Zobrazeno 1 - 10 of 61 pro vyhledávání: '"Véronique Roig"'
1
Akademický článek
Carnitine is a pharmacological allosteric chaperone of the human lysosomal α-glucosidase
Autor: Roberta Iacono, Nadia Minopoli, Maria Carmina Ferrara, Antonietta Tarallo, Carla Damiano, Caterina Porto, Sandra Strollo, Véronique Roig-Zamboni, Gianfranco Peluso, Gerlind Sulzenbacher, Beatrice Cobucci-Ponzano, Giancarlo Parenti, Marco Moracci
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 2068-2079 (2021)
Pompe disease is an inherited metabolic disorder due to the deficiency of the lysosomal acid α-glucosidase (GAA). The only approved treatment is enzyme replacement therapy with the recombinant enzyme (rhGAA). Further approaches like pharmacological
Externí odkaz: https://doaj.org/article/7db4e2f4002a4340b38daa8d1bb2c018
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2
Akademický článek
Structure of human lysosomal acid α-glucosidase–a guide for the treatment of Pompe disease
Autor: Véronique Roig-Zamboni, Beatrice Cobucci-Ponzano, Roberta Iacono, Maria Carmina Ferrara, Stanley Germany, Yves Bourne, Giancarlo Parenti, Marco Moracci, Gerlind Sulzenbacher
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Pompe disease is caused by mutations in lysosomal acid α-glucosidase (GAA) and patients are being treated with recombinant human α-glucosidase (rhGAA). Here the authors present the crystal structures of rhGAA and its complexes with inhibitors and a
Externí odkaz: https://doaj.org/article/1092edf30ccd4d65964b3a4b8b5fdd66
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3
Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis
Autor: Sarah Barelier, Romain Avellan, Giri Raj Gnawali, Patrick Fourquet, Véronique Roig‐Zamboni, Isabelle Poncin, Vanessa Point, Yves Bourne, Stéphane Audebert, Luc Camoin, Christopher D. Spilling, Stéphane Canaan, Jean‐François Cavalier, Gerlind Sulzenbacher
Publikováno v: FEBS Journal
FEBS Journal, 2022, ⟨10.1111/febs.16645⟩
International audience; A hallmark of Mycobacterium tuberculosis (M. tb), the etiologic agent of tuberculosis, is its ability to metabolize host-derived lipids. However, the enzymes and mechanisms underlying such metabolism are still largely unknown.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fcf3323979e866a4afd2a38d8e5be5
https://hal-amu.archives-ouvertes.fr/hal-03799115/document
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4
Carnitine is a pharmacological allosteric chaperone of the human lysosomal α-glucosidase
Autor: Sandra Strollo, Gianfranco Peluso, Caterina Porto, Gerlind Sulzenbacher, Carla Damiano, Nadia Minopoli, Antonietta Tarallo, Marco Moracci, Véronique Roig-Zamboni, Giancarlo Parenti, Beatrice Cobucci-Ponzano, Maria Carmina Ferrara, Roberta Iacono
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of enzyme inhibition and medicinal chemistry
36 (2021): 2068–2079. doi:10.1080/14756366.2021.1975694
info:cnr-pdr/source/autori:Iacono, Roberta; Minopoli, Nadia; Ferrara, Maria Carmina; Tarallo, Antonietta; Damiano, Carla; Porto, Caterina; Strollo, Sandra; Roig-Zamboni, Veronique; Peluso, Gianfranco; Sulzenbacher, Gerlind; Cobucci-Ponzano, Beatrice; Parenti, Giancarlo; Moracci, Marco/titolo:Carnitine is a pharmacological allosteric chaperone of the human lysosomal alpha-glucosidase/doi:10.1080%2F14756366.2021.1975694/rivista:Journal of enzyme inhibition and medicinal chemistry (Print)/anno:2021/pagina_da:2068/pagina_a:2079/intervallo_pagine:2068–2079/volume:36
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2021, 36 (1), pp.2068-2079. ⟨10.1080/14756366.2021.1975694⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 2068-2079 (2021)
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36 (1), pp.2068-2079. ⟨10.1080/14756366.2021.1975694⟩
International audience; Pompe disease is an inherited metabolic disorder due to the deficiency of the lysosomal acid α-glucosidase (GAA). The only approved treatment is enzyme replacement therapy with the recombinant enzyme (rhGAA). Further approach
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cccde6b8d490ed35096955d6bfb78ef
http://europepmc.org/articles/PMC8477953
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6
Flash-Boiling Characterization During Ingress of Coolant Event for Dust Issue in ITER
Autor: Benjamin Blaisot, Emmanuel Porcheron, Olivier Praud, Véronique Roig
Publikováno v: Journal of Nuclear Engineering and Radiation Science. 8
Dust resuspension inside the vacuum vessel (VV) is one of the safety issues of the fusion reactor ITER. Plasma interaction with the plasma facing components (PFC) leads to their erosion, generating dust. One of the accident scenarios leading to dust
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd8f96eb0745ac5c18dcd3fc6cfa9cf6
https://doi.org/10.1115/1.4053828
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7
Molecular basis for substrate recognition and septum cleavage by AtlA, the major N-acetylglucosaminidase of Enterococcus faecalis
Autor: Véronique Roig-Zamboni, Sarah Barelier, Robert Dixon, Nicola F. Galley, Amani Ghanem, Quoc Phong Nguyen, Héloize Cahuzac, Bartłomiej Salamaga, Peter J. Davis, Yves Bourne, Stéphane Mesnage, Florence Vincent
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2022, 298 (5), pp.101915. ⟨10.1016/j.jbc.2022.101915⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2022, pp.101915. ⟨10.1016/j.jbc.2022.101915⟩
International audience; The cleavage of septal peptidoglycan at the end of cell division facilitates the separation of the two daughter cells. The hydrolases involved in this process (called autolysins) are potentially lethal enzymes that can cause c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a934766a1cda4b1815cc1713f48dbdf7
https://pubmed.ncbi.nlm.nih.gov/35398351
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8
Kinematics of a bubble freely rising in a thin-gap cell with additional in-plane confinement
Autor: Lucas Pavlov, Véronique Roig, M. Cachile, M. Verónica D'Angelo, Patricia Ern
Publikováno v: Physical Review Fluids
Physical Review Fluids, American Physical Society, 2021, 6 (9), pp.093605. ⟨10.1103/PhysRevFluids.6.093605⟩
International audience; We analyze the behavior of air bubbles freely rising at high Reynolds numbers in a planar thin-gap cell filled with distilled water. The gap thickness of the cell is fixed to h≃2.8 mm (or h≃1 mm in additional experiments)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a093d0dafe2ef659966d1ec68d75e8
https://doi.org/10.1103/physrevfluids.6.093605
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9
Exploration by Shake-the-Box technique of the 3D perturbation induced by a bubble rising in a thin-gap cell
Autor: Sébastien Cazin, Lucas Pavlov, Véronique Roig, Patricia Ern
Publikováno v: Experiments in Fluids
Experiments in Fluids, Springer Verlag (Germany), 2021, 62, pp.22. ⟨10.1007/s00348-020-03117-z⟩
International audience; From Lagrangian measurements using the Shake-the-Box technique (Schanz et al. in Exp Fluids 57(5):70, 2016) we investigate the velocity field about a single bubble rising in a thin-gap cell and we discuss it in an Eulerian fra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c512a16b4d1a360a2907cc88692f13
https://oatao.univ-toulouse.fr/28118/
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10
First insights into the structural features of Ebola virus methyltransferase activities
Autor: Bruno Canard, Aline Desmyter, Jean-Jacques Vasseur, Coralie Valle, Françoise Debart, Bruno Coutard, Baptiste Martin, Véronique Roig-Zamboni, Etienne Decroly, François Ferron
Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2021, 49 (3), pp.1737-1748. ⟨10.1093/nar/gkaa1276⟩
Nucleic Acids Research, Oxford University Press, 2021, 49 (3), pp.1737-1748. ⟨10.1093/nar/gkaa1276⟩
The Ebola virus is a deadly human pathogen responsible for several outbreaks in Africa. Its genome encodes the ‘large’ L protein, an essential enzyme that has polymerase, capping and methyltransferase activities. The methyltransferase activity le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f533a9ac97d6f0a99553d8c5faf4ee22
https://hal.science/hal-03334409/document
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