Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Véronique Thybaud"'
Autor:
Véronique Thybaud, Kerry L. Dearfield, Roland Froetschl, Jennifer C. Sasaki, Mirjam Luijten, George E. Johnson, John Nicolette, Michelle R. Embry, Laura Custer, Gladys Ouedraogo, Raja S. Settivari
Publikováno v:
Environmental and Molecular Mutagenesis. 62:512-525
We present a hypothetical case study to examine the use of a next-generation framework developed by the Genetic Toxicology Technical Committee of the Health and Environmental Sciences Institute for assessing the potential risk of genetic damage from
Autor:
Sheroy Minocherhomji, George E. Johnson, Véronique Thybaud, B. Bhaskar Gollapudi, Krista L. Dobo, James Harvey, Julia Kenny, Andreas Zeller, Michelle O. Kenyon, Ryan P Wheeldon, John Nicolette, Anthony M. Lynch
Publikováno v:
Environmental and Molecular Mutagenesis. 62:293-305
A genotoxic carcinogen, N-nitrosodimethylamine (NDMA), was detected as a synthesis impurity in some valsartan drugs in 2018, and other N-nitrosamines, such as N-nitrosodiethylamine (NDEA), were later detected in other sartan products. N-nitrosamines
Autor:
Steven M. Bryce, Laura Custer, Kerry L. Dearfield, Carole L. Yauk, Giel Hendriks, Ashley Allemang, Sheila M. Galloway, Maik Schuler, Stefan Pfuhler, Patricia A Escobar, Azeddine Elhajouji, Gladys Ouedraogo, Albert J. Fornace, Heng-Hong Li, Jennifer C. Sasaki, Daniel J Roberts, Yasmin Dietz, Ulrike Hemmann, Jan van Benthem, Véronique Thybaud, Roland Froetschl, Lauren Peel, Mirjam Luijten
In May 2017, the Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee hosted a workshop to discuss whether mode of action (MOA) investigation is enhanced through the application of the adverse outcome pathway (AOP) fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94120698a05b8acf2acfae209b20a2b1
http://hdl.handle.net/10029/623463
http://hdl.handle.net/10029/623463
Autor:
Véronique Thybaud, Jos C. S. Kleinjans, Jason H. Bielas, Paul D. White, Francesco Marchetti, Ann T. Doherty, Carole L. Yauk, Yukari Totsuka, Masamitsu Honma, Stephen D. Dertinger, Maik Schuler
Publikováno v:
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 847:403022. Elsevier
We live in an era of 'big data', where the volume, velocity, and variety of the data being generated is increasingly influencing the way toxicological sciences are practiced. With this in mind, a workgroup was formed for the 2017 International Worksh
Autor:
Michelle O. Kenyon, Melisa Masuda-Herrera, Angela White, Véronique Thybaud, John Nicolette, Robert A. Jolly, Susanne Glowienke, Sheila M. Galloway, P. Parris, P. Heard, Elizabeth A. Martin, Esther Vock, Krista L. Dobo, Laura Custer, James Harvey, W. Ku, Joel P. Bercu, Andrew Teasdale
Publikováno v:
Regulatory Toxicology and Pharmacology. 94:172-182
This paper provides compound-specific toxicology limits for 20 widely used synthetic reagents and common by-products that are potential impurities in drug substances. In addition, a 15 μg/day class-specific limit was developed for monofunctional alk
Autor:
Richard A. Spellman, David Kirkland, Véronique Thybaud, Melanie Guérard, Stephen D. Dertinger, Steven M. Bryce, Andreas Zeller, Jeffrey C. Bemis, Maik Schuler, Sabrina Wilde, Elisabeth Lorge, Andreas Sutter, Ulrike Hemmann, Nina Queisser, Pekka T. Heikkinen, Derek T. Bernacki, Maria Engel
Publikováno v:
Environmental and Molecular Mutagenesis. 58:146-161
We previously described a multiplexed in vitro genotoxicity assay based on flow cytometric analysis of detergent-liberated nuclei that are simultaneously stained with propidium iodide and labeled with fluorescent antibodies against p53, γH2AX, and p
Autor:
Francesco Marchetti, Elisabeth Lorge, Dan D. Levy, Véronique Thybaud, Jan van Benthem, George R. Douglas, Rita Schoeny, Martha M. Moore
Publikováno v:
Environmental and Molecular Mutagenesis. 58:284-295
The Organization for Economic Cooperation and Development (OECD) recently revised the test guidelines (TGs) for genetic toxicology. This article describes the main issues addressed during the revision process, and the new and consistent recommendatio
Autor:
Jennifer Y. Tanir, Elisabeth Lorge, Mick D. Fellows, Véronique Thybaud, Masamitsu Honma, M.R. O'Donovan, B. Bhaskar Gollapudi, Marilyn J. Aardema, A. Kohara, Michael J. Armstrong, Sheila M. Galloway, Julie Clements, Martha M. Moore
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 809:1-15
Good cell culture practice and characterization of the cell lines used are of critical importance in in vitro genotoxicity testing. The objective of this initiative was to make continuously available stocks of the characterized isolates of the most f
Autor:
Véronique Thybaud, Christopher S Farabaugh, Frank Le Curieux, John Nicolette, Javed A. Bhalli, Melanie Guérard, Marilyn J. Aardema, George R. Douglas, David P. Lovell, Leon F. Stankowski, George E. Johnson, Andrew Williams, Mirjam Luijten, Sandy Weiner, Kristine L. Witt, Carol Beevers, Jasmin Lott, Francesco Marchetti, Patricia A. Escobar, Alexandra S. Long, Daniel J Roberts, Robert R. Young, David Kirkland, Rohan Kulkarni, Stefan Pfuhler, Matthew J. LeBaron, Dan D. Levy
A database of 91 chemicals with published data from both transgenic rodent mutation (TGR) and rodent comet assays has been compiled. The objective was to compare the sensitivity of the two assays for detecting genotoxicity. Critical aspects of study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5685a1dd3e8efa3d80cab9943695dcf
https://openaccess.sgul.ac.uk/id/eprint/110683/1/1-s2.0-S1383571818304169-main.pdf
https://openaccess.sgul.ac.uk/id/eprint/110683/1/1-s2.0-S1383571818304169-main.pdf
Autor:
Emiel Rorije, David Kirkland, Jennifer Y. Tanir, Kerry L. Dearfield, Mirjam Luijten, Albert P. Li, Rosalie K. Elespuru, Errol Zeiger, Carole L. Yauk, Véronique Thybaud, Lynn H. Pottenger, Francesco Marchetti, George R. Douglas, Jeffrey C. Bemis, Jan van Benthem, George E. Johnson, B. Bhaskar Gollapudi, Matthew J. LeBaron, R. Daniel Benz
Publikováno v:
Environmental and Molecular Mutagenesis. 58:264-283
For several decades, regulatory testing schemes for genetic damage have been standardized where the tests being utilized examined mutations and structural and numerical chromosomal damage. This has served the genetic toxicity community well when most