Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Väinö Lithovius"'
Autor:
Tom Barsby, Eliisa Vähäkangas, Jarkko Ustinov, Hossam Montaser, Hazem Ibrahim, Väinö Lithovius, Emilia Kuuluvainen, Vikash Chandra, Jonna Saarimäki-Vire, Pekka Katajisto, Ville Hietakangas, Timo Otonkoski
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112970- (2023)
Summary: Pancreatic islets regulate blood glucose homeostasis through the controlled release of insulin; however, current metabolic models of glucose-sensitive insulin secretion are incomplete. A comprehensive understanding of islet metabolism is int
Externí odkaz:
https://doaj.org/article/ce7f7f087e48409ea41c81a3c021754a
Autor:
Vikash Chandra, Hazem Ibrahim, Clémentine Halliez, Rashmi B. Prasad, Federica Vecchio, Om Prakash Dwivedi, Jouni Kvist, Diego Balboa, Jonna Saarimäki-Vire, Hossam Montaser, Tom Barsby, Väinö Lithovius, Isabella Artner, Swetha Gopalakrishnan, Leif Groop, Roberto Mallone, Decio L. Eizirik, Timo Otonkoski
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The TYK2 gene is associated with development of type 1 diabetes. Here the authors show that TYK2 regulates β-cell development, but at the same time TYK2 inhibition in the islets prevents IFNα responses and enhances their survival against CD8+ T-cel
Externí odkaz:
https://doaj.org/article/1702551117374e95b0db57f6600d8e23
Autor:
Tom Barsby, Hazem Ibrahim, Väinö Lithovius, Hossam Montaser, Diego Balboa, Eliisa Vähäkangas, Vikash Chandra, Jonna Saarimäki-Vire, Timo Otonkoski
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101711- (2022)
Summary: We present here a robust and reliable protocol by which to differentiate pancreatic islet-like aggregates (SC-islets) from human pluripotent stem cells. The 7-stage protocol mimics developmental patterning factors that induce endocrine linea
Externí odkaz:
https://doaj.org/article/0b11521ef9d64cfb9ce2ee9d1074fc39
Autor:
Väinö Lithovius, Timo Otonkoski
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Congenital hyperinsulinism (CHI) is a severe inherited neonatal disorder characterized by inappropriate insulin secretion caused by genetic defects of the pancreatic beta cells. Several open questions remain in CHI research, such as the optimal treat
Externí odkaz:
https://doaj.org/article/382c9832cec24560b71738609333cf00
Loss of MANF Causes Childhood Onset Syndromic Diabetes due to Increased Endoplasmic Reticulum Stress
Autor:
Timo Otonkoski, Jonna Saarimäki-Vire, Andrew Hattersley, Maria Lindahl, Matthew Wakeling, Jonathan M. Locke, Kevin Colclough, Tawfeg Ben-Omran, Sezer Acar, Korcan Demir, Vikash Chandra, Anna Näätänen, Väinö Lithovius, Hazem Ibrahim, Diego Balboa, Kashyap A Patel, Hossam Montaser
MANF is an endoplasmic reticulum resident protein that plays a crucial role in attenuating ER stress responses. Although MANF is indispensable for the survival and function of mouse beta cells, its precise role in human beta cell development and func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f3101ad671df215aacff28d0c12cf3
https://doi.org/10.2337/figshare.13622993
https://doi.org/10.2337/figshare.13622993
Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress
Autor:
Hossam, Montaser, Kashyap A, Patel, Diego, Balboa, Hazem, Ibrahim, Väinö, Lithovius, Anna, Näätänen, Vikash, Chandra, Korcan, Demir, Sezer, Acar, Tawfeg, Ben-Omran, Kevin, Colclough, Jonathan M, Locke, Matthew, Wakeling, Maria, Lindahl, Andrew T, Hattersley, Jonna, Saarimäki-Vire, Timo, Otonkoski
Publikováno v:
Diabetes
MANF is an endoplasmic reticulum resident protein that plays a crucial role in attenuating ER stress responses. Although MANF is indispensable for the survival and function of mouse beta cells, its precise role in human beta cell development and func
Autor:
Diego Balboa, Tom Barsby, Väinö Lithovius, Jonna Saarimäki-Vire, Muhmmad Omar-Hmeadi, Oleg Dyachok, Hossam Montaser, Per-Eric Lund, Mingyu Yang, Hazem Ibrahim, Anna Näätänen, Vikash Chandra, Helena Vihinen, Eija Jokitalo, Jouni Kvist, Jarkko Ustinov, Anni I. Nieminen, Emilia Kuuluvainen, Ville Hietakangas, Pekka Katajisto, Joey Lau, Per-Ola Carlsson, Sebastian Barg, Anders Tengholm, Timo Otonkoski
Publikováno v:
Nature biotechnology.
Data de publicació electrònica: 03-03-2022 Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in the generation of stem-cell-derived islets (SC-islets), no det
Autor:
Hossam Montaser, Miriam Cnop, Eija Jokitalo, Cristina Cosentino, Mariana Igoillo-Esteve, Piero Marchetti, Banu Kucukemre Aydin, Valérie Senée, Decio L. Eizirik, Pierre Vanderhaeghen, Timo Otonkoski, Céline Demarez, Tushar Godbole, Jonna Saarimäki-Vire, Maria Lytrivi, Väinö Lithovius, Matthew B. Johnson, Ikuo K. Suzuki, Edip Unal, Kashyap A. Patel, Andrew T. Hattersley, Toshiaki Sawatani, Belma Haliloglu, Helena Vihinen, Mehmet Nuri Ozbek, Melek Yildiz, Ruken Yıldırım, Federica Fantuzzi, Matthew Wakeling, Sian Ellard, Hazem Ibrahim, Ying Cai, Cécile Julier, Thomas W Laver, Angéline Bilheu, Nathalie Pachera, Sarah E. Flanagan, Hadis Shakeri, Elisa De Franco
Publikováno v:
The Journal of clinical investigation, 130 (12
The Journal of Clinical Investigation
J Clin Invest
The Journal of clinical investigation.
The Journal of Clinical Investigation
J Clin Invest
The Journal of clinical investigation.
Neonatal diabetes is caused by single gene mutations reducing pancreatic β cell number or impairing β cell function. Understanding the genetic basis of rare diabetes subtypes highlights fundamental biological processes in β cells. We identified 6