Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Víctor Farré Alins"'
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Akademický článek
Randomized controlled trial on healthy volunteers of pharmacokinetic and antimicrobial activity of a novel hydrogel-containing chlorhexidine dressing to prevent catheter-related bloodstream infection
Autor: Emili Masferrer, Laura Riera-Rodríguez, Víctor Farré-Alins, Sandra Vilà de Muga, Francisco-Javier Arroyo-Muñoz, María-Dolores González-Caro
Publikováno v: Frontiers in Medicine, Vol 10 (2024)
IntroductionCatheter-related blood stream infection (CRBSI) is one of the most relevant complications associated to the use of intravascular catheters. In this context, chlorhexidine gluconate (CHG) releasing dressings have been developed to reduce t
Externí odkaz: https://doaj.org/article/281c0316cbac40dd93a98efab98c0e1b
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2
Akademický článek
Redox Regulation of Microglial Inflammatory Response: Fine Control of NLRP3 Inflammasome through Nrf2 and NOX4
Autor: Alejandra Palomino-Antolín, Céline Decouty-Pérez, Víctor Farré-Alins, Paloma Narros-Fernández, Ana Belen Lopez-Rodriguez, María Álvarez-Rubal, Inés Valencia, Francisco López-Muñoz, Eva Ramos, Antonio Cuadrado, Ana I. Casas, Alejandro Romero, Javier Egea
Publikováno v: Antioxidants, Vol 12, Iss 9, p 1729 (2023)
The role of inflammation and immunity in the pathomechanism of neurodegenerative diseases has become increasingly relevant within the past few years. In this context, the NOD-like receptor protein 3 (NLRP3) inflammasome plays a crucial role in the ac
Externí odkaz: https://doaj.org/article/552434a0330b4ac5ab6087e7cbc3bf4f
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4
Akademický článek
Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux
Autor: Víctor Farré-Alins, Paloma Narros-Fernández, Alejandra Palomino-Antolín, Céline Decouty-Pérez, Ana Belen Lopez-Rodriguez, Esther Parada, Alicia Muñoz-Montero, Vanessa Gómez-Rangel, Francisco López-Muñoz, Eva Ramos, Águeda González-Rodríguez, Luis Gandía, Alejandro Romero, Javier Egea
Publikováno v: Antioxidants, Vol 9, Iss 12, p 1299 (2020)
Microglia controls the immune system response in the brain. Specifically, the activation and dysregulation of the NLRP3 inflammasome is responsible for the initiation of the inflammatory process through IL-1β and IL-18 release. In this work, we have
Externí odkaz: https://doaj.org/article/7f5db3adb4c44b268e7337f0de0bc644
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5
Synthesis and Pharmacological Evaluation of New
Autor: Paloma, Narros-Fernández, Mourad, Chioua, Sonia A, Petcu, Daniel, Diez-Iriepa, Laura, Cerrada-Gálvez, Céline, Decouty-Pérez, Alejandra, Palomino-Antolín, Eva, Ramos, Víctor, Farré-Alins, Ana Belén, López-Rodríguez, Alejandro, Romero, José, Marco-Contelles, Javier, Egea
Publikováno v: Journal of medicinal chemistry. 65(8)
NLRP3 is involved in the pathophysiology of several inflammatory diseases. Therefore, there is high current interest in the clinical development of new NLRP3 inflammasome small inhibitors to treat these diseases. Novel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef605395c7cbc7202a1ebe2be9921030
https://pubmed.ncbi.nlm.nih.gov/35403430
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6
Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout
Autor: Paloma Narros-Fernández, Mourad Chioua, Sonia A. Petcu, Daniel Diez-Iriepa, Laura Cerrada-Gálvez, Céline Decouty-Pérez, Alejandra Palomino-Antolín, Eva Ramos, Víctor Farré-Alins, Ana Belén López-Rodríguez, Alejandro Romero, José Marco-Contelles, Javier Egea
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
NLRP3 is involved in the pathophysiology of several inflammatory diseases. Therefore, there is high current interest in the clinical development of new NLRP3 inflammasome small inhibitors to treat these diseases. Novel N-sulfonylureas were obtained b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48f3a4bb146380d5691972d2510589b
http://hdl.handle.net/10261/280309
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7
Time-dependent dual effect of NLRP3 inflammasome in brain ischaemia
Autor: Javier Sevilla-Montero, Luis Monge, Ana I. Casas, Javier Egea, Paloma Narros-Fernández, Nuria Fernández, Ana Belen Lopez-Rodriguez, Maria J. Calzada, Celine Decouty-Pérez, Alejandra Palomino-Antolín, Víctor Farré-Alins
Publikováno v: British Journal of Pharmacology, 179(7), 1395-1410. Wiley
BACKGROUND Post-ischemic inflammation contributes to worsening of ischemic brain injury and in this process, the inflammasomes play a key role. Inflammasomes are cytosolic multiprotein complexes which upon assembly activate the maturation and secreti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306b121cf1680025e27caf8bcd08165c
https://pubmed.ncbi.nlm.nih.gov/34773639
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8
Early toll-like receptor 4 blockade reduces ROS and inflammation triggered by microglial pro-inflammatory phenotype in rodent and human brain ischaemia models
Autor: Paloma Narros-Fernández, Melania Guerrero-Hue, Víctor Farré-Alins, José M. Roda, Vanessa Gómez-Rangel, Juan Antonio Moreno, Juliana M. Rosa, Alfonso Rubio-Navarro, Ana I. Casas, Alejandra Palomino-Antolín, Esther Parada, Borja J. Hernández-García, Javier Egea
Publikováno v: British Journal of Pharmacology, 176(15), 2764-2779. Wiley
Br J Pharmacol
Background and purpose Ischaemic stroke is a leading cause of death, disability, and a high unmet medical need. Post-reperfusion inflammation and an up-regulation of toll-like receptor 4 (TLR4), an upstream sensor of innate immunity, are associated w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15f7c9f09c646b6688d97e7cd3b63fb
https://doi.org/10.1111/bph.14703
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9
Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis‐mediated cell death
Autor: Alejandra Palomino-Antolín, Pablo Cannata, Diego Martin-Sanchez, Carmen Herencia, Javier Egea, Alberto Ortiz, Ana Belen Sanz, Jesús Egido, Víctor Farré-Alins, Manuel Praga, Cristina Vázquez-Carballo, Juan Antonio Moreno, Melania Guerrero-Hue, Alfonso Rubio-Navarro, Cristina García-Caballero
Publikováno v: The FASEB Journal. 33:8961-8975
Acute kidney injury is a common complication of rhabdomyolysis. A better understanding of this syndrome may be useful to identify novel therapeutic targets because there is no specific treatment so far. Ferroptosis is an iron-dependent form of regula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dcc70bcfd382a2f596af0d256e68de
https://doi.org/10.1096/fj.201900077r
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