Topical Meloxicam Hydroxypropyl Guar Hydrogels Based on Low-Substituted Hydroxypropyl Cellulose Solid Dispersions

Autor: Zaid Dahma, Carlos Torrado-Salmerón, Covadonga Álvarez-Álvarez, Víctor Guarnizo-Herrero, Borja Martínez-Alonso, Guillermo Torrado, Santiago Torrado-Santiago, Paloma Marina de la Torre-Iglesias

Publikováno v: Gels, Vol 10, Iss 3, p 207 (2024)

Meloxicam (MX) is a poorly water-soluble drug with severe gastrointestinal side effects. Topical hydrogel of hydroxypropyl guar (HPG) was formulated using a solid dispersion (SD) of MX with hydroxypropyl cellulose (LHPC) as an alternative to oral adm

Externí odkaz: https://doaj.org/article/dfa8b2cdb3d74938847e77f04d9648cc

Improvement in the Oral Bioavailability and Efficacy of New Ezetimibe Formulations—Comparative Study of a Solid Dispersion and Different Micellar Systems

Autor: Carlos Torrado-Salmerón, Víctor Guarnizo-Herrero, Teresa Gallego-Arranz, Yvonne del Val-Sabugo, Guillermo Torrado, Javier Morales, Santiago Torrado-Santiago

Publikováno v: Pharmaceutics, Vol 12, Iss 7, p 617 (2020)

Ezetimibe (EZ) is a poorly water-soluble drug with low bioavailability. Strategies such as solid dispersions (SD) and micellar systems (MS) were developed to identify the most effective drug delivery formulations with the highest oral bioavailability

Externí odkaz: https://doaj.org/article/ea68b56d2fec4775a3cd0c176c0bd684

Solid dispersions of atorvastatin with Kolliphor RH40: Enhanced supersaturation and improvement in a hyperlipidemic rat model

Autor: Carlos Torrado-Salmerón, Víctor Guarnizo-Herrero, Guillermo Torrado, M. Ángeles Peña, Santiago Torrado-Santiago, Paloma Marina de la Torre-Iglesias

Publikováno v: International Journal of Pharmaceutics. 631:122520

Atorvastatin is a potent lipid-lowering drug with poor solubility and high presystemic clearance that limits its therapeutic efficacy. The aim of this study was to develop solid dispersions and micellar systems to obtain fast-dissolving atorvastatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e44e2f57fa4c9bc8611216d63de13f
https://doi.org/10.1016/j.ijpharm.2022.122520

Improvement of the pharmacokinetic/pharmacodynamic relationship in the treatment of invasive aspergillosis with voriconazole. Reduced drug toxicity through novel rapid release formulations

Autor: Carlos Torrado-Salmerón, Javier Capilla, Alba Pérez-Cantero, Víctor Guarnizo-Herrero, Teresa Gallego-Arranz, Santiago Torrado-Durán

Publikováno v: Colloids and Surfaces B: Biointerfaces. 193:111119

Voriconazole (VCZ) is currently the first-line treatment for invasive aspergillosis, although the doses are limited by its poor solubility and high hepatic toxicity. The aim of this study was to develop a solid self-dispersing micellar system of VCZ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78655a9504c987b0cb73974e468b9290
https://doi.org/10.1016/j.colsurfb.2020.111119

Carminic Acid Linked to Silica Nanoparticles as Pigment/Antioxidant Bifunctional Excipient for Pharmaceutical Emulsions

Autor: Germán Günther, Javier O. Morales, Santi Nonell, Francisco Arriagada, María Angélica Larraín, Catalina Ugarte, Víctor Guarnizo-Herrero

Publikováno v: Pharmaceutics
Volume 12
Issue 4
E-Prints Complutense. Archivo Institucional de la UCM
instname
RECERCAT (Dipòsit de la Recerca de Catalunya)
Pharmaceutics, Vol 12, Iss 376, p 376 (2020)

The incorporation of pigments and natural polyphenols into inorganic matrices, resulting in a hybrid material that improves the resistance and chemical stability of the pigments and the antioxidant capacity of the materials, has been of great interes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1d05789cd291a4752b70c57ecb3980
https://doi.org/10.3390/pharmaceutics12040376