Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Václav Šeda"'
Autor:
Ulrich Jaeger, Marek Borsky, Jan Oppelt, Laura Z. Rassenti, Medhat Shehata, Václav Šeda, Thomas J. Kipps, Gabriela Pavlasova, Jennifer R. Brown, Daniel Filip, Kvetoslava Liskova, Šárka Pospíšilová, Eva Vojackova, Lenka Kostalova, Matthew S. Davids, Marek Mráz, Katerina Cerna, Sonali Sharma, Jiri Mayer, Andrea Janíková, Pedro Faria Zeni, Stacey M. Fernandes, Veronika Šandová, Laura Ondrisova, Michael Doubek, Leos Kren
Publikováno v:
Blood
B-cell receptor (BCR) signaling and T-cell interactions play a pivotal role in chronic lymphocytic leukemia (CLL) pathogenesis and disease aggressiveness. CLL cells can use microRNAs (miRNAs) and their targets to modulate microenvironmental interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a337b68bb9ac88d669bfb33ed5069d
https://doi.org/10.1182/blood.2020005627
https://doi.org/10.1182/blood.2020005627
Autor:
Stanislav Drápela, Miroslav Boudny, Josef Jaroš, Michaela Špunarová, Jan Verner, Prashant Khirsariya, Zuzana Jašková, Kamil Paruch, Yvona Brychtová, Marie Kasparkova, Jana Zemanová, Jiri Mayer, Marek Borsky, Václav Šeda, Jana Černá, Martin Trbušek, Alexandra Oltová, Marek Mráz, Karel Souček
Publikováno v:
Haematologica
Introduction of small-molecule inhibitors of B-cell receptor signaling and BCL2 protein significantly improves therapeutic options in chronic lymphocytic leukemia. However, some patients suffer from adverse effects mandating treatment discontinuation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145501475952e3a04a814fab3a8f9fb2
https://doi.org/10.3324/haematol.2018.203430
https://doi.org/10.3324/haematol.2018.203430
Autor:
Sonali Sharma, Marek Mráz, Veronika Sandova, Yvona Brychtová, Gabriela Mladonická Pavlasová, Matthew S. Davids, Jiri Mayer, Šárka Pospíšilová, Veronika Palusova, Stacey M. Fernandes, Michael Doubek, Anna Panovská, Václav Šeda, Katerina Cerna, Jennifer R. Brown
Publikováno v:
Haematologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f516d41be8767048d6931826db94008
https://pubmed.ncbi.nlm.nih.gov/34196167
https://pubmed.ncbi.nlm.nih.gov/34196167
Autor:
Václav Šeda, Laura Ondrisova, Marek Borsky, Vladimir Benes, Sonali Sharma, Jan Verner, Anna Panovská, Daniel Zicha, Kvetoslava Liskova, Marie Kudlickova Peskova, Yvona Brychtová, Eva Vojackova, Michael Doubek, Jiri Mayer, Jan Krivanek, Gabriela Pavlasova, Katerina Cerna, Marek Mráz, Zhi Tan, Jan Oppelt, Šárka Pospíšilová, Tomáš Loja, Katerina Musilova Litzmanova, Lenka Kostalova, Shuxing Zhang, Leos Kren
Publikováno v:
Blood
Recirculation of chronic lymphocytic leukemia (CLL) cells between the peripheral blood and lymphoid niches plays a critical role in disease pathophysiology, and inhibiting this process is one of the major mechanisms of action for B-cell receptor (BCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c852b1baa5692bf5135b13f0235d6
https://pubmed.ncbi.nlm.nih.gov/33786575
https://pubmed.ncbi.nlm.nih.gov/33786575
Autor:
Marie Jarošová, Heidi Mocikova, Jan Oppelt, Leos Kren, Vít Procházka, Katerina Machova Polakova, Pavel Burda, Olaf Merkel, Katerina Cerna, Robert Pytlik, Ana-Iris Schiefer, Marek Trneny, Lenka Zlamalikova, Martin Trbušek, Ján Deván, Lenka Kruzova, Ingrid Simonitsch-Klupp, Václav Šeda, Sonali Sharma, Zuzana Prouzová, Andrea Janíková, Katerina Musilova, Andrew G. Evans, Gabriela Pavlasova, Clive S. Zent, Jiri Mayer, Kvetoslava Liskova, Andrea Marečková, Christoph Kornauth, Marek Mráz
Publikováno v:
Blood. 132:2389-2400
Follicular lymphoma (FL) is a common indolent B-cell malignancy with a variable clinical course. An unfavorable event in its course is histological transformation to a high-grade lymphoma, typically diffuse large B-cell lymphoma. Recent studies show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e57cf8c8ebb70ea36bff26c8c2b49d6a
https://doi.org/10.1182/blood-2018-06-855502
https://doi.org/10.1182/blood-2018-06-855502
Autor:
Marek Borsky, Jan Oppelt, Michael Doubek, Yvona Brychtová, Jitka Novotná, Jiri Fajkus, Šárka Pospíšilová, Veronika Svobodová, Miloslava Fojtová, Václav Šeda, Katerina Cerna, Marek Mráz, Gabriela Pavlasova, Jiri Mayer
Publikováno v:
Leukemia
The use of the anti-CD20 antibody rituximab has improved the outcome of patients with chronic lymphocytic leukemia (CLL). Rituximab was shown to act via various mechanisms, such as antibody-dependent cell-mediated cytotoxicity (ADCC), complement-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01db0e0b54278eb49fbfef4dc2c169e3
https://doi.org/10.1038/s41375-018-0211-0
https://doi.org/10.1038/s41375-018-0211-0
Autor:
Ulrich Jaeger, Marek Mráz, Václav Šeda, Matthew S. Davids, Daniel Filip, Marek Borsky, Jiri Mayer, Laura Ondrisova, Laura Z. Rassenti, Michael Doubek, Pedro Faria Zeni, Lenka Kostalova, Šárka Pospíšilová, Medhat Shehata, Eva Vojackova, Gabriela Pavlasova, Thomas J. Kipps, Veronika Šandová, Jennifer R. Brown, Sonali Sharma
Publikováno v:
Cancer Research. 81:2368-2368
The synchronous activation of BCR and CD40 signaling via B-T cell interactions is required for proliferation of normal (Luo et al, 2018) and some malignant B cells, especially in chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL). In CLL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f036a62de1e6e4c766abc63b224cc1e
https://doi.org/10.1158/1538-7445.am2021-2368
https://doi.org/10.1158/1538-7445.am2021-2368
Autor:
Matthew S. Davids, Jiri Mayer, Gabriela Pavlasova, Jennifer R. Brown, Martin Trbušek, Marek Mráz, Michael Doubek, Marek Borsky, Thomas J. Kipps, Šárka Pospíšilová, Katerina Cerna, Raffaele A. Calogero, Jitka Osičková, Václav Šeda
Publikováno v:
Blood. 128:1609-1613
Agents targeting B-cell receptor (BCR) signaling-associated kinases such as Bruton tyrosine kinase (BTK) or phosphatidylinositol 3-kinase can induce mobilization of neoplastic B cells from the lymphoid tissues into the blood, which makes them potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423db15c342025b2a064225aff5733f6
https://doi.org/10.1182/blood-2016-04-709519
https://doi.org/10.1182/blood-2016-04-709519
Autor:
Šárka Pospíšilová, Katerina Musilova, Václav Šeda, Martin Trbušek, Jan Oppelt, Yvona Brychtová, Jiri Mayer, Marek Mráz, Katerina Cerna, Vaclav Chochola, Michael Doubek, Lenka Radová, Gabriela Pavlasova, Vladimir Benes, Raffaele A. Calogero, Maddalena Arigoni
Publikováno v:
Leukemia. 33(2)
The variable clinical course in chronic lymphocytic leukaemia (CLL) largely depends on p53 functionality and B-cell receptor (BCR) signalling propensity; however, it is unclear if there is any crosstalk between these pathways. We show that DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e538dcfd76ffb264368b00c662b684
https://pubmed.ncbi.nlm.nih.gov/30111844
https://pubmed.ncbi.nlm.nih.gov/30111844
Autor:
Laura Ondrisova, Vaclav Seda, Eva Hoferkova, Giorgia Chiodin, Krystof Hlavac, Lenka Kostalova, Daniel Filip, Pedro Faria Zeni, Anna Panovska, Karla Plevova, Sarka Pospisilova, Martin Simkovic, Filip Vrbacky, Daniel Lysak, Stacey M. Fernandes, Matthew S. Davids, Alba Maiques-Diaz, Stella Charalampopoulou, Jose I Martin-Subero, Jennifer R Brown, Michael Doubek, Francesco Forconi, Jiri Mayer, Marek Mraz
Publikováno v:
HemaSphere, Vol 7, p e8228434 (2023)
Externí odkaz:
https://doaj.org/article/d170c389beac401f8b76921cc6daacb9