Synthesis of novel 4-Boc-piperidone chalcones and evaluation of their cytotoxic activity against highly-metastatic cancer cells.

Autor: Ocasio-Malavé C; Faculty of Science and Technology, Department of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, USA., Donate MJ; School of Pharmacy, Department of Pharmaceutical Sciences, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936, USA; University of Puerto Rico Comprehensive Cancer Center, PO Box 363027, San Juan, PR 00936, USA., Sánchez MM; University of Puerto Rico Comprehensive Cancer Center, PO Box 363027, San Juan, PR 00936, USA., Sosa-Rivera JM; School of Pharmacy, Department of Pharmaceutical Sciences, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936, USA; University of Puerto Rico Comprehensive Cancer Center, PO Box 363027, San Juan, PR 00936, USA., Mooney JW; Faculty of Science and Technology, Department of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, USA., Pereles-De León TA; Faculty of Science and Technology, Department of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, USA., Carballeira NM; Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, 17 Ave Universidad STE 1701, San Juan, PR 00925, USA., Zayas B; School of Science, Technology & Environment, Universidad Ana G. Méndez, Cupey Campus, PO Box 21150, San Juan, PR 00928, USA., Vélez-Gerena CE; School of Science, Technology & Environment, Universidad Ana G. Méndez, Cupey Campus, PO Box 21150, San Juan, PR 00928, USA., Martínez-Ferrer M; School of Pharmacy, Department of Pharmaceutical Sciences, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936, USA; University of Puerto Rico Comprehensive Cancer Center, PO Box 363027, San Juan, PR 00936, USA., Sanabria-Ríos DJ; Faculty of Science and Technology, Department of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, USA. Electronic address: dsanabria@intermetro.edu.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Jan 01; Vol. 30 (1), pp. 126760. Date of Electronic Publication: 2019 Oct 28.