Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Véronique Do-Vale"'
Autor:
Hélène Goulaouic, Loreley Calvet, Conception Nemecek, Anne-Marie Lefebvre, Christelle Castell, Elisa Francesconi, Céline Lefranc, Sandrine Valence, Jean-Paul Nicolas, Tsiala Bénard, Fabrice Bonche, Jessica Mestadier, Véronique Do-Vale, Françoise Bégassat, Christine Delaisi, Mireille Kenigsberg, Coumaran Egile
Supplemental Tables S1-S3. Table S1 describes the antiproliferative activity of SAR125844 on a panel of cell lines and the known genetic alterations of MET and other oncogenes or tumor suppressor genes for these cell lines. Table S2 describes the ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eaf802bc9cf0f49d0972cbab5e7ce22
https://doi.org/10.1158/1535-7163.22503330
https://doi.org/10.1158/1535-7163.22503330
Autor:
Jessica Mestadier, Sandrine Valence, Elisa Francesconi, Conception Nemecek, Mireille Kenigsberg, Celine Lefranc, Véronique Do-Vale, Tsiala Benard, Françoise Bégassat, Fabrice Bonche, Hélène Goulaouic, Loreley Calvet, Jean-Paul Nicolas, Coumaran Egile, Christelle Castell, Christine Delaisi, Anne-Marie Lefebvre
Publikováno v:
Molecular Cancer Therapeutics. 14:384-394
Activation of the MET/HGF pathway is common in human cancer and is thought to promote tumor initiation, metastasis, angiogenesis, and resistance to diverse therapies. We report here the pharmacologic characterization of the triazolopyridazine derivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0beefff4d1ef21d5059e266e3201cd6
https://doi.org/10.1158/1535-7163.mct-14-0428
https://doi.org/10.1158/1535-7163.mct-14-0428
Autor:
Véronique Do-Vale, Fabrice Bonche, Tsiala Benard, Mireille Kenigsberg, Jean-Paul Nicolas, Coumaran Egile, Christoph Lengauer, Jessica Mestadier, Conception Nemecek, Françoise Bégassat, Loreley Calvet, Hélène Goulaouic, Christine Delaisi
Publikováno v:
Cancer Research. 72:845-845
SAR125844 is a potent MET kinase inhibitor for intravenous (IV) administration, with nanomolar activity against the wild-type enzyme (IC50 = 4.2 nM) and some kinase domain mutants, such as M1250T and Y1235D. It is highly selective for MET kinase in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e43d804e12437d8ab2c8b48d1936840a
https://doi.org/10.1158/1538-7445.am2012-845
https://doi.org/10.1158/1538-7445.am2012-845