Molecular and Functional Study of Transient Receptor Potential Vanilloid 1-4 at the Rat and Human Blood–Brain Barrier Reveals Interspecies Differences

Autor: Huilong Luo, Bruno Saubamea, Stéphanie Chasseigneaux, Véronique Cochois, Maria Smirnova, Fabienne Glacial, Nicolas Perrière, Catarina Chaves, Salvatore Cisternino, Xavier Declèves

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Transient receptor potential vanilloid 1-4 (TRPV1-4) expression and functionality were investigated in brain microvessel endothelial cells (BMEC) forming the blood–brain barrier (BBB) from rat and human origins. In rat, Trpv1-4 were detected by qRT

Externí odkaz: https://doaj.org/article/f367cf1943ff4c6e91196b4b2b382f4f

Modifications of physical and functional integrity of the blood-brain barrier in an inducible mouse model of neurodegeneration

Autor: Delphine Valente, Camille Taccola, Bruno Saubaméa, Véronique Cochois, Fanchon Bourasset, Stéphanie Chasseigneaux, Virginie Mignon, Xavier Declèves, Agnès Dodacki, Emmanuel Curis, Nathalie Schussler, Pascal Barneoud, Murielle Lochus, Sylvaine Cartot-Cotton, Sophie Nicolic, Salvatore Cisternino

Publikováno v: Neuropharmacology. 191:108588

The inducible p25 overexpression mouse model recapitulate many hallmark features of Alzheimer's disase including progressive neuronal loss, elevated Aβ, tau pathology, cognitive dysfunction, and impaired synaptic plasticity. We chose p25 mice to eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33507be1963b3372e773a711f0df411e
https://doi.org/10.1016/j.neuropharm.2021.108588

Cloning and cerebral expression of the guinea pig histamine H3 receptor

Autor: Véronique Cochois, J. Tardivel-Lacombe, A. Rouleau, Catherine Pillot, Anne Héron, S. Morisset, Jean-Michel Arrang, Jean-Charles Schwartz

Publikováno v: NeuroReport. 11:755-759

We cloned the full length guinea pig H 3 receptor cDNA using RT-PCR amplification with primers from the human receptor and templates from brain areas. Evidence was obtained for two isoformes, designated H 3 L and H 3 S, differing by a 30 amino acid s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea634ac4e51dfef7325501e3da7757d
https://doi.org/10.1097/00001756-200003200-00020

Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2

Autor: Salvatore Cisternino, Cynthia Marie-Claire, Maria Smirnova, Alfred H. Schinkel, Julie Cattelotte, Pascal André, Jean-Michel Scherrmann, Véronique Cochois-Guégan, Bruno Saubaméa

Publikováno v: Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2012, 32 (11), pp.1989-2001. ⟨10.1038/jcbfm.2012.109⟩

Uptake1 and uptake2 transporters are involved in the extracellular clearance of biogenic amine neurotransmitters at synaptic clefts. We looked for them at the blood–brain barrier (BBB) and blood–retina barriers (BRB), where they could be involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b9f6485f909534a979a2a1a8853810
https://pubmed.ncbi.nlm.nih.gov/22850405

Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans

Autor: Véronique Cochois, Nicolas Bizat, Jean-Louis Laplanche, Christian Neri, Jean-Michel Peyrin, Patrick Beaudry, Stéphane Haïk

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(15)

Although prion propagation is well understood, the signaling pathways activated by neurotoxic forms of prion protein (PrP) and those able to mitigate pathological phenotypes remain largely unknown. Here, we identifysrc-2, a Fyn-related kinase, as a g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e3878239bb596ee2b80cc5bfc24331
https://pubmed.ncbi.nlm.nih.gov/20392961