RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity

Autor: Elias Abdou, María P. Jiménez de Bagüés, Ignacio Martínez-Abadía, Safia Ouahrani-Bettache, Véronique Pantesco, Alessandra Occhialini, Sascha Al Dahouk, Stephan Köhler, Véronique Jubier-Maurin

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)

For aerobic human pathogens, adaptation to hypoxia is a critical factor for the establishment of persistent infections, as oxygen availability is low inside the host. The two-component system RegB/A of Brucella suis plays a central role in the contro

Externí odkaz: https://doaj.org/article/072cfdf2541e4d8ba3a7e95c80186ea5

Requirement of norD for Brucella suis Virulence in a Murine Model of In Vitro and In Vivo Infection

Autor: Eugénie Bassères, Stephan Köhler, Jacques Dornand, Jean-Pierre Liautard, Véronique Jubier-Maurin, Séverine Loisel-Meyer, María Pilar Jiménez de Bagüés

Publikováno v: Infection and Immunity. 74:1973-1976

A mutant of Brucella suis bearing a Tn 5 insertion in norD , the last gene of the operon norEFCBQD , encoding nitric oxide reductase, was unable to survive under anaerobic denitrifying conditions. The norD strain exhibited attenuated multiplication w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7486b4b1ba8e01f756b68065ba67a4
https://doi.org/10.1128/iai.74.3.1973-1976.2006

Quantitative analysis of the Brucella suis proteome reveals metabolic adaptation to long-term nutrient starvation

Autor: Sascha Al Dahouk, Stephan Köhler, Véronique Jubier-Maurin, Heinrich Neubauer

Publikováno v: BMC microbiology 13, 199 (2013). doi:10.1186/1471-2180-13-199
BMC Microbiology
BMC Microbiology, BioMed Central, 2013, 13 (1), pp.199. ⟨10.1186/1471-2180-13-199⟩

BMC microbiology 13, 199 (2013). doi:10.1186/1471-2180-13-199
Published by BioMed Central [u.a.], London [u.a.]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efba56e3eb8f15345723972090e9388c

Quantitative analysis of the intramacrophagic Brucella suis proteome reveals metabolic adaptation to late stage of cellular infection

Autor: Wolfram Karges, Holger C. Scholz, Heinrich Neubauer, Stephan Köhler, Véronique Jubier-Maurin, Sascha Al Dahouk, Herbert Tomaso

Publikováno v: Proteomics
Proteomics, Wiley-VCH Verlag, 2008, 8 (18), pp.3862-3870. ⟨10.1002/pmic.200800026⟩

A 2-D DIGE approach allowed the characterization of the intramacrophagic proteome of the intracellular pathogen Brucella suis at the late stage of in vitro infection by efficient discrimination between bacterial and host cell proteins. Using a subtra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914bcf626d69732b76fe3a87c7db1246
https://hal.archives-ouvertes.fr/hal-00311701

Differential use of the two high-oxygen-affinity terminal oxidases of Brucella suis for in vitro and intramacrophagic multiplication

Autor: Stephan Köhler, Véronique Jubier-Maurin, Séverine Loisel-Meyer, María Pilar Jiménez de Bagüés, Jean-Pierre Liautard

Publikováno v: Infection and immunity. 73(11)

Expression of the high-oxygen-affinity cytochrome cbb3 and cytochrome bd ubiquinol oxidases of Brucella suis was studied in vitro and in the intramacrophagic niche, which was previously proposed to be oxygen limited. The cytochrome cbb3 oxidase was e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d77075187d8bd0c294a7784e7e81fa
https://pubmed.ncbi.nlm.nih.gov/16239582