Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Véronique, Dubernard"'
Publikováno v:
Blood. 106:658-667
By means of its antiangiogenic activity, thrombospondin-1 (TSP-1) exerts indirect antitumoral action on solid tumors. Here, we investigated potential antitumor action in an in vitro cell model for promyelocytic leukemia (NB4-LR1), resistant to retino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01f4c7b77ad3bc15ada59a6afc7e5a4
https://doi.org/10.1182/blood-2004-09-3585
https://doi.org/10.1182/blood-2004-09-3585
Publikováno v:
Biochemical Journal. 363:473-482
Thrombospondin-1 (TSP-1) is an adhesive glycoprotein which, when secreted from α-granules of activated platelets, can bind to the cell surface and participate in platelet aggregate formation. In this study, we show that thrombin activation leads to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8500ffd7da7124f4b1ca6ed80e61a6b8
https://doi.org/10.1042/bj3630473
https://doi.org/10.1042/bj3630473
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 17:2293-2305
Abstract In a previous study, we have demonstrated that the platelet adhesive glycoprotein thrombospondin-1 (TSP-1) interacts specifically with the cytoskeletal protein α-actinin in a solid-phase binding assay. Stored in the α-granules of platelets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d4b757cc53928e4687f53ccf2bd261
https://doi.org/10.1161/01.atv.17.10.2293
https://doi.org/10.1161/01.atv.17.10.2293
Publikováno v:
Blood. 79:1995-2003
We have investigated the molecular requirements for thrombospondin (TSP) to bind to the platelet surface and to support the subsequent secretion-dependent platelet aggregation. For this, we used two distinct murine monoclonal antibodies (MoAbs), desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9d3ea0687796b0176eb41150c78698
https://doi.org/10.1182/blood.v79.8.1995.1995
https://doi.org/10.1182/blood.v79.8.1995.1995
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1033:7-12
We have designed a new binding assay based on crossed immunoelectrophoresis that allowed us to test for the relative capacities of platelet membrane glycoprotein IIb-IIIa (GP IIb-IIIa), and glycoprotein IV (GP IV) to bind purified Arg-Gly-Asp (RGD)-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7388a7837092aff62d54c62cfaee3120
https://doi.org/10.1016/0304-4165(90)90186-z
https://doi.org/10.1016/0304-4165(90)90186-z
Publikováno v:
The Biochemical journal. 363(Pt 3)
Thrombospondin-1 (TSP-1) is an adhesive glycoprotein which, when secreted from alpha-granules of activated platelets, can bind to the cell surface and participate in platelet aggregate formation. In this study, we show that thrombin activation leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a502bf9999fa72fe77c750647f68341
https://pubmed.ncbi.nlm.nih.gov/11964147
https://pubmed.ncbi.nlm.nih.gov/11964147
Publikováno v:
European Journal of Biochemistry. 142:465-471
The receptor for ADP on the platelet membrane, which triggers exposure of fibrinogen-binding sites and platelet aggregation, has not yet been identified. Two enzymes with which ADP interacts on the platelet surface, an ecto-ATPase and nucleosidedipho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed6226f1e9c378c7e2b8eff15ebb3c7
https://doi.org/10.1111/j.1432-1033.1984.tb08309.x
https://doi.org/10.1111/j.1432-1033.1984.tb08309.x
Publikováno v:
Blood. 73:1226-1234
Affinity purified anti-fibrinogen (anti-Fg) Fab fragments were used to study the mechanism of expression of alpha-granule fibrinogen on activated platelets. Low amounts of the radiolabeled anti-Fg Fab bound to unstimulated or adenosine diphosphate (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e4abaad55efe5499d95fcf1d7ed682
https://doi.org/10.1182/blood.v73.5.1226.1226
https://doi.org/10.1182/blood.v73.5.1226.1226
Publikováno v:
Biochemical and Biophysical Research Communications. 96:1-9
The binding of AMP and ADP to specific sites on the human platelet membrane have been compared. Although the two nucleotides bound to the platelet membrane with similar affinities (Ka ⋍ 0.4 × 10 6 M −1 ), AMP binding was more rapid than ADP bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36a9897495c003fde640661b165429a
https://doi.org/10.1016/0006-291x(80)91173-0
https://doi.org/10.1016/0006-291x(80)91173-0
Publikováno v:
XIth International Congress on Thrombosis and Haemostasis.
A radiolabelled monoclonal antibody (mAb) against native thrombospondin (TSP) has been used to quantitatively assess the surface exposure of intracellular TSP following platelet stimulation. This mAb, designated 5G11, was purified from ascitic fluid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbaba65ecff330866efc4e9d30885fba
https://doi.org/10.1055/s-0038-1643821
https://doi.org/10.1055/s-0038-1643821