Generation of two induced pluripotent stem cell (iPSC) lines from p.F508del Cystic Fibrosis patients

Autor: Aarne Fleischer, Iván M. Lorenzo, Esther Palomino, Trond Aasen, Fernando Gómez, Miguel Servera, Víctor J. Asensio, Víctor Gálvez, Juan Carlos Izpisúa-Belmonte, Daniel Bachiller

Publikováno v: Stem Cell Research, Vol 29, Iss , Pp 1-5 (2018)

Cystic Fibrosis (CF) is a monogenic, lethal disease caused by mutations in the cystic fibrosis transmembrane conductance (CFTR) gene. Here we report the production of CF-iPS cell lines from two different p.F508del homozygous female patients (Table 1)

Externí odkaz: https://doaj.org/article/7d340015e5a646fd956bf50ed2de16bc

Sodium colistimethate loaded lipid nanocarriers for the treatment of Pseudomonas aeruginosa infections associated with cystic fibrosis

Autor: María Moreno-Sastre, Miguel Viñas, José Luis Pedraz, A. Esquisabel, Daniel Bachiller, Víctor J. Asensio, Ángel Del Pozo, Marta Pastor, Eusebio Gainza, Eulàlia Sans

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

© 2014 Elsevier B.V. All rights reserved. Lung impairment is the most life-threatening factor for cystic fibrosis patients. Indeed, Pseudomonas aeruginosa is the main pathogen in the pulmonary infection of these patients. In this work, we developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb246978607b41868f8cfe5fdc81eb68
https://doi.org/10.1016/j.ijpharm.2014.10.048

Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase

Autor: Víctor J. Asensio, Laia Tolosa, Margalida Mir, Gabriel Olmos, Jerònia Lladó

Publikováno v: Journal of Neurochemistry. 105:1080-1090

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective death of motoneurons. Recently, vascular endothelial growth factor (VEGF) has been identified as a neurotrophic factor and has been implicated in the me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8a11e8ee542bd43bc4a7b0f229f8c2
https://doi.org/10.1111/j.1471-4159.2007.05206.x

Tumor necrosis factor alpha and interferon gamma cooperatively induce oxidative stress and motoneuron death in rat spinal cord embryonic explants

Autor: Laia Tolosa, Víctor J. Asensio, R.M. Soler, Margalida Mir, M. Gou-Fabregas, Gabriel Olmos, Jerònia Lladó

Publikováno v: Neuroscience. 162(4)

The accumulation of reactive microglia in the degenerating areas of amyotrophic lateral sclerosis (ALS) tissue is a key cellular event creating a chronic inflammatory environment that results in motoneuron death. We have developed a new culture syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7fa6237f4221f07648641a6df74b676
https://pubmed.ncbi.nlm.nih.gov/19477238

Generation of Replication-Proficient Influenza Virus NS1 Point Mutants with Interferon-Hyperinducer Phenotype

Autor: Y. Fernández, Víctor J. Asensio, Marian J. Killip, Richard E. Randall, José A. Bengoechea, Juan Ortín, Maite Pérez-Cidoncha

Publikováno v: Pérez-Cidoncha, M, Killip, M J, Asensio, V J, Fernández, Y, Bengoechea, J A, Randall, R E & Ortín, J 2014, ' Generation of replication-proficient influenza virus NS1 point mutants with interferon-hyperinducer phenotype ', PloS one, vol. 9, no. 6, e98668 . https://doi.org/10.1371/journal.pone.0098668
PLoS ONE
PLoS ONE, Vol 9, Iss 6, p e98668 (2014)

The NS1 protein of influenza A viruses is the dedicated viral interferon (IFN)-antagonist. Viruses lacking NS1 protein expression cannot multiply in normal cells but are viable in cells deficient in their ability to produce or respond to IFN. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99322a315ea5a2eff406bc1ae9f62fd
https://doi.org/10.1371/journal.pone.0098668