Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure

Autor: Roman Walle, Anna Petitbon, Giulia R. Fois, Christophe Varin, Enrica Montalban, Lola Hardt, Andrea Contini, Maria Florencia Angelo, Mylène Potier, Rodrigue Ortole, Asma Oummadi, Véronique De Smedt-Peyrusse, Roger A. Adan, Bruno Giros, Francis Chaouloff, Guillaume Ferreira, Alban de Kerchove d’Exaerde, Fabien Ducrocq, François Georges, Pierre Trifilieff

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Accumulating evidence points to dysregulations of the Nucleus Accumbens (NAc) in eating disorders (ED), however its precise contribution to ED symptomatic dimensions remains unclear. Using chemogenetic manipulations in male mice, we found th

Externí odkaz: https://doaj.org/article/dd0a804b992d4f64bb491a79e353f3d3

Prevention of Stress-Induced Depressive-like Behavior by Saffron Extract Is Associated with Modulation of Kynurenine Pathway and Monoamine Neurotransmission

Autor: Camille Monchaux De Oliveira, Véronique De Smedt-Peyrusse, Jennifer Morael, Sylvie Vancassel, Lucile Capuron, David Gaudout, Line Pourtau, Nathalie Castanon

Publikováno v: Pharmaceutics, Vol 13, Iss 12, p 2155 (2021)

Depressive disorders are a major public health concern. Despite currently available treatment options, their prevalence steadily increases, and a high rate of therapeutic failure is often reported, together with important antidepressant-related side

Externí odkaz: https://doaj.org/article/7e1910a53c714431a0fc0583041bebe1

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Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling

Autor: Marie-Lise Jobin, Véronique De Smedt-Peyrusse, Fabien Ducrocq, Rim Baccouch, Asma Oummadi, Maria Hauge Pedersen, Brian Medel-Lacruz, Maria-Florencia Angelo, Sandrine Villette, Pierre Van Delft, Laetitia Fouillen, Sébastien Mongrand, Jana Selent, Tarson Tolentino-Cortez, Gabriel Barreda-Gómez, Stéphane Grégoire, Elodie Masson, Thierry Durroux, Jonathan A. Javitch, Ramon Guixà-González, Isabel D. Alves, Pierre Trifilieff

Publikováno v: Molecular psychiatry.

Increasing evidence supports a relationship between lipid metabolism and mental health. In particular, the biostatus of polyunsaturated fatty acids (PUFAs) correlates with some symptoms of psychiatric disorders, as well as the efficacy of pharmacolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a77e4c19183a331af0c70dfe06be23
https://pubmed.ncbi.nlm.nih.gov/36604603

Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing

Autor: Marie-Charlotte Allichon, Ying Zhu, Roman Walle, Vincent Kappes, Andry Andrianarivelo, Naguib Mechawar, Jocelyne Caboche, Jacques Barik, Nicolas Heck, Paula A. Pousinha, Peter Vanhoutte, Véronique De Smedt-Peyrusse, Pierre Trifilieff, Gustavo Turecki, Anna Petitbon, Estefani Saint-Jour, Sebastian P. Fernandez, Vanesa Ortiz, Jonathan A. Javitch, Charlène Joséphine, Alexis-Pierre Bemelmans, Sandrine Betuing

Publikováno v: Science Advances
Science Advances, 2021, 7, pp.1-17. ⟨10.1126/sciadv.abg5970⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7, pp.1-17. ⟨10.1126/sciadv.abg5970⟩
Science Advances, 2021, 7 (43), ⟨10.1126/sciadv.abg5970⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (43), ⟨10.1126/sciadv.abg5970⟩

Description
D2R-NMDAR receptor heteromers are potential therapeutic targets in drug addiction.
Addictive drugs increase dopamine in the nucleus accumbens (NAc), where it persistently shapes excitatory glutamate transmission and hijacks natu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ffa97c632501a58bb02dd686d8d1015
https://hal.science/hal-03389497/document