Intrinsic Proteolytic Activities from Cancer Cells Are Sufficient to Activate Alkoxyamine Prodrugs and Induce Cell Death

Autor: Marion Filliâtre, Seda Seren, Ange W. Embo-Ibouanga, Jean-Patrick Joly, Véronique Bouchaud, Ines Kelkoul, Sylvain R. A. Marque, Gérard Audran, Pierre Voisin, Philippe Mellet

Publikováno v: ACS Omega, Vol 9, Iss 37, Pp 39004-39012 (2024)

Externí odkaz: https://doaj.org/article/a5f04c4e70a648af96e912929e0408d4

A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation.

Autor: Leslie Mazuel, Jordy Blanc, Cendrine Repond, Véronique Bouchaud, Gérard Raffard, Nicole Déglon, Gilles Bonvento, Luc Pellerin, Anne-Karine Bouzier-Sore

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0174990 (2017)

Although several in vitro and ex vivo evidence support the existence of lactate exchange between astrocytes and neurons, a direct demonstration in vivo is still lacking. In the present study, a lentiviral vector carrying a short hairpin RNA (shRNA) w

Externí odkaz: https://doaj.org/article/6e9206443d9040fc96e8fc6e092c1fea

Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance

Autor: Eduardo R. Zimmer, Imad Benkhaled, Philippe Massot, Charlotte Jollé, Hélène Roumes, Véronique Bouchaud, Nicole Déglon, Luc Pellerin, Anne-Karine Bouzier-Sore, Jordy Blanc, Marc Biran, Gérard Raffard, Carolina Piletti Chatain, Catherine Pythoud

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (47), pp.e2112466118. ⟨10.1073/pnas.2112466118⟩
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (47), ⟨10.1073/pnas.2112466118⟩
Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 47, pp. e2112466118

International audience; Lactate is an efficient neuronal energy source, even in presence of glucose. However, the importance of lactate shuttling between astrocytes and neurons for brain activation and function remains to be established. For this pur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e5102816871d75909ca2a77e66286b
https://pubmed.ncbi.nlm.nih.gov/34782470

Overhauser-enhanced MRI of elastase activity from in vitro human neutrophil degranulation.

Autor: Elodie Parzy, Véronique Bouchaud, Philippe Massot, Pierre Voisin, Neha Koonjoo, Damien Moncelet, Jean-Michel Franconi, Eric Thiaudière, Philippe Mellet

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57946 (2013)

Magnetic resonance imaging can reveal exquisite anatomical details. However several diseases would benefit from an imaging technique able to specifically detect biochemical alterations. In this context protease activity imaging is one of the most pro

Externí odkaz: https://doaj.org/article/89d523598259416986bb0dee0af1c342

Correction: Overhauser-Enhanced MRI of Elastase Activity from In Vitro Human Neutrophil Degranulation.

Autor: Elodie Parzy, Véronique Bouchaud, Philippe Massot, Pierre Voisin, Neha Koonjoo, Damien Moncelet, Jean-Michel Franconi, Eric Thiaudière, Philippe Mellet

Publikováno v: PLoS ONE, Vol 8, Iss 8 (2013)

Externí odkaz: https://doaj.org/article/71d4869ac5914f82aaa35c26794b4289