Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Václav, Martínek"'
Autor:
Tereza Rákosníková, Silvie Kelifová, Hana Štufková, Kateřina Lokvencová, Petra Lišková, Bohdan Kousal, Tomáš Honzík, Hana Hansíková, Václav Martínek, Markéta Tesařová
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Leber hereditary optic neuropathy is a primary mitochondrial disease characterized by acute visual loss due to the degeneration of retinal ganglion cells. In this study, we describe a patient carrying a rare missense heteroplasmic variant in MT-ND1,
Externí odkaz:
https://doaj.org/article/12ee8ca3d0004c67b8c245a36ed355c8
Autor:
Marie Stiborová, František Bárta, Kateřina Levová, Petr Hodek, Heinz H. Schmeiser, Volker M. Arlt, Václav Martínek
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 11, Pp 27561-27575 (2015)
Aristolochic acid I (AAI) is a plant alkaloid causing aristolochic acid nephropathy, Balkan endemic nephropathy and their associated urothelial malignancies. AAI is detoxified by cytochrome P450 (CYP)-mediated O-demethylation to 8-hydroxyaristolochic
Externí odkaz:
https://doaj.org/article/deb96ba69f364149b998d2bdee98daab
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 6, Pp 10271-10295 (2014)
This review summarizes the results found in studies investigating the enzymatic activation of two genotoxic nitro-aromatics, an environmental pollutant and carcinogen 3-nitrobenzanthrone (3-NBA) and a natural plant nephrotoxin and carcinogen aristolo
Externí odkaz:
https://doaj.org/article/680ac9a3155c47fdb22274532159b205
Autor:
Radek Indra, Petr Pompach, Václav Martínek, Paulína Takácsová, Katarína Vavrová, Zbyněk Heger, Vojtěch Adam, Tomáš Eckschlager, Kateřina Kopečková, Volker Manfred Arlt, Marie Stiborová
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3392 (2019)
The metabolism of vandetanib, a tyrosine kinase inhibitor used for treatment of symptomatic/progressive medullary thyroid cancer, was studied using human hepatic microsomes, recombinant cytochromes P450 (CYPs) and flavin-containing monooxygenases (FM
Externí odkaz:
https://doaj.org/article/83936630d3544288aeea09a012d49661
Autor:
Václav Martínek, František Bárta, Volker M. Arlt, Petr Hodek, Kevin Kotalík, Marie Stiborová, Alena Dedı́ková, Šárka Dušková, Jaroslav Mráz
Publikováno v:
Chemical Research in Toxicology. 33:2804-2818
The plant extract aristolochic acid (AA), containing aristolochic acid I (AAI) and II (AAII) as major components, causes aristolochic acid nephropathy and Balkan endemic nephropathy, unique renal d...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4fcfd17751f58285c1aa40c80804a8f
https://doi.org/10.1021/acs.chemrestox.0c00198
https://doi.org/10.1021/acs.chemrestox.0c00198
Autor:
Jan Milichovký, František Bárta, Heinz H. Schmeiser, Volker M. Arlt, Eva Frei, Marie Stiborová, Václav Martínek
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 2, p 213 (2016)
Aristolochic acid I (AAI) is a plant drug found in Aristolochia species that causes aristolochic acid nephropathy, Balkan endemic nephropathy and their associated urothelial malignancies. AAI is activated via nitroreduction producing genotoxic N-hydr
Externí odkaz:
https://doaj.org/article/b3c31dce12f148b8a6b685a352a73799
Autor:
Veronika Fojtikova, Michal Rosůlek, Petr Man, Martin Stranava, Toru Shimizu, Marketa Martinkova, Petr Kolenko, Jan Dohnálek, Tereza Skálová, Václav Martínek, Alzbeta Lengalova, Jan Bláha
Publikováno v:
Journal of Biological Chemistry. 292:20921-20935
The heme-based oxygen sensor histidine kinase AfGcHK is part of a two-component signal transduction system in bacteria. O2 binding to the Fe(II) heme complex of its N-terminal globin domain strongly stimulates autophosphorylation at His183 in its C-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d146df2cfe8df233fe2741d406eb996f
https://doi.org/10.1074/jbc.m117.817023
https://doi.org/10.1074/jbc.m117.817023
Autor:
Jiri Zeman, Tomas Honzik, Marketa Tesarova, Václav Martínek, Jana Sladkova, Daniela Burska, Marie Vanisova, Josef Zamecnik, Lukas Stiburek, Hana Hansikova, Jana Krizova
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1867:166147
The mitochondrial respiratory chain (MRC) complex III (CIII) associates with complexes I and IV (CI and CIV) into supercomplexes. We identified a novel homozygous missense mutation (c.665G>C; p.Gly222Ala) in UQCRC2 coding for structural subunit Core
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a234b800c6de63faa669af2a4b4728
https://doi.org/10.1016/j.bbadis.2021.166147
https://doi.org/10.1016/j.bbadis.2021.166147
Autor:
Jakub Vavra, Marketa Martinkova, Toru Shimizu, Václav Martínek, Veronika Fojtikova-Proskova, Alzbeta Lengalova, Martin Stranava
Publikováno v:
Journal of inorganic biochemistry. 201
Heme-based oxygen sensors allow bacteria to regulate their activity based on local oxygen levels. YddV, a globin-coupled oxygen sensor with diguanylate cyclase activity from Escherichia coli, regulates cyclic-di-GMP synthesis based on oxygen availabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6d75e7b3335275a8055f49f34cd2b9
https://pubmed.ncbi.nlm.nih.gov/31520879
https://pubmed.ncbi.nlm.nih.gov/31520879
Autor:
Petr Man, Marketa Martinkova, Toru Shimizu, Václav Martínek, Martin Stranava, Veronika Fojtikova, Daniel Kavan, Ondřej Vaněk
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:1375-1389
The oxygen sensor histidine kinase AfGcHK from the bacterium Anaeromyxobacter sp. Fw 109-5 forms a two-component signal transduction system together with its cognate response regulator (RR). The binding of oxygen to the heme iron of its N-terminal se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4e568e7e71fff461cdc734a7121b971
https://doi.org/10.1002/prot.25083
https://doi.org/10.1002/prot.25083