Výsledky vyhledávání - "Véronique Pons"

Akademický článek

Platelet P2Y1 receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment

Autor: Agnès Ribes, Cédric Garcia, Marie-Pierre Gratacap, Evi Kostenis, Laurent O. Martinez, Bernard Payrastre, Jean-Michel Sénard, Céline Galés, Véronique Pons

Publikováno v: BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)

Abstract Background Purinergic P2Y1 and P2Y12 receptors (P2Y1-R and P2Y12-R) are G protein-coupled receptors (GPCR) activated by adenosine diphosphate (ADP) to mediate platelet activation, thereby playing a pivotal role in hemostasis and thrombosis.

Externí odkaz: https://doaj.org/article/6ae6386caf484ccca6c2de46387787d6

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Akademický článek

Atomic force microscopy-single-molecule force spectroscopy unveils GPCR cell surface architecture

Autor: Etienne Dague, Véronique Pons, Alexandre Roland, Jean-Marc Azaïs, Silvia Arcucci, Véronique Lachaize, Samuel Velmont, Emmanuelle Trevisiol, Du N’Guyen, Jean-Michel Sénard, Céline Galés

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)

Atomic force microscopy-based single molecule force spectroscopy reveals the unfolding of G-protein coupled receptors on the surface of living mammalian cells.

Externí odkaz: https://doaj.org/article/67f6e8d7ba7549038bda4fd59c9c2b69

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Akademický článek

Serum IF1 concentration is independently associated to HDL levels and to coronary heart disease: the GENES study

Autor: Annelise Genoux, Jean-Bernard Ruidavets, Jean Ferrières, Guillaume Combes, Laeticia Lichtenstein, Véronique Pons, Muriel Laffargue, Dorota Taraszkiewicz, Didier Carrié, Meyer Elbaz, Bertrand Perret, Laurent O. Martinez

Publikováno v: Journal of Lipid Research, Vol 54, Iss 9, Pp 2550-2558 (2013)

HDL is strongly inversely related to cardiovascular risk. Hepatic HDL uptake is controlled by ecto-F1-ATPase activity, and potentially inhibited by mitochondrial inhibitor factor 1 (IF1). We recently found that IF1 is present in serum and correlates

Externí odkaz: https://doaj.org/article/21d0863dacdb49789eae7e19157d3668

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Akademický článek

SNX12 role in endosome membrane transport.

Autor: Véronique Pons, Cansel Ustunel, Corinne Rolland, Eleonora Torti, Robert G Parton, Jean Gruenberg

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38949 (2012)

In this paper, we investigated the role of sorting nexin 12 (SNX12) in the endocytic pathway. SNX12 is a member of the PX domain-containing sorting nexin family and shares high homology with SNX3, which plays a central role in the formation of intral

Externí odkaz: https://doaj.org/article/301ffaf390874d29a5855d790d1c041a

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Akademický článek

Mitochondrial inhibitory factor 1 (IF1) is present in human serum and is positively correlated with HDL-cholesterol.

Autor: Annelise Genoux, Véronique Pons, Claudia Radojkovic, Florence Roux-Dalvai, Guillaume Combes, Corinne Rolland, Nicole Malet, Bernard Monsarrat, Frédéric Lopez, Jean-Bernard Ruidavets, Bertrand Perret, Laurent O Martinez

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e23949 (2011)

BackgroundMitochondrial ATP synthase is expressed as a plasma membrane receptor for apolipoprotein A-I (apoA-I), the major protein component in High Density Lipoproteins (HDL). On hepatocytes, apoA-I binds to cell surface ATP synthase (namely ecto-F(

Externí odkaz: https://doaj.org/article/fa20b709c73f4af6ae71250b606b4ea9

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Akademický článek

Role of SNX16 in the dynamics of tubulo-cisternal membrane domains of late endosomes.

Autor: Ben Brankatschk, Véronique Pons, Robert G Parton, Jean Gruenberg

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e21771 (2011)

In this paper, we report that the PX domain-containing protein SNX16, a member of the sorting nexin family, is associated with late endosome membranes. We find that SNX16 is selectively enriched on tubulo-cisternal elements of this membrane system, w

Externí odkaz: https://doaj.org/article/787a63afde994bc78ab1565be25c6c99

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Akademický článek

Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies.

Autor: Véronique Pons, Pierre-Philippe Luyet, Etienne Morel, Laurence Abrami, F Gisou van der Goot, Robert G Parton, Jean Gruenberg

Publikováno v: PLoS Biology, Vol 6, Iss 9, p e214 (2008)

After internalization, ubiquitinated signaling receptors are delivered to early endosomes. There, they are sorted and incorporated into the intralumenal invaginations of nascent multivesicular bodies, which function as transport intermediates to late

Externí odkaz: https://doaj.org/article/069374da306a43c8b6d9ee4d24b23dcc

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Inverse agonist efficacy of selatogrel blunts constitutive P2Y12 receptor signaling by inducing the inactive receptor conformation

Autor: Véronique Pons, Cédric Garcia, Naomi Tidten-Luksch, Aengus Mac Sweeney, Eva Caroff, Céline Galés, Markus A. Riederer

Publikováno v: Biochemical pharmacology. 206

Selatogrel is a potent inhibitor of adenosine diphosphate (ADP) binding to the P2Y12 receptor, preventing platelet activation. We have previously shown that the P2Y12 receptor constitutively activates Gi- and Go-protein-mediated signaling in human pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10834c4b2d30ebb1004f17c4db090b6
https://pubmed.ncbi.nlm.nih.gov/36306820

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Atomic force microscopy-single-molecule force spectroscopy unveils GPCR cell surface architecture

Autor: Etienne Dague, Véronique Pons, Alexandre Roland, Jean-Marc Azaïs, Silvia Arcucci, Véronique Lachaize, Samuel Velmont, Emmanuelle Trevisiol, Du N’Guyen, Jean-Michel Sénard, Céline Galés

Publikováno v: Communications Biology
Communications Biology, 2022, 5 (1), ⟨10.1038/s42003-022-03162-w⟩

International audience; G protein-coupled receptors (GPCRs) form the largest family of cell surface receptors. Despite considerable insights into their pharmacology, the GPCR architecture at the cell surface still remains largely unexplored. Herein,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcf7a0b481215f77f5d24cd784f8efc
https://pubmed.ncbi.nlm.nih.gov/35273337

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Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ectophospholipase C acting as an endocannabinoid signaling switch

Autor: Fabienne, Briand-Mésange, Véronique, Pons, Sophie, Allart, Julien, Masquelier, Gaëtan, Chicanne, Nicolas, Beton, Bernard, Payrastre, Giulio G, Muccioli, Jérôme, Ausseil, Jean-Luc, Davignon, Jean-Pierre, Salles, Hugues, Chap

Publikováno v: The Journal of biological chemistry, Vol. 295, no.46, p. 15767-15781 (2020)
Journal of Biological Chemistry
Journal of Biological Chemistry, 2020, 295 (46), pp.15767-15781. ⟨10.1074/jbc.RA120.015278⟩
J Biol Chem

International audience; Endocannabinoid signaling plays a regulatory role in various (neuro)biological functions. 2-arachidonoylglycerol (2-AG) is the most abundant endocannabinoid, and although its canonical biosynthetic pathway involving phosphoino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c94a7ed71f3f74510004f3f126916881
https://hdl.handle.net/2078.1/245676

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