Výsledky vyhledávání - "Véronique Lenoir"

Akademický článek

The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism

Autor: Emmanuel Benichou, Bolaji Seffou, Selin Topçu, Ophélie Renoult, Véronique Lenoir, Julien Planchais, Caroline Bonner, Catherine Postic, Carina Prip-Buus, Claire Pecqueur, Sandra Guilmeau, Marie-Clotilde Alves-Guerra, Renaud Dentin

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)

Abstract Cancer cells integrate multiple biosynthetic demands to drive unrestricted proliferation. How these cellular processes crosstalk to fuel cancer cell growth is still not fully understood. Here, we uncover the mechanisms by which the transcrip

Externí odkaz: https://doaj.org/article/1b6f7d6ad8174e00a2a1cd198b678263

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Akademický článek

Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes

Autor: Jérémie Gautheron, Lara Lima, Baris Akinci, Jamila Zammouri, Martine Auclair, Sema Kalkan Ucar, Samim Ozen, Canan Altay, Bridget E. Bax, Ivan Nemazanyy, Véronique Lenoir, Carina Prip-Buus, Cécile Acquaviva-Bourdain, Olivier Lascols, Bruno Fève, Corinne Vigouroux, Esther Noel, Isabelle Jéru

Publikováno v: BMC Medicine, Vol 20, Iss 1, Pp 1-21 (2022)

Abstract Background Thymidine phosphorylase (TP), encoded by the TYMP gene, is a cytosolic enzyme essential for the nucleotide salvage pathway. TP catalyzes the phosphorylation of the deoxyribonucleosides, thymidine and 2′-deoxyuridine, to thymine

Externí odkaz: https://doaj.org/article/f23ef112e8e2444f9f3eb4e619a1fccc

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Akademický článek

UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling

Autor: Tiphaine Sancerni, Ophélie Renoult, Angèle Luby, Cédric Caradeuc, Véronique Lenoir, Mikael Croyal, Céline Ransy, Esther Aguilar, Catherine Postic, Gildas Bertho, Renaud Dentin, Carina Prip-Buus, Claire Pecqueur, Marie-Clotilde Alves-Guerra

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from early T cell progenitors. Since relapsed T-ALL is associated with a poor prognosis improving initial treatment of patients is essential to avoid resistan

Externí odkaz: https://doaj.org/article/d4f247c17f74436cb37d1d771bc56fff

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Akademický článek

UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses

Autor: Esther Aguilar, Pauline Esteves, Tiphaine Sancerni, Véronique Lenoir, Thomas Aparicio, Frédéric Bouillaud, Renaud Dentin, Carina Prip-Buus, Daniel Ricquier, Claire Pecqueur, Sandra Guilmeau, Marie-Clotilde Alves-Guerra

Publikováno v: Cell Reports, Vol 28, Iss 9, Pp 2306-2316.e5 (2019)

Summary: Colorectal cancer (CRC) is associated with metabolic and redox perturbation. The mitochondrial transporter uncoupling protein 2 (UCP2) controls cell proliferation in vitro through the modulation of cellular metabolism, but the underlying mec

Externí odkaz: https://doaj.org/article/018acc7a8f454f4fb747a5c73a8e0a30

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Data Supplement from Mitochondrial Retrograde Signaling Mediated by UCP2 Inhibits Cancer Cell Proliferation and Tumorigenesis

Autor: Marie-Clotilde Alves-Guerra, Daniel Ricquier, Carina Prip-Buus, Anne Lombès, Anne-Laure Bulteau, Frédéric Bouillaud, Véronique Lenoir, Catherine Esnous, Céline Ransy, Claire Pecqueur, Pauline Esteves

Figure S1. STS-induced death is enhanced in UCP2hi MIA PaCa-2 and UCP2hi U-87 MG cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd6759729189648c18d33ba370ecc4d
https://doi.org/10.1158/0008-5472.22402055.v1

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Data from Mitochondrial Retrograde Signaling Mediated by UCP2 Inhibits Cancer Cell Proliferation and Tumorigenesis

Cancer cells tilt their energy production away from oxidative phosphorylation (OXPHOS) toward glycolysis during malignant progression, even when aerobic metabolism is available. Reversing this phenomenon, known as the Warburg effect, may offer a gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5465214a756732aa50594c44df14205d
https://doi.org/10.1158/0008-5472.c.6505976

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RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Autor: Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues

Publikováno v: Hepatology
Hepatology, 2022, ⟨10.1002/hep.32756⟩

International audience; Background and aims: Receptor-interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493ae232d3c72a04d1742cbb9981f75f
https://hal.science/hal-03873805/document

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Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes

Autor: Béatrice Morio, Arthur Bassot, Olivier Berdeaux, Stéphanie Cabaret, Johan Perrier, Emmanuelle Loizon, Anaïs Alves, Carina Prip-Buus, Jingwei Ji-Cao, Véronique Lenoir, Marie-Agnès Berger, Baptiste Panthu, Jennifer Rieusset

Publikováno v: Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, Elsevier, 2021, 1866 (12), pp.159030. ⟨10.1016/j.bbalip.2021.159030⟩

International audience; In the liver, contact sites between the endoplasmic reticulum (ER) and mitochondria (named MAMs) may be crucial hubs for the regulation of lipid metabolism, thus contributing to the exacerbation or prevention of fatty liver. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f00702701c8d068a19e4d34ba74ce9
https://hal.inrae.fr/hal-03325686

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Hypertonic external medium represses cellular respiration and promotes Warburg/Crabtree effect

Autor: Raymond Abolhassani, Frédéric Bouillaud, Laurent Schwartz, Minoo Hamraz, Mireille Andriamihaja, Véronique Lenoir, Céline Ransy

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (1), pp.222-236. ⟨10.1096/fj.201900706RR⟩

Hyperosmotic conditions are associated to several pathological states. In this article, we evaluate the consequence of hyperosmotic medium on cellular energy metabolism. We demonstrate that exposure of cells to hyperosmotic conditions immediately red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6deee5b52412798cb8cc652d8e40803
https://hal.inrae.fr/hal-02985594

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