Detrimental Effect of Fungal 60-kDa Heat Shock Protein on Experimental Paracoccidioides brasiliensis Infection.

Autor: Fabrício Freitas Fernandes, Leandro Licursi de Oliveira, Taise Natali Landgraf, Gabriela Peron, Marcelo Vieira Costa, Arlete A M Coelho-Castelo, Vânia L D Bonato, Maria-Cristina Roque-Barreira, Ademilson Panunto-Castelo

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0162486 (2016)

The genus Paracoccidioides comprises species of dimorphic fungi that cause paracoccidioidomycosis (PCM), a systemic disease prevalent in Latin America. Here, we investigated whether administration of native 60-kDa heat shock protein of P. brasiliensi

Externí odkaz: https://doaj.org/article/c07fff1bddf34690900108db7890b543

The Interplay among Glucocorticoid Therapy, Platelet-Activating Factor and Endocannabinoid Release Influences the Inflammatory Response to COVID-19

Autor: Jonatan C. S. de Carvalho, Pedro V. da Silva-Neto, Diana M. Toro, Carlos A. Fuzo, Viviani Nardini, Vinícius E. Pimentel, Malena M. Pérez, Thais F. C. Fraga-Silva, Camilla N. S. Oliveira, Augusto M. Degiovani, Fátima M. Ostini, Marley R. Feitosa, Rogerio S. Parra, José J. R. da Rocha, Omar Feres, Fernando C. Vilar, Gilberto G. Gaspar, Isabel K. F. M. Santos, Ana P. M. Fernandes, Sandra R. Maruyama, Elisa M. S. Russo, Vânia L. D. Bonato, Cristina R. B. Cardoso, Marcelo Dias-Baruffi, Lúcia H. Faccioli, Carlos A. Sorgi, on behalf of the ImmunoCovid Study Group

Publikováno v: Viruses, Vol 15, Iss 2, p 573 (2023)

COVID-19 is associated with a dysregulated immune response. Currently, several medicines are licensed for the treatment of this disease. Due to their significant role in inhibiting pro-inflammatory cytokines and lipid mediators, glucocorticoids (GCs)

Externí odkaz: https://doaj.org/article/8571dd7050f54f5e89a23cd7c0e0bc72

Acetylcholine, Fatty Acids, and Lipid Mediators Are Linked to COVID-19 Severity

Autor: Malena M. Pérez, Vinícius E. Pimentel, Carlos A. Fuzo, Pedro V. da Silva-Neto, Diana M. Toro, Thais F. C. Fraga-Silva, Luiz G. Gardinassi, Camilla N. S. Oliveira, Camila O. S. Souza, Nicola T. Torre-Neto, Jonatan C. S. de Carvalho, Thais C. De Leo, Viviani Nardini, Marley R. Feitosa, Rogerio S. Parra, José J. R. da Rocha, Omar Feres, Fernando C. Vilar, Gilberto G. Gaspar, Leticia F. Constant, Fátima M. Ostini, Augusto M. Degiovani, Alessandro P. Amorim, Angelina L. Viana, Ana P. M. Fernandes, Sandra R. Maruyama, Elisa M. S. Russo, Isabel K. F. M. Santos, Vânia L. D. Bonato, Cristina R. B. Cardoso, Carlos A. Sorgi, Marcelo Dias-Baruffi, Lúcia H. Faccioli

Publikováno v: The Journal of Immunology. 209:250-261

Lipid and cholinergic mediators are inflammatory regulators, but their role in the immunopathology of COVID-19 is still unclear. Here, we used human blood and tracheal aspirate (TA) to investigate whether acetylcholine (Ach), fatty acids (FAs), and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f965a5346c56b2e1dcc281d907b97fe
https://doi.org/10.4049/jimmunol.2200079

Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells

Autor: Ana C. G. Salina, Douglas dos-Santos, Tamara S. Rodrigues, Marlon Fortes-Rocha, Edismauro G. Freitas-Filho, Daniel L. Alzamora-Terrel, Ícaro M. S. Castro, Thais F. C. Fraga da Silva, Mikhael H. F. de Lima, Daniele C. Nascimento, Camila M. Silva, Juliana E. Toller-Kawahisa, Amanda Becerra, Samuel Oliveira, Diego B. Caetité, Leticia Almeida, Adriene Y. Ishimoto, Thais M. Lima, Ronaldo B. Martins, Flavio Veras, Natália B. do Amaral, Marcela C. Giannini, Letícia P. Bonjorno, Maria I. F. Lopes, Maira N. Benatti, Sabrina S. Batah, Rodrigo C. Santana, Fernando C. Vilar, Maria A. Martins, Rodrigo L. Assad, Sergio C. L. de Almeida, Fabiola R. de Oliveira, Eurico Arruda Neto, Thiago M. Cunha, José C. Alves-Filho, Vânia L. D. Bonato, Fernando Q. Cunha, Alexandre T. Fabro, Helder I. Nakaya, Dario S. Zamboni, Paulo Louzada-Junior, Rene D. R. Oliveira, Larissa D. Cunha

Publikováno v: eLife. 11

COVID-19 is a disease of dysfunctional immune responses, but the mechanisms triggering immunopathogenesis are not established. The functional plasticity of macrophages allows this cell type to promote pathogen elimination and inflammation or suppress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4982117058f5856d8deff90fc988da
https://doi.org/10.7554/elife.74443

sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity

Autor: Pedro V. da Silva-Neto, Jonatan C. S. de Carvalho, Vinícius E. Pimentel, Malena M. Pérez, Diana M. Toro, Thais F. C. Fraga-Silva, Carlos A. Fuzo, Camilla N. S. Oliveira, Lilian C. Rodrigues, Jamille G. M. Argolo, Ingryd Carmona-Garcia, Nicola T. Neto, Camila O. S. Souza, Talita M. Fernandes, Victor A. F. Bastos, Augusto M. Degiovani, Leticia F. Constant, Fátima M. Ostini, Marley R. Feitosa, Rogerio S. Parra, Fernando C. Vilar, Gilberto G. Gaspar, José J. R. da Rocha, Omar Feres, Fabiani G. Frantz, Raquel F. Gerlach, Sandra R. Maruyama, Elisa M. S. Russo, Angelina L. Viana, Ana P. M. Fernandes, Isabel K. F. M. Santos, Vânia L. D. Bonato, Antonio L. Boechat, Adriana Malheiro, Ruxana T. Sadikot, Marcelo Dias-Baruffi, Cristina R. B. Cardoso, Lúcia H. Faccioli, Carlos A. Sorgi, on behalf of the IMUNOCOVID Study Group

Publikováno v: Viruses
Viruses, Vol 13, Iss 2521, p 2521 (2021)
Viruses; Volume 13; Issue 12; Pages: 2521
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is considered an intrinsic amplifier of inflammatory signals, this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d756bb4d7c7341e4e4928b8ed3995b54
http://europepmc.org/articles/PMC8708887