Arterial Myogenic Activation through Smooth Muscle Filamin A

Autor: Kevin Retailleau, Malika Arhatte, Sophie Demolombe, Rémi Peyronnet, Véronique Baudrie, Martine Jodar, Jennifer Bourreau, Daniel Henrion, Stefan Offermanns, Fumihiko Nakamura, Yuanyi Feng, Amanda Patel, Fabrice Duprat, Eric Honoré

Publikováno v: Cell Reports, Vol 14, Iss 9, Pp 2050-2058 (2016)

Mutations in the filamin A (FlnA) gene are frequently associated with severe arterial abnormalities, although the physiological role for this cytoskeletal element remains poorly understood in vascular cells. We used a conditional mouse model to selec

Externí odkaz: https://doaj.org/article/d1f7b028b48143ab8d57f380cdfe5027

Endothelial S1P

Autor: Teresa Sanchez, Hira Niazi, Bertrand Tavitian, Hiroki Uchida, Aline Chevallier, Véronique Baudrie, Lidia Garcia-Bonilla, Christiane Charriaut-Marlangue, Anja Nitzsche, Costantino Iadecola, Marine Poittevin, Nathalie Kubis, Susan R. Schwab, Mari Kono, Daniel Henrion, Giuseppe Faraco, Richard L. Proia, Manuela Cl Garcia, Eric Camerer, Patrice Therond, Timothy Hla, Pierre-Louis Tharaux, Pierre-Louis Leger, Jerold Chun, Julie Favre, Philippe Bonnin, Thomas Mathivet, Ludovic Couty, Gwennhael Autret, Ammar Benarab, Anne Eichmann

Publikováno v: Circ Res
Circulation Research
Circulation Research, 2021, 128 (3), pp.363-382. ⟨10.1161/CIRCRESAHA.120.316711⟩

Rationale: Cerebrovascular function is critical for brain health, and endogenous vascular protective pathways may provide therapeutic targets for neurological disorders. S1P (Sphingosine 1-phosphate) signaling coordinates vascular functions in other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8446c110a74dfacb71d947b6264ee510
https://pubmed.ncbi.nlm.nih.gov/33539221

Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing

Autor: Najet Debili, Benoit Decouture, Sylvain Provot, Mari Kono, Eric Camerer, Ludovic Couty, Richard L. Proia, Maria L. Allende, Boubacar Mariko, Erica De Candia, Sonia Poirault-Chassac, Hira Niazi, Pierre-Louis Tharaux, Pierre Hadrien Becker, Véronique Baudrie, Christilla Bachelot-Loza, Rameez Ishaq, Nesrine Zoghdani, Anja Nitzsche, Alexandre Leuci, Yetki Aslan, Salome L. Gazit, Jerold Chun, Ammar Benarab, Patrice Therond, Pascale Gaussem

Publikováno v: Blood Advances
Blood Advances, The American Society of Hematology, 2019, 3 (11), pp.1702-1713. ⟨10.1182/bloodadvances.2019031948⟩
Blood Advances, 2019, 3 (11), pp.1702-1713. ⟨10.1182/bloodadvances.2019031948⟩

International audience; Key points • The vascular S1Pgradient is dispensablefor platelet formationin mice• Instead, local S1P production restrains megakaryopoiesis via S1P 1 and can further suppress platelet production via S1P 2 when deregulated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2551795b23070694c0b2fa2f3eb1b57
https://www.hal.inserm.fr/inserm-02441591/document

A mouse model of pseudohypoaldosteronism type II reveals a novel mechanism of renal tubular acidosis

Autor: Jennifer Baraka-Vidot, María Chávez-Canales, Régine Chambrey, Juliette Hadchouel, Alexia Pillot, Maximilien Jayat, Yusuke Kumai, Karen I. López-Cayuqueo, Christelle Soukaseum, Dominique Eladari, Xavier Jeunemaitre, Francesco Trepiccione, Véronique Baudrie, Cara Büsst, Pascal Houillier

Publikováno v: Kidney International
Kidney International, Nature Publishing Group, 2018, 94 (3), pp.514-523. ⟨10.1016/j.kint.2018.05.001⟩

Pseudohypoaldosteronism type II (PHAII) is a genetic disease characterized by association of hyperkalemia, hyperchloremic metabolic acidosis, hypertension, low renin, and high sensitivity to thiazide diuretics. It is caused by mutations in the WNK1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3134499d75ae561140543bd8b36da7
https://hal.archives-ouvertes.fr/hal-02378416

Notice of Removal: Insight in vascular fragility induced by collagen structural change using ultrafast ultrasound imaging in a mouse model of vascular Ehlers-Danlos syndrome

Autor: Guillaume Goudot, Véronique Baudrie, Tristan Mirault, Irmine Ferreira, Mathieu Pernot, Mickael Tanter, Emmanuel Messas, Xavier Jeunemaitre

Publikováno v: 2017 IEEE International Ultrasonics Symposium (IUS).

Multiple collagen types are critical for proper function of the vascular system, with type III being responsible for imparting strength in the vessel wall. Patients with mutant gene encoding type III collagen experience arterial ruptures, called vasc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fca6d0d21b44e9bd1a30abb1f66a94f1
https://doi.org/10.1109/ultsym.2017.8092097