Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Véronique Gire"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 11, Pp 1-11 (2024)
Abstract The TP53 gene encodes p53, a transcription factor involved in tumor suppression. However, TP53 also encodes other protein isoforms, some of which can disrupt the tumor suppressor functions of p53 even in the absence of TP53 mutations. In par
Externí odkaz:
https://doaj.org/article/6a0d041eea154a9eb9046cb2fcf8303c
Autor:
Gérald Lossaint, Anđela Horvat, Véronique Gire, Katarina Bačević, Karim Mrouj, Fabienne Charrier-Savournin, Virginie Georget, Daniel Fisher, Vjekoslav Dulić
Publikováno v:
Journal of Cell Science
Journal of Cell Science, 2022, 135 (8), ⟨10.1242/jcs.259114⟩
Journal of Cell Science, 2022, 135 (8), ⟨10.1242/jcs.259114⟩
Senescence is an irreversible withdrawal from cell proliferation that can be initiated after DNA damage-induced cell cycle arrest in G2 phase to prevent genomic instability. Senescence onset in G2 requires p53 (also known as TP53) and retinoblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a72e66847802b1cccca237d49765ec
https://doi.org/10.1242/jcs.259114
https://doi.org/10.1242/jcs.259114
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 22 (23), pp.13173. ⟨10.3390/ijms222313173⟩
International Journal of Molecular Sciences, Vol 22, Iss 13173, p 13173 (2021)
International Journal of Molecular Sciences, 2021, 22 (23), pp.13173. ⟨10.3390/ijms222313173⟩
International Journal of Molecular Sciences, Vol 22, Iss 13173, p 13173 (2021)
International audience; Cellular senescence entails a state of an essentially irreversible proliferative arrest in which cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic factors as part of the senescence-assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2577171216ee9f5725a7fb14c3de98a5
https://hal.science/hal-03626771/file/ijms-22-13173-v3.pdf
https://hal.science/hal-03626771/file/ijms-22-13173-v3.pdf
Publikováno v:
Nucleic Acids Research
Telomeres cap the ends of chromosomes and regulate the replicative life span of human somatic cells. Telomere function is lost upon critical shortening and a p53-dependent checkpoint that detects altered telomere states at the G1/S transition was pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dded5b7021ff1153bfd0e7e75d042b31
https://doi.org/10.1093/nar/gks1121
https://doi.org/10.1093/nar/gks1121
Publikováno v:
Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2010, 123 (Pt 8), pp.1295-305. ⟨10.1242/jcs.061002⟩
Journal of Cell Science, Company of Biologists, 2010, 123 (Pt 8), pp.1295-305. ⟨10.1242/jcs.061002⟩
International audience; Mutations in the p53 tumour suppressor gene are associated clinically with tumour progression and metastasis. Downregulation of the E-cadherin cell-cell adhesion molecule is a key event for epithelial to mesenchymal transition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80825b860995e8f4acbbb4aa4a95f87
https://doi.org/10.1242/jcs.061002
https://doi.org/10.1242/jcs.061002
Autor:
Maguy Del Rio, Gilles Gadea, Suzanne Vigneron, Anna Castro, Véronique Gire, Lydia Lartigue, Jorge Vera, Thierry Lorca, Frédéric Chibon, Isabelle Soubeyran
Publikováno v:
eLife, Vol 4 (2015)
eLife
eLife, 2015, 4, ⟨10.7554/eLife.10115⟩
eLife, eLife Sciences Publication, 2015, 4, ⟨10.7554/eLife.10115⟩
eLife
eLife, 2015, 4, ⟨10.7554/eLife.10115⟩
eLife, eLife Sciences Publication, 2015, 4, ⟨10.7554/eLife.10115⟩
The PP2A phosphatase is often inactivated in cancer and is considered as a tumour suppressor. A new pathway controlling PP2A activity in mitosis has been recently described. This pathway includes the Greatwall (GWL) kinase and its substrates endosulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3c7f6277d6d808d143691c31f2c630
https://elifesciences.org/articles/10115
https://elifesciences.org/articles/10115
Author response: Greatwall promotes cell transformation by hyperactivating AKT in human malignancies
Autor:
Maguy Del Rio, Suzanne Vigneron, Gilles Gadea, Frédéric Chibon, Jorge Vera, Lydia Lartigue, Isabelle Soubeyran, Véronique Gire, Thierry Lorca, Anna Castro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0c2286ea539a3bfa2398cb5f3e8e9e3
https://doi.org/10.7554/elife.10115.029
https://doi.org/10.7554/elife.10115.029
Autor:
Véronique Gire, Vjekoslav Dulic
Publikováno v:
Cell Cycle
Cell Cycle, Taylor & Francis, 2015, 14 (3), pp.297--304. ⟨10.1080/15384101.2014.1000134⟩
Cell Cycle, Taylor & Francis, 2015, 14 (3), pp.297--304. ⟨10.1080/15384101.2014.1000134⟩
Senescence was classically defined as an irreversible cell cycle arrest in G1 phase (G1 exit) triggered by eroded telomeres in aged primary cells. The molecular basis of this G1 arrest is thought to be due to a DNA damage response, resulting in accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df56eec192882d859add5f881a504a46
https://hal.archives-ouvertes.fr/hal-01883495
https://hal.archives-ouvertes.fr/hal-01883495
Autor:
Véronique Gire
Publikováno v:
Cell Cycle. 3:1217-1220
Loss of telomere integrity can have two outcomes with opposite predicted effects on tumorigenesis. On the one hand, shortened telomeres in normal cells may trigger cell cycle arrest, leading to tumour suppression. On the other hand, in a tumour cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f3750d63e20352493a0be419f13234
https://doi.org/10.4161/cc.3.10.1167
https://doi.org/10.4161/cc.3.10.1167
Publikováno v:
The EMBO Journal. 22:3992-4002
Although the Cdk inhibitor p21(Waf1/Cip1), one of the transcriptional targets of p53, has been implicated in the maintenance of G(2) arrest after DNA damage, its function at this stage of the cell cycle is not really understood. Here, we show that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99eb332f5f009fb009bf1f8e6ebff51
https://doi.org/10.1093/emboj/cdg387
https://doi.org/10.1093/emboj/cdg387