Zobrazeno 1 - 10
of 66
pro vyhledávání: '"V, Spacek"'
Autor:
Fereshteh Jahanbani, Rajan D Maynard, Justin Cyril Sing, Shaghayegh Jahanbani, John J Perrino, Damek V Spacek, Ronald W Davis, Michael P Snyder
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272703 (2022)
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex chronic multi-systemic disease characterized by extreme fatigue that is not improved by rest, and worsens after exertion, whether physical or mental. Previous studies have shown
Externí odkaz:
https://doaj.org/article/fa19d63993334ea29d18efe430e2609a
Akademický článek
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Akademický článek
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Autor:
Akshay Sanghi, Stephen Dalton, Maya Kasowski, Michael Kulik, Fabian Grubert, Damek V. Spacek, Mariana Ruiz-Velasco, Qing Liu, Anshul Kundaje, Marlene Rabinovitch, Benjamin Geller, Anil Narasimha, Peyton Greenside, Judith B. Zaugg, Nasa Sinnott-Armstrong, Michael Snyder, Silin Sa, Rohith Srivas
Publikováno v:
Nature
Physical interactions between distal regulatory elements have a key role in regulating gene expression, but the extent to which these interactions vary between cell types and contribute to cell-type-specific gene expression remains unclear. Here, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7464e87b91325736eb92d4cd8a268a0f
https://doi.org/10.1038/s41586-020-2151-x
https://doi.org/10.1038/s41586-020-2151-x
Publikováno v:
Nature methods
Paired DNA and RNA profiling is increasingly employed in genomics research to uncover molecular mechanisms of disease and to explore personal genotype and phenotype correlations. here, we introduce Simul-seq, a technique for the production of high-qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d5a4fb92a2481b0966e93250e91a8c
https://doi.org/10.1038/nmeth.4028
https://doi.org/10.1038/nmeth.4028
Autor:
Aleksandra Pekowska, Fabian Grubert, Wolfgang Huber, Michael Snyder, Jonathan K. Pritchard, Anshul Kundaje, Carlos Bustamante, Ghia Euskirchen, Judith B. Zaugg, Lars M. Steinmetz, Peyton Greenside, Rohith Srivas, Oana Ursu, Nastaran Heidari, Doug H. Phanstiel, Alicia R. Martin, Damek V. Spacek, Maya Kasowski
Publikováno v:
Cell. 162(5):1051-1065
SummaryDeciphering the impact of genetic variants on gene regulation is fundamental to understanding human disease. Although gene regulation often involves long-range interactions, it is unknown to what extent non-coding genetic variants influence di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca783469a5aab50cfcd943752d79985
Publikováno v:
Nature genetics
Aberrant regulation of gene expression in cancer can promote survival and proliferation of cancer cells. Here we integrate whole-genome sequencing data from The Cancer Genome Atlas (TCGA) for 436 patients from 8 cancer subtypes with ENCODE and other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f97e6f2ee33f23df300247191ab7f90
http://europepmc.org/articles/PMC4485503
http://europepmc.org/articles/PMC4485503
Autor:
Michael Snyder, Michael I. Love, Muhammad S. Shamim, Douglas H. Phanstiel, Ido Machol, Kevin Van Bortle, Michael C. Bassik, Damek V. Spacek, Erez Lieberman Aiden, Gaelen T. Hess
SUMMARYThe three-dimensional arrangement of the human genome comprises a complex network of structural and regulatory chromatin loops important for coordinating changes in transcription during human development. To better understand the mechanisms un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab3ea26693a2acdfc9334c3a048c412
Autor:
Michael I. Love, Damek V. Spacek, Gaelen T. Hess, Douglas H. Phanstiel, Muhammad S. Shamim, Kevin Van Bortle, Erez Lieberman Aiden, Michael C. Bassik, Michael Snyder, Ido Machol
Publikováno v:
Molecular cell. 67(6)
The three-dimensional arrangement of the human genome comprises a complex network of structural and regulatory chromatin loops important for coordinating changes in transcription during human development. To better understand the mechanisms underlyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6445a42eca9a48aa00276fa507d5eb1d
https://pubmed.ncbi.nlm.nih.gov/28890333
https://pubmed.ncbi.nlm.nih.gov/28890333
Akademický článek
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