Toward a Better Understanding of the Basis of the Molecular Mimicry of Polysaccharide Antigens by Peptides

Autor: Véronique Marcel-Peyre, Anne Imberty, Antoine Fortuné, Armelle Phalipon, Laurence A. Mulard, Catherine Simenel, Muriel Delepierre, Marie-Jeanne Clément

Publikováno v: Journal of Biological Chemistry. 281:2317-2332

Protein conjugates of oligosaccharides or peptides that mimic complex bacterial polysaccharide antigens represent alternatives to the classical polysaccharide-based conjugate vaccines developed so far. Hence, a better understanding of the molecular b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb41f2c860a5f8dc65f7302d79b875af
https://doi.org/10.1074/jbc.m510172200

A putative kinetic model for substrate metabolisation byDrosophilaacetylcholinesterase

Autor: Patrick Masson, Jure Stojan, Sandino Estrada-Mondaca, Alain Klaebe, Véronique Marcel, Didier Fournier

Publikováno v: FEBS Letters. 440:85-88

Insect acetylcholinesterase, an enzyme whose catalytic site is located at the bottom of a gorge, can metabolise its substrate in a wide range of concentrations (from 1 μM to 200 mM) since it is activated at low substrate concentrations. It also pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4148d3b7a382fb09b99742ac13106fc9
https://doi.org/10.1016/s0014-5793(98)01434-3

Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine

Autor: Brigitte Vulliez-Le Normand, Laurence A. Mulard, Karen L. Wright, Frédéric Bélot, Philippe J. Sansonetti, Corina Costachel, Cyrille Grandjean, Véronique Marcel-Peyre, Myriam Tanguy, Catherine Guerreiro, Farida Nato, Audrey Thuizat, Armelle Phalipon

Publikováno v: Journal of Immunology
Journal of Immunology, 2006, 176 (3), pp.1686-94. ⟨10.4049/jimmunol.176.3.1686⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2006, 176 (3), pp.1686-94. ⟨10.4049/jimmunol.176.3.1686⟩

Protection against reinfection with noncapsulated Gram-negative bacteria, such as Shigella, an enteroinvasive bacterium responsible for bacillary dysentery, is mainly achieved by Abs specific for the O-Ag, the polysaccharide part of the LPS, the majo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff9cca3cae21caea9d725d88a7bb775
https://hal-pasteur.archives-ouvertes.fr/pasteur-00166117/file/1686.pdf

Effect of tetramethylammonium, choline and edrophonium on insect acetylcholinesterase: test of a kinetic model

Autor: Didier Fournier, Jure Stojan, Véronique Marcel

Publikováno v: Chemico-biological interactions.

Cholinesterases display a non-Michaelian behaviour with respect to substrate concentration. With the insect enzyme, there is an activation at low substrate concentrations and an inhibition at high concentrations. Previous studies allow us to propose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4da45b826b6ffd14e2a98b639c95d6
https://pubmed.ncbi.nlm.nih.gov/10421447

Two invertebrate acetylcholinesterases show activation followed by inhibition with substrate concentration

Autor: Véronique Marcel, Christophe Pertuy, Patrick Masson, Didier Fournier, Laurent Gagnoux Palacios

Publikováno v: Scopus-Elsevier
ResearcherID

In vertebrates there are two cholinesterases, with differences in catalytic behaviour with respect to substrate concentration: butyrylcholinesterase displays an increased activity at low substrate concentrations, whereas acetylcholinesterase displays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed738116d1df01236de4153c66b50a06
https://europepmc.org/articles/PMC1219048/