd8230722231ccc0fef6a46
https://pubmed.ncbi.nlm.nih.gov/34838669
https://pubmed.ncbi.nlm.nih.gov/34838669
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Over the last decades, thyroid hormones (THs) signaling has been established as a key signaling cue for the proper maintenance of brain functions in adult mammals, including humans. One of the most fascinating roles of THs in the mature mammalian bra
Externí odkaz:
https://doaj.org/article/083d5417ef6c477e8500e50fdc7bc4c7
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S180-S181 (2023)
Externí odkaz:
https://doaj.org/article/0573610f1bd644829bd7da894f9701f2