Zobrazeno 1 - 2
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pro vyhledávání: '"Václav Šístek"'
Publikováno v:
Biomedical Chromatography. 27:111-121
We optimized and validated a rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of six metabolites of homocysteine metabolism: homocysteine, methionine, cysteine, S-adenosylmethionine, S-adenos
Autor:
Igor Linhart, Petr Mikeš, Václav Šístek, Antonín Králík, Emil Frantík, Jan Krouželka, Jaroslav Mráz
Publikováno v:
Journal of Applied Toxicology. 33:516-520
Metabolism of benzene, an important environmental and industrial carcinogen, produces three electrophilic intermediates, namely, benzene oxide and 1,2- and 1,4-benzoquinone, capable of reacting with the DNA. Numerous DNA adducts formed by these metab