Human plasma pregnancy-associated miRNAs and their temporal variation within the first trimester of pregnancy

Autor: Cécilia Légaré, Andrée-Anne Clément, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Simon-Pierre Guay, Benoit J. Arsenault, Michelle S. Scott, Pierre-Étienne Jacques, Patrice Perron, Renée Guérin, Marie-France Hivert, Luigi Bouchard

Publikováno v: Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-13 (2022)

Abstract Background During pregnancy, maternal metabolism undergoes substantial changes to support the developing fetus. Such changes are finely regulated by different mechanisms carried out by effectors such as microRNAs (miRNAs). These small non-co

Externí odkaz: https://doaj.org/article/fcbd58a1d66b40708e2736977b1c3050

Maternal Body Mass Index Is Associated with Profile Variation in Circulating MicroRNAs at First Trimester of Pregnancy

Autor: Kathrine Thibeault, Cécilia Légaré, Véronique Desgagné, Frédérique White, Andrée-Anne Clément, Michelle S. Scott, Pierre-Étienne Jacques, Renée Guérin, Patrice Perron, Marie-France Hivert, Luigi Bouchard

Publikováno v: Biomedicines, Vol 10, Iss 7, p 1726 (2022)

Many women enter pregnancy with overweight and obesity, which are associated with complications for both the expectant mother and her child. MicroRNAs (miRNAs) are short non-coding RNAs that regulate many biological processes, including energy metabo

Externí odkaz: https://doaj.org/article/99b2f5efb738465990a8314c22eb3e4b

SERPINE1 DNA Methylation Levels Quantified in Blood Cells at Five Years of Age Are Associated with Adiposity and Plasma PAI-1 Levels at Five Years of Age

Autor: Amelie Taschereau, Véronique Desgagné, Sabrina Faleschini, Renée Guérin, Catherine Allard, Patrice Perron, Marie-France Hivert, Luigi Bouchard

Publikováno v: International Journal of Molecular Sciences. 23:11833

Plasminogen activator inhibitor (PAI-1) expression has been associated with a higher risk of development of obesity. DNA methylation (DNAm) is an epigenetic mechanism regulating gene transcription and likely involved in the fetal programming of child

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::897986a6ed8b37e1ec3902919a43f805
https://doi.org/10.3390/ijms231911833

Placental Epigenome-Wide Association Study Identified Loci Associated with Childhood Adiposity at 3 Years of Age

Autor: Kathrine Thibeault, Élise Girard Tremblay, Patrice Perron, Marie-France Hivert, Renée Guérin, Edith Breton, Véronique Desgagné, Valérie Gagné-Ouellet, Carol-Ann Fortin, Andres Cardenas, Luigi Bouchard

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 7201, p 7201 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 19
International journal of molecular sciences, vol 21, iss 19

The aim of this study was to identify placental DNA methylation (DNAm) variations associated with adiposity at 3 years of age. We quantified placental DNAm using the Infinium MethylationEPIC BeadChips. We assessed associations between DNAm at single-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbdcddc1d53a7f0b8423f2d5f141dcd
https://www.mdpi.com/1422-0067/21/19/7201

Human high-density lipoprotein microtranscriptome is unique and suggests an extended role in lipid metabolism

Autor: Samuel Picard, Véronique Desgagné, Luigi Bouchard, Elizabeth Hutchins, Marjorie Boyer, Renée Guérin, Kendall Van Keuren-Jensen, Benoit J. Arsenault, François Corbin, Alexandre Maréchal, Simon-Pierre Guay

Publikováno v: Epigenomics. 11(8)

Aim: To comprehensively characterize the high-density lipoproteins (HDLs) microtranscriptome and to assess whether it is distinct from that of plasma and different between women and men. Methods: RNA was extracted from ultracentrifugation-purified HD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7156f336e0a85577254418953ebfe43
https://pubmed.ncbi.nlm.nih.gov/31144512