Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity

Autor: Cintia L. Araujo Furlan, Jimena Tosello Boari, Constanza Rodriguez, Fernando P. Canale, Facundo Fiocca Vernengo, Santiago Boccardo, Cristian G. Beccaria, Véronique Adoue, Olivier Joffre, Adriana Gruppi, Carolina L. Montes, Eva V. Acosta Rodriguez

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

While it is now acknowledged that CD4+ T cells expressing CD25 and Foxp3 (Treg cells) regulate immune responses and, consequently, influence the pathogenesis of infectious diseases, the regulatory response mediated by Treg cells upon infection by Try

Externí odkaz: https://doaj.org/article/89675fb7b2c64350af68960726eb620a

Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.

Autor: Amidou N'Diaye, Gary K Chen, Cameron D Palmer, Bing Ge, Bamidele Tayo, Rasika A Mathias, Jingzhong Ding, Michael A Nalls, Adebowale Adeyemo, Véronique Adoue, Christine B Ambrosone, Larry Atwood, Elisa V Bandera, Lewis C Becker, Sonja I Berndt, Leslie Bernstein, William J Blot, Eric Boerwinkle, Angela Britton, Graham Casey, Stephen J Chanock, Ellen Demerath, Sandra L Deming, W Ryan Diver, Caroline Fox, Tamara B Harris, Dena G Hernandez, Jennifer J Hu, Sue A Ingles, Esther M John, Craig Johnson, Brendan Keating, Rick A Kittles, Laurence N Kolonel, Stephen B Kritchevsky, Loic Le Marchand, Kurt Lohman, Jiankang Liu, Robert C Millikan, Adam Murphy, Solomon Musani, Christine Neslund-Dudas, Kari E North, Sarah Nyante, Adesola Ogunniyi, Elaine A Ostrander, George Papanicolaou, Sanjay Patel, Curtis A Pettaway, Michael F Press, Susan Redline, Jorge L Rodriguez-Gil, Charles Rotimi, Benjamin A Rybicki, Babatunde Salako, Pamela J Schreiner, Lisa B Signorello, Andrew B Singleton, Janet L Stanford, Alex H Stram, Daniel O Stram, Sara S Strom, Bhoom Suktitipat, Michael J Thun, John S Witte, Lisa R Yanek, Regina G Ziegler, Wei Zheng, Xiaofeng Zhu, Joseph M Zmuda, Alan B Zonderman, Michele K Evans, Yongmei Liu, Diane M Becker, Richard S Cooper, Tomi Pastinen, Brian E Henderson, Joel N Hirschhorn, Guillaume Lettre, Christopher A Haiman

Publikováno v: PLoS Genetics, Vol 7, Iss 10, p e1002298 (2011)

Adult height is a classic polygenic trait of high heritability (h(2) approximately 0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey mod

Externí odkaz: https://doaj.org/article/235df6289e8c4e67b0d8cbb11e6a5b1a

[Endogenous retroviruses: friend or foe of the immune system?]

Autor: Véronique, Adoue, Olivier, Joffre

Publikováno v: Medecine sciences : M/S. 36(3)

Upon priming by dendritic cells, naïve CD4 T lymphocytes are exposed to distinct molecular environments depending on the nature of the pathological stimulus. In response, they mobilize different gene networks that establish lineage-specific developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31aba509f68d6dc430987782f7726de7
https://pubmed.ncbi.nlm.nih.gov/32228844

Critical role for TRIM28 and HP1β/γ in the epigenetic control of T cell metabolic reprograming and effector differentiation

Autor: Marianne Burbage, Pablo J. Sáez, Deborah Lefevre, Thomas Hoyler, Amal Zine El Aabidine, Rébecca Panes, Guadalupe Suarez, Christel Goudot, Sebastian Amigorena, Jean-Marie Carpier, Mengliang Ye, Fanny Aprahamian, Claire Hivroz, Florence Cammas, Olivier Joffre, Véronique Adoue, Elina Zueva, Jean-Christophe Andrau, Angelique Bellemare-Pelletier, Sylvère Durand, Leonel Joannas, Etienne Gagnon, Maqbool Muhammad Ahmad, Guido Kroemer, Cyril Esnault, Ulf Gehrmann, Sandrine Heurtebise-Chrétien, Nina Burgdorf

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (51), pp.25839-25849. ⟨10.1073/pnas.1901639116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (51), pp.25839-25849. ⟨10.1073/pnas.1901639116⟩

Significance CD4 T cells are major regulators of immune responses against both self and pathogens. Understanding pathways that govern CD4 T cell differentiation and regulation are thus key for the discovery of new immunoregulatory drug targets. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdc87a7d673a9a3997e6fdd23ac6a75
https://hal.archives-ouvertes.fr/hal-02369616/document

Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21

Autor: Melissa C. Southey, Qin Wang, Paolo Radice, Robert Winqvist, Vesa Kataja, Anna Jakubowska, Audrey Lemaçon, Elinor J. Sawyer, Hermann Brenner, Pascal Guénel, Heli Nevanlinna, Judith S. Brand, Patrick Neven, Mark S. Goldberg, Jan Lubinski, P. D. P Pharoah, Sara Margolin, Vessela N. Kristensen, Bernardo Bonanni, Anna González-Neira, Ian Tomlinson, Thérèse Truong, Anne Lise Børresen-Dale, Natalia Bogdanova, Marjanka K. Schmidt, Thilo Dörk, Grethe I. GrenakerAlnæs, Wei Zheng, Celine M. Vachon, Diether Lambrechts, Isabel dos-Santos-Silva, Alison M. Dunning, Annegien Broeks, Douglas F. Easton, Javier Benitez, Michael Jones, Hoda Anton-Culver, Véronique Adoue, Sander Canisius, Roger L. Milne, Ans M.W. van den Ouweland, Yosr Hamdi, Mel Maranian, Angela Cox, Aocs Investigators, Maartje J. Hooning, Dijana Plaseska-Karanfilska, Frederik Marmé, Volker Arndt, Simon S. Cross, Silje Nord, Stig E. Bojesen, Kyriaki Michailidou, Penny Soucy, Joe Dennis, Hiltrud Brauch, Anja Rudolph, Rob A. E. M. Tollenaar, Arto Mannermaa, Maria Kabisch, Christopher A. Haiman, Susan L. Neuhausen, Loic Le Marchand, Katri Pylkäs, Irene L. Andrulis, Xiao-Ou Shu, Caroline Baynes, kConFab, Peter Devilee, Georgia Chenevix-Trench, Annika Lindblom, Emily Hallberg, Diana Torres, Anthony J. Swerdlow, Graham G. Giles, Jenny Chang-Claude, Lothar Haeberle, Tomi Pastinen, Curtis Olswold, Peter A. Fasching, Montserrat Garcia-Closas, Manjeet K. Bolla, Carl Blomqvist, Mikael Eriksson, Henrik Flyger, Kamila Czene, John L. Hopper, Fergus J. Couch, Ute Hamann, Jacques Simard, Arnaud Droit, Per Hall, Jonine D. Figueroa, Hatef Darabi, Julian Peto, Barbara Burwinkel

Publikováno v: Hamdi, Y, Soucy, P, Adoue, V, Michailidou, K, Canisius, S, Lemaçon, A, Droit, A, Andrulis, I L, Anton-Culver, H, Arndt, V, Baynes, C, Blomqvist, C, Bogdanova, N V, Bojesen, S E, Bolla, M K, Bonanni, B, Borresen-Dale, A-L, Brand, J S, Brauch, H, Brenner, H, Broeks, A, Burwinkel, B, Chang-Claude, J, Couch, F J, Cox, A, Cross, S S, Czene, K, Darabi, H, Dennis, J, Devilee, P, Dörk, T, Dos-Santos-Silva, I, Eriksson, M, Fasching, P A, Figueroa, J, Flyger, H, García-Closas, M, Giles, G G, Goldberg, M S, González-Neira, A, Grenaker-Alnæs, G, Guénel, P, Haeberle, L, Haiman, C A, Hamann, U, Hallberg, E, Hooning, M J, Hopper, J L, Jakubowska, A, Jones, M & Tomlinson, I 2016, ' Association of breast cancer risk with genetic variants showing differential allelic expression : Identification of a novel breast cancer susceptibility locus at 4q21 ', Oncotarget, vol. 7, no. 49, pp. 80140-80163 . https://doi.org/10.18632/oncotarget.12818
Hamdi, Y, Soucy, P, Adoue, V, Michailidou, K, Canisius, S, Lemaçon, A, Droit, A, Andrulis, I L, Anton-Culver, H, Arndt, V, Baynes, C, Blomqvist, C, Bogdanova, N V, Bojesen, S E, Bolla, M K, Bonanni, B, Borresen-Dale, A-L, Brand, J S, Brauch, H, Brenner, H, Broeks, A, Burwinkel, B, Chang-Claude, J, Couch, F J, Cox, A, Cross, S S, Czene, K, Darabi, H, Dennis, J, Devilee, P, Dörk, T, Dos-Santos-Silva, I, Eriksson, M, Fasching, P A, Figueroa, J, Flyger, H, García-Closas, M, Giles, G G, Goldberg, M S, González-Neira, A, Grenaker-Alnæs, G, Guénel, P, Haeberle, L, Haiman, C A, Hamann, U, Hallberg, E, Hooning, M J, Hopper, J L, Jakubowska, A, Jones, M 2016, ' Association of breast cancer risk with genetic variants showing differential allelic expression : Identification of a novel breast cancer susceptibility locus at 4q21 ', Oncotarget, vol. 7, no. 49, pp. 80140-80163 . https://doi.org/10.18632/oncotarget.12818
Oncotarget
Oncotarget, 7(49), 80140-80163. Impact Journals LLC
Oncotarget, 7(49), 80140-80163
Repisalud
Instituto de Salud Carlos III (ISCIII)

There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-acting variants represent an important source of phenotypic variation. Consequently, cis-regulatory SNPs associated with d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402df6adaaf290ca651d1f1201b101f1
https://lirias.kuleuven.be/handle/123456789/555782